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S Percy Ivy Selected Research

3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine)

4/2014A phase II trial of sequential ribonucleotide reductase inhibition in aggressive myeloproliferative neoplasms.
6/2013A phase I study of prolonged infusion of triapine in combination with fixed dose rate gemcitabine in patients with advanced solid tumors.
11/2012A dose escalation and pharmacodynamic study of triapine and radiation in patients with locally advanced pancreas cancer.
10/2010The maximum tolerated dose and biologic effects of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) in combination with irinotecan for patients with refractory solid tumors.

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S Percy Ivy Research Topics

Disease

37Neoplasms (Cancer)
11/2015 - 11/2003
4Ovarian Neoplasms (Ovarian Cancer)
09/2015 - 10/2014
3Hypertension (High Blood Pressure)
10/2014 - 05/2010
3Fatigue
10/2014 - 06/2008
3Pancreatic Neoplasms (Pancreatic Cancer)
08/2014 - 06/2011
2Glioblastoma (Glioblastoma Multiforme)
10/2015 - 11/2013
2Renal Cell Carcinoma (Grawitz Tumor)
11/2014 - 08/2013
2Prostatic Neoplasms (Prostate Cancer)
10/2014 - 12/2008
2Liver Diseases (Liver Disease)
07/2013 - 02/2008
2Carcinoma (Carcinomatosis)
02/2012 - 04/2009
2Leukemia
11/2011 - 11/2003
2Disease Progression
10/2010 - 03/2007
1Myelodysplastic Syndromes (Myelodysplastic Syndrome)
11/2014
1Chronic Myelomonocytic Leukemia (Leukemia, Chronic Myelomonocytic)
11/2014
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
04/2014
1Alveolar Soft Part Sarcoma
06/2013
1Melanoma (Melanoma, Malignant)
04/2013
1Cardiovascular Diseases (Cardiovascular Disease)
02/2012
1Myocardial Infarction
11/2011
1Adult Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
11/2011
1Disseminated Intravascular Coagulation
11/2011
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell)
05/2011
1Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous)
10/2010
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
08/2010
1Proteinuria
08/2010
1Diarrhea
08/2010
1Hypopigmentation (Hypomelanosis)
07/2010
1Adenocarcinoma
04/2009
1Stomach Neoplasms (Stomach Cancer)
02/2009
1Chest Pain (Chest Pains)
06/2008
1Breast Neoplasms (Breast Cancer)
04/2007
1Vomiting
03/2007
1Hepatoblastoma
03/2007
1Desmoplastic Small Round Cell Tumor
03/2007
1Neuroblastoma
03/2007
1Ewing's Sarcoma (Sarcoma, Ewing)
03/2007
1Osteosarcoma (Osteogenic Sarcoma)
03/2007
1Nausea
03/2007
1Headache (Headaches)
03/2007
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
05/2005

Drug/Important Bio-Agent (IBA)

1117-(allylamino)-17-demethoxygeldanamycin (17AAG)IBA
04/2012 - 05/2005
84- ((4- Fluoro- 2- methyl- 1H- indol- 5- yl)oxy)- 6- methoxy- 7- (3- (pyrrolidin- 1- yl)propoxy)quinazoline (AZD2171)IBA
01/2015 - 08/2010
5gemcitabineFDA Link
08/2014 - 06/2011
5Heat-Shock Proteins (Heat-Shock Protein)IBA
11/2011 - 11/2003
4PlatinumIBA
05/2015 - 02/2013
43-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine)IBA
04/2014 - 10/2010
4oxaliplatin (Eloxatin)FDA LinkGeneric
02/2013 - 02/2009
4Proteins (Proteins, Gene)IBA
02/2012 - 11/2003
3Amyloid Precursor Protein Secretases (beta-Secretase)IBA
05/2015 - 10/2013
32,2- dimethyl- N- (6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- N'- (2,2,3,3,3- pentafluoropropyl)malonamideIBA
05/2015 - 10/2013
3Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
01/2015 - 08/2010
3Biological Markers (Surrogate Marker)IBA
04/2014 - 04/2007
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2013 - 05/2010
3irinotecan (Camptosar)FDA LinkGeneric
10/2010 - 02/2009
2sunitinib (Sutent)FDA Link
11/2014 - 05/2011
2docetaxel (Taxotere)FDA Link
10/2014 - 04/2012
2Ribonucleotide Reductases (Ribonucleotide Reductase)IBA
04/2014 - 06/2013
2pazopanibIBA
07/2013 - 07/2010
2EnzymesIBA
08/2010 - 03/2007
2capecitabine (Xeloda)FDA Link
04/2009 - 02/2009
2imatinib (Gleevec)FDA Link
02/2008 - 02/2008
1Interleukin-8 (Interleukin 8)IBA
01/2015
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
01/2015
1Angiogenesis InhibitorsIBA
11/2014
1dasatinib (BMS 354825)FDA Link
10/2014
1fludarabineIBA
04/2014
1glucuronyl glucosamine glycan sulfate (Vessel)IBA
11/2013
1placenta growth factorIBA
11/2013
1temsirolimusFDA Link
10/2013
1Dacarbazine (DIC)FDA LinkGeneric
04/2013
1Interleukin-2 (IL2)IBA
04/2013
1ipilimumabIBA
04/2013
1Fluorouracil (Carac)FDA LinkGeneric
02/2013
1Leucovorin (Folinic Acid)FDA Link
02/2013
1Dimethyl Sulfoxide (DMSO)FDA LinkGeneric
04/2012
1bortezomib (Velcade)FDA Link
12/2011
117-aminogeldanamycinIBA
11/2011
1Cytarabine (Cytosar-U)FDA LinkGeneric
11/2011
1Checkpoint kinase 1IBA
11/2011
1Cisplatin (Platino)FDA LinkGeneric
06/2011
1vorinostat (suberoylanilide hydroxamic acid)FDA Link
10/2010
1Histone Deacetylase InhibitorsIBA
10/2010
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
07/2010
1CytotoxinsIBA
01/2009
1HormonesIBA
12/2008
1benzoquinone (quinone)IBA
12/2008
1Rifabutin (Ansamycin)FDA Link
12/2008
1Paclitaxel (Taxol)FDA LinkGeneric
06/2008
1CreatinineIBA
02/2008
1BilirubinIBA
02/2008
1Insulin-Like Growth Factor Binding Protein 2IBA
04/2007
1alpha-Fetoproteins (AFP)IBA
03/2007
1motexafin gadoliniumIBA
04/2006
1major vault proteinIBA
05/2005
1P-GlycoproteinIBA
05/2005
1OxygenIBA
05/2004

Therapy/Procedure

4Therapeutics
11/2015 - 03/2007
4Drug Therapy (Chemotherapy)
10/2015 - 04/2013
2Heterologous Transplantation (Xenotransplantation)
12/2008 - 04/2007
1Castration
10/2014