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Kevin M Koch Selected Research

lapatinib (GW572016)

1/2015Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor.
10/2014A phase I pharmacokinetics study of lapatinib and tamoxifen in metastatic breast cancer (EORTC 10053 Lapatam study).
5/2014Phase I dose-escalation study of 5-day intermittent oral lapatinib therapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer.
9/2012Phase II trial of lapatinib in adult and pediatric patients with neurofibromatosis type 2 and progressive vestibular schwannomas.
2/2010Resistance to ErbB2 tyrosine kinase inhibitors in breast cancer is mediated by calcium-dependent activation of RelA.
11/2009A phase I and pharmacokinetic study of oral lapatinib administered once or twice daily in patients with solid malignancies.
9/2009A phase I study of a 2-day lapatinib chemosensitization pulse preceding nanoparticle albumin-bound Paclitaxel for advanced solid malignancies.
3/2009Effects of food on the relative bioavailability of lapatinib in cancer patients.
12/2008Evaluation of lapatinib and topotecan combination therapy: tissue culture, murine xenograft, and phase I clinical trial data.
10/2008A phase I study of lapatinib in combination with carboplatin in women with platinum sensitive recurrent ovarian carcinoma.
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Kevin M Koch Research Topics

Disease

15Neoplasms (Cancer)
01/2015 - 04/2005
9Breast Neoplasms (Breast Cancer)
01/2015 - 08/2005
4Neutropenia
09/2009 - 07/2006
3Anemia
07/2013 - 07/2006
3Lymphopenia (Lymphocytopenia)
07/2013 - 07/2006
3Hypoalbuminemia
07/2013 - 07/2006
2Hyperglycemia
07/2013 - 06/2008
2Headache (Headaches)
07/2013 - 01/2005
2Carcinoma (Carcinomatosis)
10/2008 - 08/2005
1B-Cell Lymphoma (Lymphoma, B Cell)
07/2013
1Fever (Fevers)
07/2013
1Lymphoma (Lymphomas)
07/2013
1Chills
07/2013
1Nausea
07/2013
1Non-Hodgkin Lymphoma (Lymphosarcoma)
07/2013
1Acoustic Neuroma (Acoustic Neurinoma)
09/2012
1Neurofibromatosis 2 (Neurofibromatosis Type II)
09/2012
1Synovitis
09/2011
1Osteolysis
09/2011
1Vomiting
09/2009
1Hyponatremia
07/2006
1Thrombocytopenia (Thrombopenia)
07/2006
1Inflammatory Breast Neoplasms
08/2005
1Exanthema (Rash)
01/2005
1Diarrhea
01/2005

Drug/Important Bio-Agent (IBA)

18lapatinib (GW572016)FDA Link
01/2015 - 01/2005
6Epidermal Growth Factor Receptor (EGF Receptor)IBA
05/2014 - 08/2005
5Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2015 - 04/2008
4Phosphotransferases (Kinase)IBA
02/2010 - 04/2005
3Interleukin-18 (Interleukin 18)IBA
07/2013 - 07/2006
3AntigensIBA
07/2013 - 07/2006
3Tyrosine (L-Tyrosine)FDA Link
02/2010 - 04/2005
2P-GlycoproteinIBA
12/2008 - 04/2008
2trastuzumab (Herceptin)FDA Link
07/2008 - 08/2005
1Epidermal Growth Factor (EGF)IBA
01/2015
1TamoxifenFDA LinkGeneric
10/2014
1rituximab (Mabthera)FDA Link
07/2013
1BilirubinIBA
07/2013
1Small Interfering RNA (siRNA)IBA
02/2010
1CalciumIBA
02/2010
1tyrosine receptor (receptor, tyrosine)IBA
02/2010
1NF-kappa B (NF-kB)IBA
02/2010
1Protein Kinases (Protein Kinase)IBA
01/2010
1Sirolimus (Rapamycin)FDA Link
01/2010
1130-nm albumin-bound paclitaxelIBA
09/2009
1Topotecan (Hycamtin)FDA LinkGeneric
12/2008
1Carboplatin (JM8)FDA LinkGeneric
10/2008
1PlatinumIBA
10/2008
1letrozole (Femara)FDA LinkGeneric
07/2008
1Progesterone Receptors (Progesterone Receptor)IBA
07/2008
1Estrogens (Estrogen)FDA Link
07/2008
1docetaxel (Taxotere)FDA Link
06/2008
1pegfilgrastim (Neulasta)FDA Link
06/2008
1CreatinineIBA
06/2008
1capecitabine (Xeloda)FDA Link
04/2008
1Leucovorin (Folinic Acid)FDA Link
08/2007
1Fluorouracil (Carac)FDA LinkGeneric
08/2007
1oxaliplatin (Eloxatin)FDA LinkGeneric
08/2007
1TransaminasesIBA
07/2006

Therapy/Procedure

2Heterologous Transplantation (Xenotransplantation)
01/2015 - 12/2008
1Arthroplasty
09/2011
1Drug Therapy (Chemotherapy)
09/2009
1Intravenous Infusions
07/2006