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Mikko I Kettunen Selected Research

Pyruvic Acid (Pyruvate)

11/2013Spin echo measurements of the extravasation and tumor cell uptake of hyperpolarized [1-(13) C]lactate and [1-(13) C]pyruvate.
8/2012Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis.
2/2012Hyperpolarized (13)C spectroscopy detects early changes in tumor vasculature and metabolism after VEGF neutralization.
7/2011Kinetic modeling of hyperpolarized 13C label exchange between pyruvate and lactate in tumor cells.
7/2011Detection of tumor glutamate metabolism in vivo using (13)C magnetic resonance spectroscopy and hyperpolarized [1-(13)C]glutamate.
2/2011Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1- 13C]pyruvate and 13C magnetic resonance spectroscopic imaging.
12/2010Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.
4/2010Magnetization transfer measurements of exchange between hyperpolarized [1-13C]pyruvate and [1-13C]lactate in a murine lymphoma.
6/2009A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized (13)C-labeled pyruvate utilization as methods for detecting tumor response to treatment.
11/2007Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

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Mikko I Kettunen Research Topics

Disease

21Neoplasms (Cancer)
10/2015 - 06/2003
10Lymphoma (Lymphomas)
01/2014 - 07/2005
6Glioma (Gliomas)
02/2011 - 06/2003
5Ischemia
04/2005 - 03/2002
3Necrosis
02/2012 - 11/2009
2Colorectal Neoplasms (Colorectal Cancer)
10/2015 - 02/2012
2Hepatocellular Carcinoma (Hepatoma)
07/2011 - 08/2008
2Brain Ischemia (Cerebral Ischemia)
04/2005 - 02/2002
2Alzheimer Disease (Alzheimer's Disease)
07/2002 - 02/2002
1Heart Diseases (Heart Disease)
05/2015
1Lupus Nephritis
08/2012
1Glomerulonephritis
08/2012
1Fanconi Anemia (Fanconi's Anemia)
02/2011
1Body Weight (Weight, Body)
06/2005
1Lipodystrophy
06/2005
1Insulin Resistance
06/2005
1Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
04/2005
1Seizures (Seizure)
09/2004
1Peripheral Vascular Diseases (Peripheral Vascular Disease)
01/2003
1Renal Cell Carcinoma (Grawitz Tumor)
11/2002
1Anoxia (Hypoxia)
04/2002
1Inflammation
02/2002

Drug/Important Bio-Agent (IBA)

10Pyruvic Acid (Pyruvate)IBA
11/2013 - 11/2007
9Lactic AcidFDA LinkGeneric
01/2014 - 11/2007
5Thymidine KinaseIBA
06/2007 - 06/2003
3GD3 ganglioside (GD(3))IBA
01/2014 - 03/2008
3L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
03/2012 - 11/2007
3malic acid (malate)IBA
02/2012 - 11/2009
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
02/2012 - 04/2002
3Ganciclovir (Cytovene)FDA LinkGeneric
04/2004 - 06/2003
2Etoposide (VP 16)FDA LinkGeneric
01/2014 - 11/2009
2Biological Markers (Surrogate Marker)IBA
08/2012 - 02/2012
2GadoliniumIBA
02/2012 - 03/2008
2SuspensionsIBA
08/2011 - 07/2011
2Glutamic Acid (Glutamate)FDA Link
07/2011 - 08/2008
2LipidsIBA
07/2005 - 06/2003
2Amyloid (Amyloid Fibrils)IBA
07/2002 - 02/2002
1Carbonic Anhydrases (Carbonic Anhydrase)IBA
10/2015
1Carbon DioxideIBA
10/2015
1Cocaine (Cocaine HCl)IBA
05/2015
1Aldehyde DehydrogenaseIBA
05/2015
1combretastatinIBA
01/2014
1Glucose (Dextrose)FDA LinkGeneric
01/2014
1DeuteriumIBA
03/2012
1HydrogenIBA
03/2012
1Ascorbic Acid (Vitamin C)FDA LinkGeneric
08/2011
1Dehydroascorbic AcidIBA
08/2011
1Alanine Transaminase (SGPT)IBA
07/2011
1DNA (Deoxyribonucleic Acid)IBA
02/2011
1Succinic Acid (Succinate)IBA
11/2009
1Glutamine (L-Glutamine)FDA Link
08/2008
1GlutaminaseIBA
08/2008
1Contrast MediaIBA
03/2008
1Synaptotagmin IIBA
03/2008
1NAD (NADH)IBA
11/2007
1tranilast (N 5')IBA
06/2007
1ferric oxide (iron oxide)IBA
12/2005
1IronIBA
12/2005
1OvalbuminIBA
12/2005
1ferric ferrocyanide (Prussian blue)FDA Link
12/2005
1PPAR gammaIBA
06/2005
1Insulin (Novolin)FDA Link
06/2005
1Minocycline (Cyclops)FDA LinkGeneric
04/2005
1Neuroprotective AgentsIBA
09/2004
1Perchloric Acid (Perchlorates)IBA
11/2003
1Uracil NucleotidesIBA
11/2003
1AdenosineFDA LinkGeneric
11/2003
1Uridine Diphosphate (UDP)IBA
11/2003
1Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
06/2003
1Fibroblast Growth Factor 4IBA
01/2003
1EndostatinsIBA
11/2002
1ApolipoproteinsIBA
07/2002
1Protein Isoforms (Isoforms)IBA
07/2002
1Apolipoproteins E (ApoE)IBA
07/2002
1Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
04/2002
1OxygenIBA
03/2002
1p38 Mitogen-Activated Protein KinasesIBA
02/2002
1Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
02/2002
1indole-5-carboxamide (SD 282)IBA
02/2002

Therapy/Procedure

2Aftercare (After-Treatment)
01/2014 - 12/2010
2Intravenous Injections
11/2013 - 02/2011
1Heterologous Transplantation (Xenotransplantation)
02/2012
1Radiotherapy
02/2011
1Drug Therapy (Chemotherapy)
11/2007
1Amputation
04/2002
1Lasers (Laser)
02/2002