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Toshihiko Hirano Selected Research

Aligeron (AS 2)

12/2011Effects of inorganic and organic arsenic compounds on growth and apoptosis of human T-lymphoblastoid leukemia cells.
9/2011Antiproliferative and anti-invasive effects of inorganic and organic arsenic compounds on human and murine melanoma cells in vitro.
7/2003Arsenic trioxide induces apoptosis in cells of MOLT-4 and its daunorubicin-resistant cell line via depletion of intracellular glutathione, disruption of mitochondrial membrane potential and activation of caspase-3.
2/2003Arsenic trioxide induces apoptosis equally in T lymphoblastoid leukemia MOLT-4 cells and P-gp-expressing daunorubicin-resistant MOLT-4 cells.

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Toshihiko Hirano Research Topics

Disease

11Leukemia
11/2015 - 05/2002
7Myasthenia Gravis
01/2012 - 12/2003
6Neoplasms (Cancer)
11/2015 - 11/2003
5Infection
06/2014 - 06/2006
3Myelodysplastic Syndromes (Myelodysplastic Syndrome)
09/2014 - 01/2003
3Melanoma (Melanoma, Malignant)
01/2012 - 06/2009
3Psoriasis (Pustulosis Palmaris et Plantaris)
10/2011 - 10/2007
2Breast Neoplasms (Breast Cancer)
08/2015 - 01/2015
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
09/2014 - 05/2014
2Cytomegalovirus Infections (Inclusion Disease)
06/2014 - 01/2012
2Septic Shock (Toxic Shock Syndrome)
10/2011 - 06/2006
2Ulcer
07/2010 - 04/2009
2Fibrosis (Cirrhosis)
01/2009 - 01/2006
2Chronic Kidney Failure (Chronic Renal Failure)
01/2009 - 04/2007
2Nephrotic Syndrome (Syndrome, Nephrotic)
12/2008 - 06/2006
2Bacterial Infections (Bacterial Infection)
10/2007 - 06/2006
2Crohn Disease (Crohn's Disease)
05/2004 - 10/2002
1Acute Promyelocytic Leukemia
07/2015
1Pre-Eclampsia (Preeclampsia)
04/2015
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
10/2014
1Substance Withdrawal Syndrome (Withdrawal Symptoms)
08/2014
1Hematologic Neoplasms (Hematological Malignancy)
12/2013
1Sleep Initiation and Maintenance Disorders (Insomnia)
01/2012

Drug/Important Bio-Agent (IBA)

10Tacrolimus (Prograf)FDA LinkGeneric
06/2014 - 12/2003
10P-GlycoproteinIBA
03/2010 - 05/2002
7Cyclosporine (Ciclosporin)FDA LinkGeneric
06/2014 - 12/2003
7Prednisolone (Predate)FDA LinkGeneric
10/2011 - 09/2002
6CalcineurinIBA
02/2010 - 01/2006
5Daunorubicin (Cerubidine)FDA LinkGeneric
11/2015 - 02/2003
5MethylprednisoloneFDA LinkGeneric
08/2014 - 09/2002
4Aligeron (AS 2)IBA
12/2011 - 02/2003
4GlucocorticoidsIBA
10/2008 - 06/2006
4Messenger RNA (mRNA)IBA
05/2004 - 09/2002
3CytokinesIBA
08/2015 - 02/2010
3sofalcone (Solon)IBA
04/2015 - 04/2009
3Arsenicals (Arsenic Compounds)IBA
11/2014 - 09/2011
3arsenic disulfide (realgar)IBA
09/2014 - 02/2014
3arsenic trioxide (Trisenox)FDA Link
01/2013 - 02/2003
3Cholinergic ReceptorsIBA
01/2012 - 02/2010
3AntibodiesIBA
01/2012 - 02/2010
3SuperantigensIBA
10/2007 - 01/2006
3Staphylococcal enterotoxin FIBA
04/2007 - 01/2006
2VitaminsIBA
11/2015 - 01/2012
2Interleukin-10 (Interleukin 10)IBA
08/2015 - 04/2009
2HormonesIBA
08/2015 - 01/2015
2Tretinoin (Retinoic Acid)FDA LinkGeneric
11/2014 - 01/2012
2Hydrocortisone (Cortisol)FDA LinkGeneric
08/2014 - 01/2012
2Dacarbazine (DIC)FDA LinkGeneric
01/2013 - 01/2012
2arsenic acid (arsenate)IBA
12/2011 - 09/2011
2RoxithromycinIBA
10/2011 - 01/2009
2Concanavalin AIBA
10/2011 - 06/2006
2Anti-Bacterial Agents (Antibiotics)IBA
10/2011 - 01/2009
2Chalcone (Benzalacetophenone)IBA
06/2009 - 04/2009
2Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
10/2002 - 09/2002
1Vitamin K 3 (Menadione)FDA Link
11/2015
1Vitamin KFDA Link
11/2015
1PolymersIBA
08/2015
1Interleukin-17 (Interleukin 27)IBA
08/2015
1Interleukin-6 (Interleukin 6)IBA
08/2015
1Interleukin-2 (IL2)IBA
08/2015
1GelatinIBA
08/2015
1delphinidinIBA
07/2015
1arseniteIBA
07/2015
1Tyrosine (L-Tyrosine)FDA Link
04/2015
1Heme Oxygenase-1IBA
04/2015
1Estradiol (Estrace)FDA LinkGeneric
01/2015
1Aromatase (CYP19)IBA
01/2015
1Vitamin EFDA LinkGeneric
01/2015
1Cisplatin (Platino)FDA LinkGeneric
10/2014
1prolinedithiocarbamate (PDTC)IBA
10/2014
1pyrrolidine dithiocarbamic acidIBA
10/2014
1N 30IBA
08/2014
1Adenosine Triphosphate (ATP)IBA
06/2014
1monosomy Chromosome 7IBA
05/2014
1casticinIBA
12/2013
1MicroRNAs (MicroRNA)IBA
11/2013
1Fluorouracil (Carac)FDA LinkGeneric
01/2013
1Methotrexate (Mexate)FDA LinkGeneric
01/2013
1Adrenocorticotropic Hormone (ACTH)FDA Link
01/2012
1Cholecalciferol (Vitamin D3)FDA Link
01/2012
1basiliximabFDA Link
01/2012
1Acetylcysteine (Siran)FDA LinkGeneric
12/2011
1Ascorbic Acid (Vitamin C)FDA LinkGeneric
12/2011
1buthionineIBA
12/2011
1Caspase 3 (Caspase-3)IBA
12/2011
1sulfoxideIBA
12/2011
1Clarithromycin (Biaxin)FDA LinkGeneric
10/2011
1Azithromycin (Zithromax)FDA LinkGeneric
10/2011
1Bromodeoxyuridine (BrdU)IBA
09/2011
1QuercetinIBA
03/2010
1tangeretinIBA
03/2010
1epigallocatechin gallate (epigallocatechin-3-gallate)IBA
03/2010
1baicaleinIBA
03/2010
1wogoninIBA
03/2010
1nobiletinIBA
03/2010

Therapy/Procedure

3Liver Transplantation
01/2009 - 01/2006
2Drug Therapy (Chemotherapy)
01/2013 - 11/2003
2Kidney Transplantation
01/2009 - 04/2007
1Transplants (Transplant)
06/2014
1Transplantation (Transplant Recipients)
06/2014