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C Ronald Kahn Selected Research

Insulin Resistance

07/2008Hepatic insulin resistance directly promotes formation of cholesterol gallstones.
03/2008Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance.
08/2007Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.
04/2007The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.
04/2006Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.
12/2005Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage.
11/2005Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.
07/2004Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse.
06/2004Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms.
08/2003Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones.
06/2003Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance.
05/2003The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance.

Articles by Research Topic

Disease

12Insulin Resistance
07/2008 - 05/2003
4Syndrome
12/2007 - 07/2004
2Obesity
11/2007 - 07/2002
1Gallstones (Gallstone)
07/2008
1Cardiomegaly (Heart Hypertrophy)
12/2007
1Ischemia
04/2006
1Hypoglycemia (Reactive Hypoglycemia)
05/2005
1Lipodystrophy
02/2004
1Tissue Adhesions
09/2003
1Multiple Myeloma
09/2003
1Retinal Neovascularization
06/2003
1Hyperinsulinism (Hyperinsulinemia)
06/2003
1Glucose Intolerance
07/2002

Drug/Important Bio-Agent (IBA)

7Insulin (Novolin)FDA Link
12/2005 - 05/2003
4Insulin ReceptorIBA
04/2006 - 07/2002
2LeptinIBA
02/2004 - 06/2003
1CholesterolIBA
07/2008
1Dual-Specificity PhosphatasesIBA
03/2008
1GTP Phosphohydrolases (GTPases)IBA
12/2007
1B-insulinIBA
12/2007
1Protons (Proton)IBA
11/2007
1Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA
08/2007
1protein kinase C lambdaIBA
08/2007
1Glucose (Dextrose)FDA LinkGeneric
08/2007
1JNK Mitogen-Activated Protein KinasesIBA
04/2007
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
04/2006
1Liver GlycogenIBA
12/2005
1Glucagon-Like Peptide 1 (GLP 1)IBA
12/2005
1Growth Hormone (Somatotropin)IBA
11/2005
1Stearoyl-CoA DesaturaseIBA
05/2005
1Suppressor of Cytokine Signaling ProteinsIBA
07/2004
1Proteins (Proteins, Gene)IBA
06/2004
1Tyrosine (L-Tyrosine)FDA Link
06/2004
11-Phosphatidylinositol 3-Kinase (PI 3 Kinase)IBA
09/2003
1PPAR gammaIBA
08/2003
1ThiazolidinedionesIBA
08/2003
1IGF Type 1 Receptor (IGF 1 Receptor)IBA
06/2003