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Richard Harrop Selected Research

Vaccinia

9/2013Vaccination of castration-resistant prostate cancer patients with TroVax (MVA-5T4) in combination with docetaxel: a randomized phase II trial.
11/2010Vaccination of metastatic renal cancer patients with MVA-5T4: a randomized, double-blind, placebo-controlled phase III study.
10/2009Immune evasion mechanisms in colorectal cancer liver metastasis patients vaccinated with TroVax (MVA-5T4).
9/2009Vaccination of renal cell cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) alone or administered in combination with interferon-alpha (IFN-alpha): a phase 2 trial.
5/2009Vaccination of patients with metastatic renal cancer with modified vaccinia Ankara encoding the tumor antigen 5T4 (TroVax) given alongside interferon-alpha.
1/2009Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma.
11/2008Vaccination of renal cell cancer patients with modified vaccinia ankara delivering tumor antigen 5T4 (TroVax) administered with interleukin 2: a phase II trial.
8/2008Identification and functional validation of MHC class I epitopes in the tumor-associated antigen 5T4.
7/2008Vaccination of prostate cancer patients with modified vaccinia ankara delivering the tumor antigen 5T4 (TroVax): a phase 2 trial.
7/2008Vaccination of colorectal cancer patients with TroVax given alongside chemotherapy (5-fluorouracil, leukovorin and irinotecan) is safe and induces potent immune responses.
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Richard Harrop Research Topics

Disease

22Neoplasms (Cancer)
09/2013 - 02/2005
14Vaccinia
09/2013 - 01/2004
7Renal Cell Carcinoma (Grawitz Tumor)
12/2012 - 11/2008
7Colorectal Neoplasms (Colorectal Cancer)
10/2009 - 05/2006
3Prostatic Neoplasms (Prostate Cancer)
09/2013 - 07/2008
3Kidney Neoplasms (Kidney Cancer)
06/2011 - 05/2009
2Carcinoma (Carcinomatosis)
09/2012 - 05/2006
2Neoplasm Metastasis (Metastasis)
10/2009 - 11/2008
1Impulse Control Disorders (Kleptomania)
03/2014
1Parkinson Disease (Parkinson's Disease)
03/2014
1Anemia
12/2012
1Mesothelioma
08/2012
1Adenocarcinoma
09/2006
1Breast Neoplasms (Breast Cancer)
02/2005
1Melanoma (Melanoma, Malignant)
02/2005
1Smallpox (Variola)
01/2004
1Infection
01/2004

Drug/Important Bio-Agent (IBA)

20AntigensIBA
09/2013 - 01/2006
17TroVax (5T4 cancer vaccine)IBA
09/2013 - 05/2006
5Interleukin-2 (IL2)IBA
12/2012 - 11/2008
3sunitinib (Sutent)FDA Link
12/2012 - 11/2010
2AntibodiesIBA
11/2010 - 09/2006
2Membrane Glycoproteins (Membrane Glycoprotein)IBA
11/2010 - 05/2006
2Interferon-alpha (Interferon Alfa)FDA Link
09/2009 - 05/2009
1Dopamine (Intropin)FDA LinkGeneric
03/2014
1Dopamine Receptors (Dopamine Receptor)IBA
03/2014
1docetaxel (Taxotere)FDA Link
09/2013
1Ferritins (Ferritin)IBA
12/2012
1Hemoglobins (Hemoglobin)IBA
12/2012
1Carbon MonoxideIBA
08/2012
1megakaryocyte potentiating factorIBA
08/2012
1InterferonsIBA
11/2010
1thymidine 5'-triphosphate (TTP)IBA
05/2009
1EpitopesIBA
08/2008
1irinotecan (Camptosar)FDA LinkGeneric
07/2008
1Leucovorin (Folinic Acid)FDA Link
07/2008
1Fluorouracil (Carac)FDA LinkGeneric
07/2008
1HormonesIBA
07/2008
1Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
07/2008
1Prostate-Specific Antigen (Semenogelase)IBA
07/2008
1Viral VaccinesIBA
10/2006
1AutoantigensIBA
01/2006
1S-mephenytoin N-demethylase (CYP2B6)IBA
02/2005
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
02/2005
1Neutralizing AntibodiesIBA
01/2004
1Smallpox VaccineFDA Link
01/2004
1VaccinesIBA
01/2004

Therapy/Procedure

8Immunotherapy
04/2013 - 01/2006
2Drug Therapy (Chemotherapy)
07/2008 - 08/2007
1Castration
09/2013
1Individualized Medicine
04/2013
1Heterologous Transplantation (Xenotransplantation)
09/2012
1Nephrectomy
11/2010
1Aftercare (After-Treatment)
11/2010