Yoichiro Iwakura Selected Research

Arthritis (Polyarthritis)

07/2008	Development of Proteoglycan-Induced Arthritis Is Independent of IL-17.
02/2008	Suppressive role of leukocyte cell-derived chemotaxin 2 in mouse anti-type II collagen antibody-induced arthritis.
10/2007	Anti-type II collagen antibody accelerates arthritis via CXCR2-expressing cells in IL-1 receptor antagonist-deficient mice.
02/2007	Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1.
02/2007	A novel DNA vaccine targeting macrophage migration inhibitory factor protects joints from inflammation and destruction in murine models of arthritis.
02/2006	CD28-dependent differentiation into the effector/memory phenotype is essential for induction of arthritis in interleukin-1 receptor antagonist-deficient mice.
12/2005	Arthritis in mice that are deficient in interleukin-1 receptor antagonist is dependent on genetic background.
12/2004	TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice.
03/2004	The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis.
05/2003	IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist.
02/2002	Suppression of autoimmune arthritis in interleukin-1-deficient mice in which T cell activation is impaired due to low levels of CD40 ligand and OX40 expression on T cells.

Articles by Research Topic

Disease

11	Infection 09/2008 - 01/2002
11	Arthritis (Polyarthritis) 07/2008 - 02/2002
5	Inflammation 05/2007 - 08/2004
5	Rheumatoid Arthritis 09/2006 - 08/2002
3	Colitis 04/2008 - 12/2004
2	Pneumococcal Infections 09/2008 - 03/2007
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 06/2008 - 07/2006
2	Atherosclerosis (Atheroma) 11/2007 - 04/2003
2	Hypersensitivity (Allergy) 05/2006 - 04/2003
2	Contact Dermatitis (Eczema, Contact) 02/2005 - 02/2003
2	Neoplasms (Cancer) 03/2003 - 05/2002
1	Bacterial Pneumonia 03/2008
1	T-Cell Leukemia (Leukemia, T Cell) 01/2008
1	Pancreatitis 06/2007
1	Candidiasis (Moniliasis) 05/2006
1	Obesity 04/2006
1	Ischemia 01/2006
1	Aortitis 08/2005
1	Fatty Liver 02/2005
1	Gastritis 09/2004
1	Hepatitis 07/2004
1	Enteritis 03/2004
1	Toxoplasmosis 01/2004
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 03/2003
1	Hypoglycemia (Reactive Hypoglycemia) 11/2002
1	Respiratory Tract Infections (Respiratory Tract Infection) 03/2002
1	Experimental Melanoma 01/2002
1	Neoplasm Metastasis (Metastasis) 01/2002

Drug/Important Bio-Agent (IBA)

16	Interleukin-1 (Interleukin 1)IBA 09/2008 - 08/2002
8	Interleukin-17 (Interleukin 27)IBA 09/2008 - 05/2003
8	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2007 - 06/2002
5	Interferon-gamma (Interferon, gamma)IBA 03/2007 - 01/2002
3	Interleukin-6 (Interleukin 6)IBA 12/2007 - 03/2004
3	Interleukin-1beta (Interleukin 1 beta)IBA 05/2006 - 11/2002
2	Interleukin-23 (Interleukin 23)IBA 04/2008 - 09/2007
2	Collagen Type II (Type II Collagen)IBA 02/2008 - 10/2007
2	CytokinesIBA 01/2008 - 01/2006
2	Interleukin-1alpha (Interleukin 1 alpha)IBA 11/2007 - 11/2002
2	InterleukinsIBA 05/2006 - 05/2002
2	Interleukin-18 (Interleukin 18)IBA 09/2004 - 05/2002
1	Proteoglycans (Proteoglycan)IBA 07/2008
1	interleukin-22 (IL-22)IBA 03/2008
1	ChemokinesIBA 01/2008
1	Cell Adhesion MoleculesIBA 01/2008
1	NF-kappa B (NF-kB)IBA 06/2007
1	Caerulein (Ceruletide)IBA 06/2007
1	DNA (Deoxyribonucleic Acid)IBA 02/2007
1	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA 09/2006
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 09/2006
1	AntigensIBA 05/2006
1	Messenger RNA (mRNA)IBA 01/2006
1	CholesterolIBA 02/2005
1	urushiolIBA 02/2005
1	Transforming Growth Factor beta (TGF-beta)IBA 12/2004
1	AntibodiesIBA 10/2004
1	Secretory Immunoglobulin A (SIgA)IBA 10/2004
1	Fas Ligand Protein (Fas Ligand)IBA 08/2004
1	Concanavalin AIBA 07/2004
1	Cytokine Receptor gp130IBA 03/2004
1	Tyrosine (L-Tyrosine)FDA Link 03/2004
1	Clostridium difficile tcdA proteinIBA 03/2004
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2004
1	Crk-Associated Substrate ProteinIBA 07/2003
1	Apolipoproteins E (ApoE)IBA 04/2003
1	Combined VaccinesIBA 03/2002
1	Polymeric Immunoglobulin Receptors (Polymeric Immunoglobulin Receptor)IBA 03/2002
1	CD40 Ligand (CD40L)IBA 02/2002
1	bu-zhong-yi-qi-tangIBA 01/2002

Therapy/Procedure

1	Kampo Medicine (Kampo) 01/2002