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Kay Huebner Selected Research

Histidine (L-Histidine)

10/2014FHIT suppresses epithelial-mesenchymal transition (EMT) and metastasis in lung cancer through modulation of microRNAs.
7/2009Fragile gene product, Fhit, in oxidative and replicative stress responses.
8/2006Protein expression profiling identifies cyclophilin A as a molecular target in Fhit-mediated tumor suppression.
10/2005Fhit and CHK1 have opposing effects on homologous recombination repair.
2/2005Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer.
2/2005Involvement of the Fhit gene in the ionizing radiation-activated ATR/CHK1 pathway.
3/2004Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses.
11/2003Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies.
2/2003Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding.
7/2002The fragile histidine triad/common chromosome fragile site 3B locus and repair-deficient cancers.

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Kay Huebner Research Topics

Disease

55Neoplasms (Cancer)
05/2015 - 07/2002
13Breast Neoplasms (Breast Cancer)
05/2014 - 02/2005
9Lung Neoplasms (Lung Cancer)
10/2014 - 02/2003
6Neoplasm Metastasis (Metastasis)
10/2014 - 04/2004
6Esophageal Neoplasms (Esophageal Cancer)
09/2012 - 07/2003
4Genomic Instability
02/2015 - 01/2012
4Carcinoma (Carcinomatosis)
02/2012 - 07/2005
4Infection
07/2008 - 10/2005
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
09/2012 - 10/2004
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
05/2010 - 02/2003
2Leukemia
05/2010 - 11/2003
2Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
05/2010 - 06/2006
2Prostatic Neoplasms (Prostate Cancer)
09/2007 - 07/2006
1Inflammation
09/2012
1Noninfiltrating Intraductal Carcinoma (DCIS)
02/2012
1Ductal Carcinoma
02/2012
1Mouth Neoplasms (Oral Cancer)
04/2011
1Salivary Gland Neoplasms (Salivary Gland Cancer)
03/2010
1Stomach Neoplasms (Stomach Cancer)
01/2009
1Hematologic Neoplasms (Hematological Malignancy)
06/2006
1Adenoma (Adenomas)
08/2005
1Body Weight (Weight, Body)
08/2005

Drug/Important Bio-Agent (IBA)

14DNA (Deoxyribonucleic Acid)IBA
02/2015 - 02/2003
13fragile histidine triad proteinIBA
02/2015 - 07/2002
12Proteins (Proteins, Gene)IBA
09/2011 - 07/2002
10Histidine (L-Histidine)FDA Link
10/2014 - 07/2002
8MicroRNAs (MicroRNA)IBA
10/2014 - 10/2007
6ZincIBA
09/2012 - 01/2003
6nitrosobenzylmethylamineIBA
03/2011 - 01/2003
5Messenger RNA (mRNA)IBA
01/2014 - 11/2003
5Caspase 3 (Caspase-3)IBA
07/2009 - 10/2004
4Staphylococcal Protein A (A, Protein)IBA
03/2015 - 09/2006
3Biological Markers (Surrogate Marker)IBA
05/2014 - 02/2005
3Cyclin D1IBA
04/2011 - 07/2003
2RNA (Ribonucleic Acid)IBA
05/2015 - 10/2004
2EnzymesIBA
02/2015 - 10/2007
2VimentinIBA
10/2014 - 07/2012
2Histones (Histone)IBA
05/2014 - 11/2003
2Androgen Receptors (Androgen Receptor)IBA
01/2014 - 09/2007
2Reactive Oxygen Species (Oxygen Radicals)IBA
01/2014 - 05/2008
2Cadherins (E-Cadherin)IBA
07/2012 - 02/2012
2Phosphotransferases (Kinase)IBA
02/2012 - 10/2011
2Estrogens (Estrogen)FDA Link
02/2009 - 04/2004
2Progesterone Receptors (Progesterone Receptor)IBA
02/2009 - 10/2007
2Ferredoxins (Ferredoxin)IBA
01/2009 - 05/2008
2OxidoreductasesIBA
01/2009 - 05/2008
2Mitomycin (Mitomycin-C)FDA LinkGeneric
12/2008 - 05/2007
2CamptothecinIBA
12/2008 - 05/2007
2Caspase 8 (Caspase-8)IBA
07/2008 - 06/2006
2trichostatin A (A 300)IBA
01/2007 - 07/2006
2Histone Deacetylase InhibitorsIBA
01/2007 - 07/2006
2decitabine (5-aza-2'-deoxycytidine)FDA Link
01/2007 - 07/2006
2A-Form DNA (A-DNA)IBA
07/2006 - 11/2003
2CarcinogensIBA
07/2005 - 05/2004
1betaglycan (TGFBR3)IBA
05/2015
1Cytidine DeaminaseIBA
02/2015
1thymidine kinase 1IBA
02/2015
1Fibronectins (Fibronectin)IBA
10/2014
1Threonine (L-Threonine)FDA Link
05/2014
1Protein Isoforms (Isoforms)IBA
02/2012
1First StepIBA
01/2012
1gemcitabineFDA Link
10/2011
1Phenobarbital (Luminal)FDA Link
10/2011
12- ((R)- 2- methylpyrrolidin- 2- yl)- 1H- benzimidazole- 4- carboxamideIBA
10/2011
14-iodo-3-nitrobenzamideIBA
10/2011
1Carboplatin (JM8)FDA LinkGeneric
10/2011
1PF 00477736IBA
10/2011
1Checkpoint kinase 1IBA
10/2011
1Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
10/2011
1Biological Tumor Markers (Tumor Markers)IBA
04/2011
1ChromatinIBA
03/2010
1NitrogenIBA
09/2009
1amidaseIBA
09/2009
1AsparagineIBA
09/2009
1Glutamine (L-Glutamine)FDA Link
09/2009
1omega-amidaseIBA
09/2009
1SulfurIBA
09/2009
1Epidermal Growth Factor Receptor (EGF Receptor)IBA
02/2009
1Transcription Factors (Transcription Factor)IBA
02/2009
1Tyrosine (L-Tyrosine)FDA Link
01/2009
1Heat-Shock Proteins (Heat-Shock Protein)IBA
01/2009
1Arginine (L-Arginine)FDA Link
07/2008
1TamoxifenFDA LinkGeneric
10/2007
1Estrogen Receptor alphaIBA
10/2007
1MethyltransferasesIBA
10/2007
1Prostate-Specific Antigen (Semenogelase)IBA
09/2007
1iodoHis(3)- neurokinin A (INKA)IBA
01/2007
1Cyclin-Dependent Kinase Inhibitor p16IBA
01/2007
1Complementary DNA (cDNA)IBA
01/2007
1Cyclophilin AIBA
08/2006
1Phenylalanine (L-Phenylalanine)FDA Link
08/2006
1Caspase 2IBA
06/2006
1HormonesIBA
01/2006
1ponasterone AIBA
10/2005
1Keratin-14 (Keratin 14)IBA
09/2005
1MetallothioneinIBA
09/2005

Therapy/Procedure

4Heterologous Transplantation (Xenotransplantation)
01/2007 - 10/2005
1Adjuvant Radiotherapy
03/2014
1Therapeutics
01/2014
1Chemoprevention
04/2011