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Elizabeth M Jaffee Selected Research

Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)

4/2015Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer.
1/2015PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T-cell infiltration into pancreatic tumors.
1/2015Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival.
11/2014A safety and feasibility study of an allogeneic colon cancer cell vaccine administered with a granulocyte-macrophage colony stimulating factor-producing bystander cell line in patients with metastatic colorectal cancer.
10/2014A feasibility study of cyclophosphamide, trastuzumab, and an allogeneic GM-CSF-secreting breast tumor vaccine for HER2+ metastatic breast cancer.
12/2013Low total lymphocyte count is associated with poor survival in patients with resected pancreatic adenocarcinoma receiving a GM-CSF secreting pancreatic tumor vaccine.
9/2013Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer.
8/2011CD8⁺ Foxp3⁺ tumor infiltrating lymphocytes accumulate in the context of an effective anti-tumor response.
7/2010Cellular vaccine approaches.
1/2010Paclitaxel enhances early dendritic cell maturation and function through TLR4 signaling in mice.
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Elizabeth M Jaffee Research Topics

Disease

60Neoplasms (Cancer)
08/2015 - 01/2003
15Pancreatic Neoplasms (Pancreatic Cancer)
08/2015 - 08/2004
9Breast Neoplasms (Breast Cancer)
04/2015 - 09/2003
9Adenocarcinoma
12/2013 - 01/2007
2Carcinoma (Carcinomatosis)
04/2015 - 04/2012
2Colonic Neoplasms (Colon Cancer)
01/2015 - 11/2014
2Colorectal Neoplasms (Colorectal Cancer)
11/2014 - 01/2007
2Melanoma (Melanoma, Malignant)
07/2013 - 01/2013
2Prostatic Neoplasms (Prostate Cancer)
07/2013 - 01/2005
2Neoplasm Metastasis (Metastasis)
02/2012 - 01/2011
2Esophageal Neoplasms (Esophageal Cancer)
11/2008 - 01/2008
2Renal Cell Carcinoma (Grawitz Tumor)
07/2005 - 02/2005
1Lymphopenia (Lymphocytopenia)
04/2015
1Fatigue
04/2015
1Fever (Fevers)
04/2015
1Infection
04/2015
1Hashimoto Disease (Thyroiditis, Hashimoto)
01/2015
1Inflammation
07/2013
1Tics (Tic)
07/2011
1Barrett Esophagus (Barrett's Esophagus)
01/2008
1Head and Neck Neoplasms (Head and Neck Cancer)
12/2007
1Mesothelioma
01/2007
1Ovarian Neoplasms (Ovarian Cancer)
01/2007
1Hypersensitivity (Allergy)
02/2005
1Kidney Neoplasms (Kidney Cancer)
02/2005

Drug/Important Bio-Agent (IBA)

25AntigensIBA
04/2015 - 07/2003
18Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
04/2015 - 08/2003
16VaccinesIBA
04/2015 - 01/2003
14Cancer VaccinesIBA
01/2015 - 07/2003
7AntibodiesIBA
08/2015 - 01/2011
7Cyclophosphamide (Cytoxan)FDA LinkGeneric
11/2014 - 05/2005
5megakaryocyte potentiating factorIBA
04/2015 - 08/2004
5DNA (Deoxyribonucleic Acid)IBA
04/2015 - 09/2008
4trastuzumab (Herceptin)FDA Link
10/2014 - 08/2003
4Neoplasm Antigens (Tumor Antigens)IBA
07/2010 - 01/2003
3Carbon MonoxideIBA
01/2015 - 01/2010
3ipilimumabIBA
01/2015 - 07/2013
3Monoclonal AntibodiesIBA
06/2012 - 08/2003
2Annexin A2 (Annexin II)IBA
08/2015 - 01/2011
2Biological Markers (Surrogate Marker)IBA
04/2015 - 10/2014
2EpitopesIBA
01/2015 - 12/2007
2Proteins (Proteins, Gene)IBA
04/2014 - 02/2009
2gemcitabineFDA Link
11/2013 - 07/2011
1Semaphorins (Semaphorin)IBA
08/2015
1EnzymesIBA
04/2015
1InterferonsIBA
01/2015
1cytotoxic T-lymphocyte antigen 4IBA
01/2015
1ThyroglobulinFDA Link
01/2015
1SteamIBA
11/2014
1Antigen Receptors (Antigen Receptor)IBA
07/2013
1sipuleucel-T (APC8015)FDA Link
07/2013
1ParaffinIBA
01/2013
1Protein Kinases (Protein Kinase)IBA
09/2012
1triciribineIBA
09/2012
1LuciferasesIBA
04/2012
1T-Cell Antigen Receptors (T-Cell Receptor)IBA
01/2012
1Small Interfering RNA (siRNA)IBA
01/2011
1Tyrosine (L-Tyrosine)FDA Link
01/2011
1CalciumIBA
01/2011
1Carrier Proteins (Binding Protein)IBA
01/2011
1rituximab (Mabthera)FDA Link
10/2010
1cetuximab (Erbitux)FDA Link
10/2010
1Paclitaxel (Taxol)FDA LinkGeneric
01/2010
1Interleukin-12 (IL 12)IBA
01/2010
1Doxorubicin (Adriamycin)FDA LinkGeneric
12/2009
1Genetic Markers (Genetic Marker)IBA
07/2009
1PeptidesIBA
12/2008
1AutoantigensIBA
05/2008
1Angiogenesis InhibitorsIBA
07/2007
1PlasticsIBA
04/2007
1MORAb-009IBA
01/2007
1Phosphatidylinositols (Phosphatidylinositol)IBA
01/2007
1Membrane Proteins (Integral Membrane Proteins)IBA
01/2007
1methyl(arginyl)- lysyl- prolyl- tryptophyl- tert- leucyl- leucineIBA
09/2005
1CytokinesIBA
07/2005
1HLA-A Antigens (HLA-A)IBA
02/2005
1HLA-B Antigens (HLA-B)IBA
02/2005
1HLA-A*0201 antigenIBA
02/2005
1Fatty Acid Synthetase Complex (Fatty Acid Synthase)IBA
01/2005
1HLA-A2 Antigen (HLA A2 Antigen)IBA
08/2004
1Combined VaccinesIBA
01/2004
1HormonesIBA
09/2003
1Indicators and Reagents (Reagents)IBA
07/2003

Therapy/Procedure

20Immunotherapy
01/2015 - 09/2003
8Drug Therapy (Chemotherapy)
11/2014 - 09/2003
4Therapeutics
01/2011 - 06/2005
2Aftercare (After-Treatment)
01/2015 - 01/2015
2Heterologous Transplantation (Xenotransplantation)
04/2012 - 01/2005
1Castration
07/2013
1Intravenous Injections
02/2012
1Biological Therapy
01/2011
1Radiotherapy
10/2010
1Pancreaticoduodenectomy
07/2009
1Esophagostomy
01/2008
1Chemoprevention
01/2005