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Yukihito Higashi Selected Research

Nitroglycerin (Dynamite)

4/2007Sarpogrelate hydrochloride, a selective 5-HT2A antagonist, improves vascular function in patients with peripheral arterial disease.
1/2005Vascular function in patients with lower extremity peripheral arterial disease: a comparison of functions in upper and lower extremities.
10/2004Forearm endothelial function and bone mineral loss in postmenopausal women.
8/2003Myocardial bridging increases the risk of coronary spasm.
4/2003Comparison of forearm endothelial function between premenopausal and postmenopausal women with or without hypercholesterolemia.
3/2003A comparison of low-dose and standard-dose oral estrogen on forearm endothelial function in early postmenopausal women.
10/2002Hormone replacement effects on endothelial function measured in the forearm resistance artery in normocholesterolemic and hypercholesterolemic postmenopausal women.
9/2002Combination therapy of low-dose medroxyprogesterone acetate and oral estrogen does not affect endothelial function in the forearms of postmenopausal women.
5/2002Severity of hypertension affects improved resistance artery endothelial function by angiotensin-converting enzyme inhibition.

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Yukihito Higashi Research Topics

Disease

21Hypertension (High Blood Pressure)
04/2015 - 01/2002
15Atherosclerosis
07/2015 - 05/2003
11Hyperemia
01/2015 - 05/2002
7Cardiovascular Diseases (Cardiovascular Disease)
04/2014 - 01/2006
6Ischemia
01/2013 - 03/2004
4Myocardial Infarction
04/2014 - 04/2005
4Body Weight (Weight, Body)
01/2014 - 01/2002
4Diabetes Mellitus
01/2012 - 04/2005
3Heart Failure
04/2014 - 04/2005
3Coronary Artery Disease (Coronary Atherosclerosis)
01/2012 - 04/2005
3Peripheral Arterial Disease
02/2011 - 04/2006
2Gilbert Disease
05/2014 - 07/2012
2Renovascular Hypertension (Goldblatt Syndrome)
05/2014 - 06/2002
2Stroke (Strokes)
04/2014 - 02/2009
2Neoplasms (Cancer)
02/2013 - 11/2010
2Hyperuricemia
07/2011 - 11/2002
2Thromboangiitis Obliterans (Buerger's Disease)
02/2011 - 01/2011
2Periodontitis
10/2009 - 02/2008
2Spasm (Spasms)
07/2008 - 08/2003
2Insulin Resistance
10/2005 - 07/2003
2Chest Pain (Chest Pains)
12/2003 - 08/2003
1Acute Coronary Syndrome
10/2015
1Angina Pectoris
07/2015
1Hyperaldosteronism (Conn Syndrome)
04/2015
1Adenoma (Adenomas)
04/2015
1Abruptio Placentae (Placental Abruption)
07/2014
1Pre-Eclampsia (Preeclampsia)
07/2014
1Hypoglycemia (Reactive Hypoglycemia)
01/2014
1Coronary Disease (Coronary Heart Disease)
12/2013
1Peritoneal Fibrosis
08/2013
1Colonic Neoplasms (Colon Cancer)
02/2013
1Neoplasm Metastasis (Metastasis)
02/2013
1Inflammation
07/2012
1Carotid Artery Diseases
01/2012
1Carcinoma (Carcinomatosis)
11/2010

Drug/Important Bio-Agent (IBA)

11Acetylcholine (Acetylcholine Chloride)FDA Link
01/2013 - 02/2002
10rho-Associated KinasesIBA
10/2015 - 05/2003
9Nitric Oxide (Nitrogen Monoxide)FDA Link
07/2015 - 01/2002
9Nitroglycerin (Dynamite)FDA LinkGeneric
04/2007 - 05/2002
5Isosorbide Dinitrate (Isordil)FDA LinkGeneric
12/2002 - 02/2002
4CholesterolIBA
12/2013 - 04/2002
4Nitroprusside (Sodium Nitroprusside)FDA LinkGeneric
01/2013 - 03/2004
4Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
04/2005 - 05/2002
3Glucose (Dextrose)FDA LinkGeneric
12/2013 - 07/2003
3Biological Markers (Surrogate Marker)IBA
12/2013 - 01/2012
3Angiotensin IIIBA
04/2005 - 01/2004
2AldosteroneIBA
04/2015 - 12/2012
2BilirubinIBA
05/2014 - 07/2012
2Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
02/2013 - 11/2010
2ReninIBA
12/2012 - 06/2004
2Lipoproteins (Lipoprotein)IBA
07/2012 - 02/2010
2DiureticsIBA
02/2011 - 11/2008
2Amlodipine (Norvasc)FDA LinkGeneric
02/2011 - 05/2002
2sarpogrelateIBA
01/2010 - 04/2007
2Interleukin-6 (Interleukin 6)IBA
10/2009 - 02/2008
2C-Reactive ProteinIBA
10/2009 - 02/2008
2phenylmethylpyrazoloneIBA
02/2009 - 01/2006
2CalciumIBA
11/2008 - 10/2005
2Insulin (Novolin)FDA Link
10/2005 - 04/2002
2Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
04/2005 - 01/2002
2LDL CholesterolIBA
06/2004 - 04/2002
2Nitric Oxide Synthase (NO Synthase)IBA
05/2002 - 01/2002
1isosorbide-5-mononitrate (Ismo)FDA LinkGeneric
07/2015
1MercuryIBA
01/2015
1baysilon (polydimethylsiloxane)IBA
01/2015
1Advanced Glycosylation End ProductsIBA
01/2015
1tranilast (N 5')IBA
07/2014
1erucylphosphocholineIBA
07/2014
1IncretinsIBA
01/2014
1HormonesIBA
01/2014
1ResistinIBA
08/2013
1chlorhexidine gluconate (Dyna-Hex)FDA LinkGeneric
08/2013
1imatinib (Gleevec)FDA Link
02/2013
1QuercetinIBA
01/2013
18-hydroxy-2'-deoxyguanosineIBA
07/2012
1Malondialdehyde (Propanedial)IBA
07/2012
1CreatinineIBA
07/2012
1Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
07/2012
1Allopurinol (Remid)FDA LinkGeneric
02/2012
1Xanthine DehydrogenaseIBA
02/2012
1Uric Acid (Urate)IBA
07/2011
1Calcium Channels (Calcium Channel)IBA
02/2011
1Antihypertensive Agents (Antihypertensives)IBA
02/2011
1OxygenIBA
02/2011
1Losartan (Cozaar)FDA LinkGeneric
02/2011
1Myosins (Myosin)IBA
01/2011
1Myosin-Light-Chain PhosphataseIBA
01/2011
1fasudil (AT 877)IBA
01/2011
1Troleandomycin (TAO)FDA Link
01/2011
1Proliferating Cell Nuclear Antigen (PCNA)IBA
11/2010
1HDL CholesterolIBA
02/2010

Therapy/Procedure

3Sublingual Administration
04/2007 - 05/2002
2Intra-Arterial Infusions
01/2015 - 04/2002
2Transplantation (Transplant Recipients)
02/2013 - 11/2010
2Tissue Therapy (Cell Therapy)
01/2011 - 04/2006
1Coronary Artery Bypass (Coronary Artery Bypass Surgery)
04/2014
1Peritoneal Dialysis
08/2013
1Heterologous Transplantation (Xenotransplantation)
02/2013
1Amputation
02/2011
1Renal Dialysis (Hemodialysis)
02/2011