Takashi Kadowaki Selected Research

Adiponectin

07/2008	Molecular mechanism of moderate insulin resistance in adiponectin-knockout mice.
07/2007	Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2.
03/2007	Reduced adiponectin level is associated with severity of coronary artery disease.
01/2007	Adiponectin and adiponectin receptors in obesity-linked insulin resistance.
12/2006	Higher levels of adiponectin in American than in Japanese men despite obesity.
07/2006	Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.
06/2006	Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome.
03/2006	Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways.
02/2005	Nuclear receptors as targets for drug development: molecular mechanisms for regulation of obesity and insulin resistance by peroxisome proliferator-activated receptor gamma, CREB-binding protein, and adiponectin.
10/2004	A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance.
01/2003	Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis.
07/2002	Disruption of adiponectin causes insulin resistance and neointimal formation.

13	Insulin Resistance 07/2008 - 01/2002
8	Obesity 01/2007 - 01/2002
4	Syndrome 11/2006 - 12/2004
3	Atherosclerosis (Atheroma) 08/2008 - 01/2003
3	Diabetes Mellitus 04/2007 - 10/2002
2	Type 2 Diabetes Mellitus (MODY) 05/2007 - 02/2003
2	Inflammation 12/2005 - 05/2003
2	Prostatic Neoplasms (Prostate Cancer) 11/2005 - 02/2005
2	Hypertension (High Blood Pressure) 08/2005 - 11/2002
2	Ischemia 08/2004 - 06/2003
1	Cardiovascular Diseases (Cardiovascular Disease) 10/2007
1	Neoplasm Metastasis (Metastasis) 07/2007
1	Stomach Neoplasms (Stomach Cancer) 07/2007
1	Coronary Artery Disease (Coronary Atherosclerosis) 03/2007
1	Hyperplasia 01/2007
1	Hypercholesterolemia 09/2006
1	Hyperglycemia 06/2006
1	Proteinuria 01/2006
1	Acute Kidney Failure (Acute Renal Failure) 01/2006
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 06/2005
1	Hepatocellular Carcinoma (Hepatoma) 06/2005
1	Diabetes Complications 06/2005
1	Werner Syndrome (Werner's Syndrome) 10/2004
1	Communicable Diseases (Infectious Diseases) 07/2004
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 05/2003
1	Colitis 09/2002
1	Rheumatoid Arthritis 07/2002
1	Cardiomegaly (Heart Hypertrophy) 03/2002
1	Lipodystrophy 02/2002

12	AdiponectinIBA 07/2008 - 07/2002
9	PPAR gammaIBA 12/2005 - 01/2002
3	CholesterolIBA 10/2007 - 07/2004
3	pioglitazone (Actos)FDA Link 05/2007 - 10/2004
3	Adiponectin ReceptorsIBA 01/2007 - 12/2005
2	Estramustine FDA Link 11/2005 - 02/2005
2	Insulin (Novolin)FDA Link 06/2004 - 02/2002
2	LigandsIBA 09/2002 - 07/2002
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)FDA Link 08/2008
1	Hemoglobins (Hemoglobin)IBA 04/2007
1	GlucokinaseIBA 01/2007
1	Adrenergic Receptors (Adrenergic Receptor)IBA 11/2006
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 09/2006
1	Farnesyl-Diphosphate Farnesyltransferase (Squalene Synthase)IBA 09/2006
1	Acetic Acid (Vinegar)FDA LinkGeneric 06/2006
1	GhrelinIBA 01/2006
1	Lipoproteins (Lipoprotein)IBA 01/2006
1	PPAR alphaIBA 12/2005
1	Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA 11/2005
1	AngiotensinogenIBA 08/2005
1	adducinIBA 08/2005
1	Carbon MonoxideIBA 06/2005
1	EnzymesIBA 06/2005
1	Protein Kinase CIBA 06/2005
1	3 (or 17)-beta-hydroxysteroid dehydrogenaseIBA 02/2005
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 02/2005
1	CREB-Binding ProteinIBA 02/2005
1	CalciumIBA 12/2004
1	imatinib (Gleevec)FDA Link 05/2004
1	NeuropeptidesIBA 05/2004
1	Insulin ReceptorIBA 05/2004
1	AdrenomedullinIBA 06/2003
1	Mitochondrial DNA (mtDNA)IBA 03/2003
1	CoffeeIBA 02/2003
1	Apolipoproteins E (ApoE)IBA 01/2003
1	acetaldehyde dehydrogenase (aldehyde dehydrogenase (NAD(P)+))IBA 11/2002
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 10/2002
1	3-nitrotyrosineIBA 07/2002