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E Anders Kolb Selected Research

Rhabdoid Tumor (Rhabdoid Tumors)

7/2010Initial testing of the aurora kinase A inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP).
12/2009Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program.
7/2008Initial testing (stage 1) of sunitinib by the pediatric preclinical testing program.
6/2008Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program.
6/2008Successful outcome with tandem myeloablative chemotherapy and autologous peripheral blood stem cell transplants in a patient with atypical teratoid/rhabdoid tumor of the central nervous system.
5/2008Initial testing of cisplatin by the pediatric preclinical testing program.

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E Anders Kolb Research Topics

Disease

70Neoplasms (Cancer)
11/2015 - 09/2003
25Osteosarcoma (Osteogenic Sarcoma)
01/2016 - 08/2003
23Sarcoma (Soft Tissue Sarcoma)
11/2015 - 09/2007
17Rhabdomyosarcoma
07/2015 - 09/2007
16Neuroblastoma
07/2015 - 03/2008
13Leukemia
02/2015 - 12/2003
12Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2015 - 01/2008
9Glioblastoma (Glioblastoma Multiforme)
02/2014 - 03/2008
7Wilms Tumor (Wilm's Tumor)
11/2014 - 05/2008
6Rhabdoid Tumor (Rhabdoid Tumors)
07/2010 - 05/2008
4Ewing's Sarcoma (Sarcoma, Ewing)
10/2013 - 09/2007
3Medulloblastoma
04/2013 - 03/2008
3Alveolar Rhabdomyosarcoma
04/2013 - 07/2008
2Breast Neoplasms (Breast Cancer)
01/2016 - 10/2009
2Neoplasm Metastasis (Metastasis)
05/2009 - 04/2004
2Philadelphia Chromosome
06/2008 - 12/2003
2BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
06/2008 - 12/2003
1Melanoma (Melanoma, Malignant)
01/2016
1Acute Promyelocytic Leukemia
12/2015
1Down Syndrome (Down's Syndrome)
12/2015
1Weight Loss (Weight Reduction)
07/2015
1Rare Diseases (Rare Disease)
01/2015
1Liver Neoplasms (Liver Cancer)
01/2015
1Sudden Infant Death (SID)
11/2014
1Infection
01/2014
1Dyskeratosis Congenita (X-Linked Dyskeratosis Congenita)
08/2013
1Myeloid Leukemia (Leukemia, Myelocytic)
10/2012
1Hyperalgesia
10/2011
1Inflammation
10/2011

Drug/Important Bio-Agent (IBA)

36N- propyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (PPTP)IBA
11/2015 - 12/2007
5Sirolimus (Rapamycin)FDA Link
05/2012 - 04/2008
4Vincristine (Oncovin)FDA LinkGeneric
11/2015 - 12/2007
4Phosphotransferases (Kinase)IBA
05/2013 - 06/2008
3Messenger RNA (mRNA)IBA
01/2016 - 05/2007
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
05/2015 - 12/2007
3temozolomide (Temodar)FDA LinkGeneric
02/2015 - 05/2013
3Cisplatin (Platino)FDA LinkGeneric
04/2012 - 05/2008
3CytotoxinsIBA
04/2012 - 01/2010
2glembatumumab vedotinIBA
01/2016 - 10/2014
2TaxoidsIBA
11/2015 - 07/2015
2Antimitotic AgentsIBA
07/2015 - 08/2013
2Histone Deacetylase InhibitorsIBA
01/2015 - 09/2009
2vorinostat (suberoylanilide hydroxamic acid)FDA Link
01/2015 - 09/2009
2Insulin (Novolin)FDA Link
01/2014 - 07/2009
2Topotecan (Hycamtin)FDA LinkGeneric
11/2013 - 05/2010
2IGF Type 1 Receptor (IGF 1 Receptor)IBA
05/2012 - 07/2010
24- ((4- Fluoro- 2- methyl- 1H- indol- 5- yl)oxy)- 6- methoxy- 7- (3- (pyrrolidin- 1- yl)propoxy)quinazoline (AZD2171)IBA
04/2012 - 03/2008
2MLN 8237IBA
11/2011 - 07/2010
2Immunoglobulin G (IgG)IBA
07/2010 - 07/2010
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
10/2009 - 05/2009
2dasatinib (BMS 354825)FDA Link
05/2009 - 06/2008
2imatinib (Gleevec)FDA Link
06/2008 - 12/2003
1Glycoproteins (Glycoprotein)IBA
01/2016
1AnthracyclinesIBA
12/2015
1Cytarabine (Cytosar-U)FDA LinkGeneric
12/2015
1Tretinoin (Retinoic Acid)FDA LinkGeneric
12/2015
1ArsenicIBA
12/2015
14- acetoxy- 13- ((3- ((tert- butoxycarbonyl)amino)- 2- hydroxy- 3- phenylpropanoyl)oxy)- 1- hydroxy- 7,10- dimethoxy- 9- oxo- 5,20- epoxytax- 11- en- 2- yl benzoateFDA Link
11/2015
1docetaxel (Taxotere)FDA Link
11/2015
1130-nm albumin-bound paclitaxelIBA
07/2015
1albumin-bound paclitaxelFDA Link
07/2015
1MicroRNAs (MicroRNA)IBA
01/2015
1Annexin A2 (Annexin II)IBA
01/2015
1irinotecan (Camptosar)FDA LinkGeneric
01/2015
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
01/2015
1Biological Markers (Surrogate Marker)IBA
01/2015
1AZD1480IBA
11/2014
1Angiogenesis InhibitorsIBA
11/2014
1Janus KinasesIBA
11/2014
1Adenosine Triphosphate (ATP)IBA
11/2014
1RNA (Ribonucleic Acid)IBA
10/2014
12- (5,7- difluoro- 1,2,3,4- tetrahydronaphthalen- 3- ylamino)- N- (1- (2- methyl- 1- (neopentylamino)propan- 2- yl)- 1H- imidazol- 4- yl)pentanamideIBA
08/2014
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
02/2014
1polo-like kinase 1IBA
01/2014
1BI 6727IBA
01/2014
12- (3- amino- 2- hydroxypropyl)hexacosahydro- 3- methoxy- 26- methyl- 20,27- bis(methylene)11,15- 18,21- 24,28- triepoxy- 7,9- ethano- 12,15- methano- 9H,15H- furo(3,2- i)furo(2',3'- 5,6)pyrano(4,3- b)(1,4)dioxacyclopentacosin- 5- (4H)- oneIBA
08/2013
1DNA (Deoxyribonucleic Acid)IBA
05/2013
1SGI 1776IBA
10/2012
1MK 2206IBA
09/2012
1((1S,2S,4R)- 4- (4- ((1S)- 2,3- dihydro- 1H- inden- 1- ylamino)- 7H- pyrrolo(2,3- d)pyrimidin- 7- yl)- 2- hydroxycyclopentyl)methyl sulphamateIBA
08/2012
1(2,4- dihydroxy- 5- isopropylphenyl)- (5- (4- methylpiperazin- 1- ylmethyl)- 1,3- dihydroisoindol- 2- yl)methanoneIBA
07/2012
1KinesinIBA
06/2012
1Somatomedin Receptors (Somatomedin Receptor)IBA
05/2012
12,2- dimethyl- N- (6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- N'- (2,2,3,3,3- pentafluoropropyl)malonamideIBA
05/2012
1AntibodiesIBA
05/2012
1(5- (2,4- bis((3S)- 3- methylmorpholin- 4- yl)pyrido(2,3- d)pyrimidin- 7- yl)- 2- methoxyphenyl)methanolIBA
02/2012
1aurora kinase (aurora A kinase)IBA
11/2011
1lenalidomide (CC 5013)FDA Link
10/2011
1PR-104AIBA
09/2011
1PR-104IBA
09/2011
1OxidoreductasesIBA
09/2011

Therapy/Procedure

60Heterologous Transplantation (Xenotransplantation)
11/2015 - 09/2007
7Drug Therapy (Chemotherapy)
01/2015 - 09/2003
2Oncolytic Virotherapy
01/2014 - 02/2012
2Withholding Treatment
07/2008 - 06/2008
1Therapeutics
01/2015
1Cell Transplantation
08/2013
1Transplantation (Transplant Recipients)
08/2013
1Homologous Transplantation (Allograft)
08/2013
1Radiotherapy
05/2013