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Hideshi Ishii Selected Research

Histidine (L-Histidine)

7/2009Fragile gene product, Fhit, in oxidative and replicative stress responses.
12/2008Identification of the expression profile of apoptotic esophageal cancer cells by adenoviral-fragile histidine triad treatment.
11/2004Inactivation of the FHIT gene favors bladder cancer development.
4/2004Effect of exogenous E2F-1 on the expression of common chromosome fragile site genes, FHIT and WWOX.
3/2004Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses.
11/2003Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies.
3/2003Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in breast cancer cell lines.
2/2003Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding.
3/2002Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines.

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Hideshi Ishii Research Topics

Disease

70Neoplasms (Cancer)
01/2016 - 03/2002
22Colorectal Neoplasms (Colorectal Cancer)
07/2015 - 07/2004
15Neoplasm Metastasis (Metastasis)
01/2016 - 12/2004
8Stomach Neoplasms (Stomach Cancer)
04/2013 - 01/2006
5Leukemia
01/2015 - 11/2003
5Breast Neoplasms (Breast Cancer)
12/2014 - 03/2003
5Esophageal Neoplasms (Esophageal Cancer)
02/2011 - 10/2004
5Carcinoma (Carcinomatosis)
05/2007 - 03/2002
4Colonic Neoplasms (Colon Cancer)
12/2015 - 12/2008
2Hepatocellular Carcinoma (Hepatoma)
12/2014 - 08/2014
2Inflammation
05/2013 - 03/2006
2Urinary Bladder Neoplasms (Bladder Cancer)
04/2008 - 11/2004
1Gastrointestinal Neoplasms (Gastrointestinal Cancer)
08/2015
1Glioblastoma (Glioblastoma Multiforme)
03/2015
1Hematologic Neoplasms (Hematological Malignancy)
03/2015
1Osteosarcoma (Osteogenic Sarcoma)
12/2014
1Tics (Tic)
12/2014
1Glioma (Gliomas)
12/2014
1Biliary Tract Neoplasms (Biliary Tract Cancer)
05/2013
1Circulating Neoplastic Cells
04/2013
1Adenocarcinoma
01/2013
1Type 2 Diabetes Mellitus (MODY)
09/2012
1Liver Neoplasms (Liver Cancer)
07/2012

Drug/Important Bio-Agent (IBA)

11MicroRNAs (MicroRNA)IBA
12/2015 - 04/2011
11Messenger RNA (mRNA)IBA
12/2012 - 11/2003
9Histidine (L-Histidine)FDA Link
07/2009 - 03/2002
6Proteins (Proteins, Gene)IBA
09/2012 - 12/2006
5Transcription Factors (Transcription Factor)IBA
12/2015 - 10/2011
4Complementary DNA (cDNA)IBA
06/2012 - 11/2004
4fragile histidine triad proteinIBA
05/2007 - 03/2002
4nitrosobenzylmethylamineIBA
03/2005 - 01/2003
3Fluorouracil (Carac)FDA LinkGeneric
12/2015 - 09/2010
3Pyruvate KinaseIBA
08/2015 - 10/2014
3EnzymesIBA
08/2015 - 09/2014
3Epidermal Growth Factor (EGF)IBA
08/2015 - 12/2004
3Small Interfering RNA (siRNA)IBA
07/2015 - 03/2006
3Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA
12/2014 - 03/2014
3Biological Markers (Surrogate Marker)IBA
01/2014 - 12/2010
3tebufenozide (Mimic)IBA
11/2012 - 10/2008
3RNA (Ribonucleic Acid)IBA
06/2012 - 10/2004
2CytokinesIBA
12/2015 - 05/2013
2Proteasome Endopeptidase Complex (Proteasome)IBA
12/2014 - 01/2006
2AntibodiesIBA
09/2014 - 01/2014
2tumor-associated antigen GA733IBA
04/2014 - 04/2013
2Transforming Growth Factor beta (TGF-beta)IBA
05/2013 - 12/2004
2Aldehyde DehydrogenaseIBA
04/2013 - 04/2013
2Cadherins (E-Cadherin)IBA
07/2012 - 09/2010
2RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
02/2011 - 10/2008
2teleocalcinIBA
01/2011 - 10/2010
2Matrix MetalloproteinasesIBA
12/2010 - 12/2008
2AntigensIBA
02/2010 - 07/2009
2Caspase 3 (Caspase-3)IBA
07/2009 - 10/2004
2Mitomycin (Mitomycin-C)FDA LinkGeneric
12/2008 - 05/2007
2CamptothecinIBA
12/2008 - 05/2007
2Matrix Metalloproteinase 14 (MT1-MMP)IBA
12/2008 - 10/2008
2A-Form DNA (A-DNA)IBA
01/2007 - 11/2003
2Epidermal Growth Factor Receptor (EGF Receptor)IBA
01/2006 - 12/2004
2Histone Deacetylases (Histone Deacetylase)IBA
01/2006 - 05/2005
2Phosphotransferases (Kinase)IBA
01/2006 - 03/2005
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2006 - 12/2004
2romidepsin (FK228)FDA Link
01/2006 - 05/2005
2ZincIBA
10/2004 - 01/2003
1histone methyltransferaseIBA
01/2016
1InterleukinsIBA
12/2015
1Interleukin-17 (Interleukin 27)IBA
12/2015
1CarbonIBA
11/2015
1gemcitabineFDA Link
09/2015
1Polypyrimidine Tract-Binding ProteinIBA
07/2015
1UbiquitinIBA
03/2015
1Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA
03/2015
1RibonucleotidesIBA
01/2015
1phorbolIBA
01/2015
1ATP dependent 26S protease (26S proteasome)IBA
12/2014
1HexokinaseIBA
09/2014
1Pyruvic Acid (Pyruvate)IBA
09/2014
1InterferonsIBA
08/2014
1Fluorescein (Funduscein)FDA LinkGeneric
03/2014
1Paclitaxel (Taxol)FDA LinkGeneric
02/2014
1TaxoidsIBA
02/2014
1CD147 Antigens (Basigin)IBA
01/2014
1Butyrates (Butyrate)IBA
08/2013
1SodiumIBA
08/2013
1Interleukin-6 (Interleukin 6)IBA
05/2013
1Cyclin-Dependent Kinase Inhibitor p16IBA
04/2013
1GTP Phosphohydrolases (GTPases)IBA
01/2013
1rho GTPase-activating proteinIBA
01/2013
1stage-specific embryonic antigen-3 (GL-X)IBA
01/2013
1Alprostadil (Muse)FDA LinkGeneric
01/2013
1Stage-Specific Embryonic AntigensIBA
01/2013
1tensins (tensin)IBA
12/2012
1VitaminsIBA
09/2012
1AcidsIBA
09/2012
1Reactive Oxygen Species (Oxygen Radicals)IBA
07/2012

Therapy/Procedure

8Drug Therapy (Chemotherapy)
03/2015 - 11/2010
4Lasers (Laser)
06/2012 - 05/2007
3Radiotherapy
11/2015 - 12/2010
2Therapeutics
12/2014 - 04/2011
2Heterologous Transplantation (Xenotransplantation)
09/2010 - 11/2004
1Bone Marrow Transplantation (Transplantation, Bone Marrow)
02/2014
1Hematopoietic Stem Cell Transplantation
02/2014