Shigeru Kohno Selected Research

Infection

01/2008	Mycobacterium intracellulare Pulmonary Infection which Co-existed and Mimicked Lung Cancer.
06/2007	Effects of respiratory syncytial virus infection on dendritic cells and cysteinyl leukotrienes in lung tissues of a murine model of asthma.
01/2006	In vivo efficacies and pharmacokinetics of DX-619, a novel des-fluoro(6) quinolone, against Streptococcus pneumoniae in a mouse lung infection model.
11/2005	Naturally occurring parainfluenza virus 3 infection in adults induces mild exacerbation of asthma associated with increased sputum concentrations of cysteinyl leukotrienes.
08/2005	Impact of Helicobacter pylori infection on gastric and plasma ghrelin dynamics in humans.
03/2005	Sofalcone, a mucoprotective agent, increases the cure rate of Helicobacter pylori infection when combined with rabeprazole, amoxicillin and clarithromycin.
03/2005	Impact of Helicobacter pylori infection on ghrelin and various neuroendocrine hormones in plasma.
02/2005	Enhanced production of leptin in gastric fundic mucosa with Helicobacter pylori infection.
01/2005	[Case reports of the treatment with tobramycin solution for inhalation in severe bronchiectasis patients continuous infection of Pseudomonas aeruginosa]
10/2004	Elevated concentrations of alpha-defensins in gastric juice of patients with Helicobacter pylori infection.
06/2004	Mucosal concentrations of proinflammatory cytokines and chemokines at gastric cardia: implication of Helicobacter pylori infection and gastroesophageal reflux.
05/2004	[A case of invasive group A Streptococcus infection which was successfully treated with linezolid]
12/2003	Effects of DQ-113, a new quinolone, against methicillin- and vancomycin-resistant Staphylococcus aureus-caused hematogenous pulmonary infections in mice.
08/2003	[Successful treatment with linezolid in two cases of methicillin-resistant Staphylococcus aureus infections in the orthopedic field]
06/2003	Role of elastase in a mouse model of chronic respiratory Pseudomonas aeruginosa infection that mimics diffuse panbronchiolitis.
10/2002	Five minute endoscopic urea breath test with 25 mg of (13)C-urea in the management of Helicobacter pylori infection.
10/2002	Efficacy of linezolid against methicillin-resistant or vancomycin-insensitive Staphylococcus aureus in a model of hematogenous pulmonary infection.

Articles by Research Topic

Disease

17	Infection 01/2008 - 10/2002
14	Urinary Tract Infections (Urinary Tract Infection) 08/2006 - 08/2002
13	Pneumonia (Pneumonitis) 06/2008 - 07/2002
11	Small Cell Carcinoma 06/2008 - 03/2003
10	Asthma (Bronchial Asthma) 06/2007 - 01/2003
9	Respiratory Tract Infections (Respiratory Tract Infection) 07/2008 - 05/2002
5	Fibrosis (Cirrhosis) 09/2008 - 01/2003
5	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2008 - 05/2004
5	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 08/2007 - 03/2002
5	IGA Glomerulonephritis (IGA Nephropathy) 01/2007 - 12/2004
5	Communicable Diseases (Infectious Diseases) 10/2006 - 10/2002
4	Gastroesophageal Reflux (GERD) 03/2008 - 04/2004
4	Lung Neoplasms (Lung Cancer) 01/2008 - 01/2002
3	Stomach Neoplasms (Stomach Cancer) 03/2006 - 06/2002
2	Glomerulonephritis 07/2008 - 04/2002
2	Bronchopneumonia 06/2008 - 09/2006
2	Cryptococcosis 05/2008 - 09/2005
2	Dermatomyositis (Dermatopolymyositis) 01/2008 - 05/2004
2	Autoimmune Hepatitis 01/2008 - 08/2007
2	Peptic Esophagitis (Reflux Esophagitis) 03/2007 - 03/2003
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 02/2007 - 01/2006
2	Tropical Spastic Paraparesis (Tropical Spastic Paraplegia) 01/2007 - 02/2005
2	Pulmonary Sarcoidosis 11/2006 - 01/2002
2	Syndrome 09/2006 - 01/2005
2	Membranous Glomerulonephritis (Membranous Nephropathy) 08/2006 - 02/2004
2	Neoplasms (Cancer) 09/2005 - 07/2004
2	Oral Candidiasis (Thrush) 09/2005 - 06/2003
2	Breast Neoplasms (Breast Cancer) 02/2005 - 01/2004
1	Anemia 09/2008
1	Colitis 07/2008
1	Coronary Artery Disease (Coronary Atherosclerosis) 07/2008
1	Obstructive Sleep Apnea 06/2008
1	Cross Infection (Nosocomial Infection) 06/2008

Drug/Important Bio-Agent (IBA)

15	Anti-Infective Agents (Microbicides)IBA 08/2006 - 08/2002
7	Anti-Bacterial Agents (Antibiotics)IBA 01/2008 - 10/2002
7	GhrelinIBA 05/2007 - 09/2004
6	AntibodiesIBA 01/2008 - 03/2002
6	gefitinib (Iressa)FDA Link 11/2006 - 02/2005
4	Vancomycin FDA LinkGeneric 06/2008 - 10/2002
4	irinotecan (Camptosar)FDA LinkGeneric 06/2008 - 12/2004
4	Epidermal Growth Factor Receptor (EGF Receptor)IBA 04/2008 - 02/2005
4	LeukotrienesIBA 06/2007 - 08/2003
3	Interleukin-8 (Interleukin 8)IBA 03/2008 - 04/2004
3	Chemokine CCL5IBA 03/2008 - 08/2003
3	telithromycin (Ketek)FDA Link 01/2007 - 04/2003
3	Prednisolone (Predate)FDA LinkGeneric 01/2007 - 07/2002
3	Heat-Shock Proteins (Heat-Shock Protein)IBA 03/2006 - 01/2003
3	Immunoglobulin A (IgA)IBA 03/2006 - 05/2003
3	Penicillins (Penicillin)FDA Link 04/2005 - 06/2004
3	Histone Deacetylases (Histone Deacetylase)IBA 11/2004 - 02/2002
3	linezolid (Zyvox)FDA Link 05/2004 - 10/2002
3	NF-kappa B (NF-kB)IBA 04/2004 - 01/2003
2	AntigensIBA 07/2008 - 09/2005
2	Simvastatin (Zocor)FDA LinkGeneric 07/2008 - 10/2005
2	vinorelbine (Navelbine)FDA LinkGeneric 06/2008 - 01/2008
2	beta-Lactamases (beta-Lactamase)IBA 06/2008 - 01/2007
2	SPA S 843IBA 05/2008 - 05/2008
2	HSP47 Heat-Shock Proteins (Heat Shock Protein 47)IBA 01/2008 - 01/2003
2	ONO 5046 (sivelestat)IBA 01/2008 - 03/2007
2	Cisplatin (Platino)FDA LinkGeneric 01/2008 - 08/2007
2	Carbon MonoxideIBA 01/2008 - 01/2007
2	Erythromycin (Erycette)FDA LinkGeneric 01/2008 - 06/2004
2	QuinolonesIBA 10/2007 - 04/2003
2	Leukocyte Elastase (Neutrophil Elastase)IBA 07/2007 - 03/2007
2	Fluorouracil (Carac)FDA LinkGeneric 04/2007 - 06/2002
2	OsteopontinIBA 02/2007 - 05/2003
2	Losartan (Cozaar)FDA Link 01/2007 - 12/2004
2	Ampicillin (Omnipen)FDA LinkGeneric 01/2007 - 01/2006
2	Interferon-gamma (Interferon, gamma)IBA 11/2006 - 06/2003
2	Carboplatin (JM8)FDA LinkGeneric 11/2006 - 12/2004
2	DX 619IBA 09/2006 - 01/2006
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2006 - 01/2003
2	bredinin (mizoribine)IBA 08/2006 - 04/2006
2	OxidoreductasesIBA 03/2006 - 05/2003
2	LeptinIBA 12/2005 - 02/2005
2	MucinsIBA 10/2005 - 07/2005
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 09/2005 - 02/2005
2	Clarithromycin (Biaxin)FDA LinkGeneric 03/2005 - 05/2002
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2005 - 12/2004
2	romidepsin (FK228)IBA 11/2004 - 03/2003
2	gatifloxacin (Zymar)FDA Link 06/2004 - 06/2002
2	ChemokinesIBA 06/2004 - 03/2003
2	Cyclosporine (Ciclosporin)FDA LinkGeneric 05/2004 - 09/2003
1	IronIBA 09/2008
1	hepcidinIBA 09/2008
1	Bleomycin (Blenoxane)FDA LinkGeneric 09/2008
1	ErythropoietinIBA 09/2008
1	P-SelectinIBA 07/2008
1	Snake Venoms (Snake Venom)IBA 07/2008
1	atorvastatin (Lipitor)FDA Link 07/2008
1	Interleukin-6 (Interleukin 6)IBA 07/2008
1	oxidized low density lipoproteinIBA 07/2008
1	procalcitoninIBA 06/2008
1	C-Reactive ProteinIBA 06/2008
1	liposomal amphotericin B FDA Link 05/2008
1	micafungin (FK463)FDA Link 05/2008
1	Amphotericin B (Amphotericin)FDA LinkGeneric 05/2008

Therapy/Procedure

2	Ligation 10/2007 - 11/2003
2	Renal Dialysis (Hemodialysis) 02/2005 - 07/2004
1	Continuous Positive Airway Pressure 06/2008