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Gabriel N Hortobagyi Selected Research

Fluorouracil (Carac)

3/2012	Phase III trial evaluating weekly paclitaxel versus docetaxel in combination with capecitabine in operable breast cancer.
8/2011	Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine deaminase-uracil phosphoribosyltransferase.
1/2011	Phase III randomized trial of dose intensive neoadjuvant chemotherapy with or without G-CSF in locally advanced breast cancer: long-term results.
11/2010	Evaluation of a 30-gene paclitaxel, fluorouracil, doxorubicin, and cyclophosphamide chemotherapy response predictor in a multicenter randomized trial in breast cancer.
6/2010	Clinical evaluation of chemotherapy response predictors developed from breast cancer cell lines.
5/2010	A phase 2 study of a fixed combination of uracil and ftorafur and leucovorin given orally in a twice-daily regimen to treat patients with recurrent metastatic breast cancer.
3/2010	A phase 2 study of a fixed combination of uracil and ftorafur (UFT) and leucovorin given orally in a 3-times-daily regimen to treat patients with recurrent metastatic breast cancer.
1/2010	Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial.
6/2008	Limits of observational data in determining outcomes from cancer therapy.
9/2007	Efficacy and safety of neoadjuvant trastuzumab combined with paclitaxel and epirubicin: a retrospective review of the M. D. Anderson experience.

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Gabriel N Hortobagyi Research Topics

Disease

159	Breast Neoplasms (Breast Cancer) 01/2013 - 01/2002
105	Neoplasms (Cancer) 01/2013 - 01/2002
23	Neoplasm Metastasis (Metastasis) 08/2012 - 06/2002
14	Carcinoma (Carcinomatosis) 06/2007 - 05/2002
10	Disease Progression 09/2012 - 04/2002
5	Residual Neoplasm 02/2012 - 04/2004
4	Heart Failure 08/2011 - 11/2002
4	Inflammatory Breast Neoplasms 02/2011 - 02/2004
3	Neutropenia 01/2011 - 01/2003
3	Pancreatic Neoplasms (Pancreatic Cancer) 01/2011 - 10/2002
3	Circulating Neoplastic Cells 05/2010 - 04/2009
2	Obesity 10/2012 - 09/2008
2	Fatigue 02/2012 - 02/2004
2	Pneumonia (Pneumonitis) 02/2012 - 11/2004
2	Noninfiltrating Intraductal Carcinoma (DCIS) 02/2012 - 09/2011
2	Lymphatic Diseases (Lymphadenopathy) 09/2011 - 04/2011
2	Infection 01/2011 - 10/2002
2	Ductal Carcinoma 12/2006 - 01/2005
2	Lobular Carcinoma 12/2006 - 01/2005
1	Peripheral Nervous System Diseases (PNS Diseases) 11/2012

Drug/Important Bio-Agent (IBA)

30	Estrogens (Estrogen)FDA Link 01/2013 - 10/2002
29	HormonesIBA 01/2013 - 10/2002
24	Cyclophosphamide (Cytoxan)FDA LinkGeneric 03/2012 - 10/2002
23	Epidermal Growth Factor Receptor (EGF Receptor)IBA 01/2013 - 10/2002
23	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2011 - 04/2002
22	Paclitaxel (Taxol)FDA LinkGeneric 03/2012 - 05/2002
21	Fluorouracil (Carac)FDA LinkGeneric 03/2012 - 05/2002
19	taxaneIBA 06/2012 - 06/2002
19	trastuzumab (Herceptin)FDA Link 02/2012 - 04/2002
12	Progesterone Receptors (Progesterone Receptor)IBA 01/2013 - 10/2002
12	TaxoidsIBA 12/2011 - 05/2002
11	AnthracyclinesIBA 06/2012 - 09/2003
11	docetaxel (Taxotere)FDA Link 03/2012 - 04/2002
10	Tamoxifen FDA LinkGeneric 02/2012 - 01/2002
8	DNA (Deoxyribonucleic Acid)IBA 01/2013 - 01/2007
8	Phosphotransferases (Kinase)IBA 11/2010 - 05/2003
7	Messenger RNA (mRNA)IBA 03/2012 - 06/2005
7	Biological Markers (Surrogate Marker)IBA 02/2012 - 09/2003
6	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2012 - 08/2007
6	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2011 - 06/2003
6	Proteins (Proteins, Gene)IBA 01/2011 - 09/2003
5	capecitabine (Xeloda)FDA Link 03/2012 - 12/2008
5	Epirubicin (Ellence)FDA LinkGeneric 03/2012 - 06/2005
4	Transcription Factors (Transcription Factor)IBA 02/2012 - 09/2003
4	lapatinib (GW572016)FDA Link 09/2011 - 01/2010
4	bevacizumab FDA Link 08/2011 - 07/2010
4	Estrogen ReceptorsIBA 12/2006 - 05/2002
3	ParaffinIBA 01/2013 - 04/2004
3	ixabepilone (BMS 247550)FDA Link 11/2012 - 01/2011
3	everolimus FDA Link 02/2012 - 10/2007
3	Aromatase (CYP19)IBA 02/2012 - 03/2004
3	exemestane (Aromasin)FDA Link 02/2012 - 03/2004
3	Aromatase InhibitorsIBA 02/2012 - 02/2012
3	Selective Estrogen Receptor Modulators (SERM)IBA 02/2012 - 03/2004
3	anastrozole (Arimidex)FDA LinkGeneric 02/2012 - 01/2003
3	DiphosphonatesIBA 01/2012 - 05/2008
3	Leucovorin (Folinic Acid)FDA Link 05/2010 - 06/2004
3	Cadherins (E-Cadherin)IBA 05/2010 - 12/2006
3	Cyclin D1IBA 05/2010 - 10/2002
3	tau Proteins (tau Protein)IBA 09/2009 - 06/2005
2	Erythropoietin FDA Link 08/2011 - 11/2010
2	EndostatinsIBA 08/2011 - 01/2006
2	Cytosine DeaminaseIBA 08/2011 - 01/2006
2	gemcitabine FDA Link 01/2011 - 09/2003
2	Phenobarbital (Luminal)FDA Link 01/2011 - 05/2009
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2011 - 07/2003
2	Tyrosine (L-Tyrosine)FDA Link 01/2011 - 08/2007
2	CytotoxinsIBA 01/2011 - 01/2008
2	erlotinib (CP 358,774)FDA Link 01/2011 - 08/2007
2	Epidermal Growth Factor (EGF)IBA 11/2010 - 10/2007
2	Protein Kinases (Protein Kinase)IBA 11/2010 - 02/2004
2	Small Interfering RNA (siRNA)IBA 11/2010 - 05/2010
2	TegafurIBA 05/2010 - 03/2010
2	UracilIBA 05/2010 - 03/2010
2	thymidine 5'-triphosphate (TTP)IBA 05/2010 - 03/2010
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 05/2009 - 01/2008
2	CyclinsIBA 01/2009 - 10/2006
2	zoledronic acid (zoledronate)FDA Link 06/2008 - 01/2005
2	Dihydrotachysterol (AT 10)IBA 09/2007 - 10/2005
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2007 - 10/2002
2	Cyclin EIBA 01/2007 - 11/2002
2	P-GlycoproteinIBA 01/2007 - 08/2005
2	Methotrexate (Mexate)FDA LinkGeneric 06/2004 - 11/2003
2	Peptide Hydrolases (Proteases)IBA 03/2004 - 09/2003
2	Cell Adhesion MoleculesIBA 03/2004 - 09/2003
2	Telomerase (Telomerase Reverse Transcriptase)IBA 03/2004 - 09/2003
1	Stearoyl-CoA DesaturaseIBA 01/2013
1	Formaldehyde (Formol)FDA Link 01/2013
1	epothilone B (EPO906)IBA 11/2012
1	AngiozymeIBA 09/2012

Therapy/Procedure

91	Drug Therapy (Chemotherapy) 09/2012 - 01/2002
14	Adjuvant Chemotherapy 11/2010 - 05/2002
12	Radiotherapy 09/2011 - 06/2002
12	Mastectomy (Mammectomy) 09/2011 - 01/2002
10	Neoadjuvant Therapy 02/2012 - 10/2002
6	Heterologous Transplantation (Xenotransplantation) 10/2012 - 10/2002
3	Segmental Mastectomy (Lumpectomy) 10/2009 - 10/2002
2	Hematopoietic Stem Cell Transplantation 08/2011 - 11/2004
2	Combination Drug Therapy (Combination Chemotherapy) 05/2011 - 02/2006
2	Aftercare (After-Treatment) 10/2004 - 02/2004