John Hardy Selected Research

Alzheimer Disease (Alzheimer's Disease)

09/2008	Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13?
06/2007	A presenilin 1 mutation (L420R) in a family with early onset Alzheimer disease, seizures and cotton wool plaques, but not spastic paraparesis.
05/2007	Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease.
04/2007	A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.
04/2007	Testing for linkage and association across the dihydrolipoyl dehydrogenase gene region with Alzheimer's disease in three sample populations.
02/2007	Putting presenilins centre stage. Introduction to the Talking Point on the role of presenilin mutations in Alzheimer disease.
05/2006	A presenilin-1 mutation (T245P) in transmembrane domain 6 causes early onset Alzheimer's disease.
02/2006	Has the amyloid cascade hypothesis for Alzheimer's disease been proved?
01/2006	Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal.
08/2005	Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls.
07/2005	Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.
03/2005	Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease.
01/2005	Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease.
11/2004	Association of the dihydrolipoamide dehydrogenase gene with Alzheimer's disease in an Ashkenazi Jewish population.
11/2004	Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family.
07/2004	A new presenilin Alzheimer's disease case confirms the helical alignment of pathogenic mutations in transmembrane domain 5.
03/2004	An association study of the cholesteryl ester transfer protein TaqI B polymorphism with late onset Alzheimer's disease.
01/2004	Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease.
07/2003	Biological markers for therapeutic trials in Alzheimer's disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer's disease.
10/2002	Possible association between genetic variability at the apolipoprotein(a) locus and Alzheimer's disease in apolipoprotein E2 carriers.
09/2002	An association study of a functional catalase gene polymorphism, -262C-->T, and patients with Alzheimer's disease.
07/2002	The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.
04/2002	No association between the lipoprotein lipase S447X polymorphism and Alzheimer's disease.

Articles by Research Topic

Disease

23	Alzheimer Disease (Alzheimer's Disease) 09/2008 - 04/2002
3	Parkinson Disease (Parkinson's Disease) 06/2006 - 10/2003
3	Dementia (Dementias) 01/2006 - 03/2002
3	Parkinsonian Disorders (Parkinsonism) 02/2005 - 04/2003
2	Amyloidosis 01/2008 - 09/2005
2	Neuroblastoma 01/2004 - 05/2003
1	Dystonia (Limb Dystonia) 01/2008
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2008
1	Seizures (Seizure) 06/2007
1	Spastic Paraparesis 06/2007
1	Atrophy 06/2007
1	Stroke (Strokes) 09/2005
1	Dystonia Musculorum Deformans (Torsion Dystonia) 05/2003
1	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2002

Drug/Important Bio-Agent (IBA)

5	alpha-SynucleinIBA 02/2005 - 05/2003
4	Presenilin-1IBA 06/2007 - 03/2002
4	Amyloid (Amyloid Fibrils)IBA 02/2006 - 07/2002
2	Apolipoproteins E (ApoE)IBA 09/2008 - 04/2007
2	Dihydrolipoamide Dehydrogenase (Lipoamide Dehydrogenase)IBA 04/2007 - 11/2004
2	PresenilinsIBA 02/2007 - 07/2004
2	Insulysin (Insulin-Degrading Enzyme)IBA 01/2006 - 07/2005
1	Dihydroxyphenylalanine (Dopa)IBA 01/2008
1	protein TDP-43IBA 01/2008
1	alpha-Macroglobulins (alpha 2 Macroglobulin)IBA 01/2008
1	ApolipoproteinsIBA 06/2007
1	LDL-Receptor Related Protein 1 (LDL-Receptor Related Protein)IBA 05/2007
1	Semaphorins (Semaphorin)IBA 06/2006
1	Insulin (Novolin)FDA Link 01/2006
1	TeaIBA 09/2005
1	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 09/2005
1	Type 4 Cyclic Nucleotide PhosphodiesterasesIBA 09/2005
1	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 09/2005
1	glucuronyl glucosamine glycan sulfate (Vessel)IBA 08/2005
1	Apolipoprotein E4IBA 07/2005
1	Carrier Proteins (Binding Protein)IBA 03/2005
1	cholesterol 25-hydroxylaseIBA 01/2005
1	Glyceraldehyde-3-Phosphate Dehydrogenases (GAPD)IBA 11/2004
1	Cholesterol Ester Transfer ProteinsIBA 03/2004
1	ManganeseIBA 01/2004
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2004
1	terthienyl (alpha-T)IBA 01/2004
1	Biological Markers (Surrogate Marker)IBA 07/2003
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 05/2003
1	Dopamine (Intropin)FDA LinkGeneric 05/2003
1	Carbon MonoxideIBA 05/2003
1	Levodopa (L Dopa)FDA LinkGeneric 04/2003
1	Apoprotein(a) (Apolipoprotein (a))IBA 10/2002
1	Apolipoprotein E2IBA 10/2002
1	CatalaseIBA 09/2002
1	Proteins (Proteins, Gene)IBA 06/2002
1	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 04/2002
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 03/2002

Therapy/Procedure

1	Denervation 04/2004
1	Therapeutics 07/2002