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Paul W Hake Selected Research

Myocardial Reperfusion Injury

11/2007Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt.
3/2005Inhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration.
4/2004Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1.
2/2002Sesquiterpene lactone parthenolide, an inhibitor of IkappaB kinase complex and nuclear factor-kappaB, exerts beneficial effects in myocardial reperfusion injury.

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Paul W Hake Research Topics

Disease

10Inflammation
04/2011 - 02/2003
9Sepsis (Septicemia)
08/2015 - 09/2003
7Myocardial Ischemia (Ischemic Heart Diseases)
01/2014 - 02/2002
7Lung Injury
04/2011 - 09/2003
6Reperfusion Injury
01/2014 - 05/2003
6Hemorrhage
04/2011 - 01/2008
5Hypotension (Low Blood Pressure)
05/2011 - 05/2002
5Hemorrhagic Shock
05/2011 - 10/2008
4Ischemia
05/2011 - 02/2002
4Pneumonia (Pneumonitis)
05/2011 - 10/2008
4Shock
06/2009 - 02/2003
4Myocardial Reperfusion Injury
11/2007 - 02/2002
3Endotoxemia
04/2014 - 05/2007
3Colitis
01/2008 - 05/2003
3Septic Shock (Toxic Shock Syndrome)
05/2007 - 05/2002
2Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
12/2004 - 05/2003
2Multiple Organ Failure (MODS)
12/2003 - 09/2003
1Infection
04/2014
1Atherosclerosis
04/2011
1Dermatitis
04/2011
1Ulcer
01/2008
1Edema
01/2008
1Diabetic Neuropathies (Diabetic Neuropathy)
05/2007
1Acquired Immunodeficiency Syndrome (AIDS)
05/2007

Drug/Important Bio-Agent (IBA)

8PPAR gammaIBA
01/2010 - 12/2003
7NF-kappa B (NF-kB)IBA
10/2010 - 05/2002
5Transcription Factor AP-1 (Transcription Factor AP 1)IBA
01/2008 - 12/2003
4Peroxidase (Myeloperoxidase)IBA
01/2014 - 03/2005
4LigandsIBA
01/2014 - 12/2003
4ciglitazoneIBA
01/2010 - 12/2003
4Poly Adenosine Diphosphate RiboseIBA
03/2005 - 05/2003
3liver X receptorIBA
08/2015 - 08/2006
3C-PeptideIBA
04/2014 - 05/2007
3Transcription Factors (Transcription Factor)IBA
11/2010 - 08/2006
3TeaIBA
01/2008 - 01/2004
3DNA (Deoxyribonucleic Acid)IBA
11/2007 - 02/2003
3Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
03/2005 - 02/2003
3parthenolideIBA
09/2003 - 02/2002
2Interleukin-6 (Interleukin 6)IBA
05/2011 - 10/2008
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
10/2010 - 05/2007
2Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
10/2008 - 05/2007
2epigallocatechin gallate (epigallocatechin-3-gallate)IBA
01/2008 - 09/2007
215-deoxyprostaglandin J2IBA
11/2007 - 07/2005
2Creatine Kinase (Creatine Phosphokinase)IBA
03/2002 - 02/2002
1ZincIBA
04/2014
1Troponin IIBA
01/2014
1LeptinIBA
10/2012
1Interleukin-1 (Interleukin 1)IBA
05/2011
1TO-901317IBA
04/2011
1Peroxisome Proliferator-Activated Receptors (PPAR)IBA
11/2010
1AdipokinesIBA
11/2010
1AdiponectinIBA
11/2010
1Phosphotransferases (Kinase)IBA
11/2010
1PPAR deltaIBA
10/2010
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
06/2009
1cyclopentenoneIBA
06/2009
1Interleukin-10 (Interleukin 10)IBA
10/2008
1Protein Kinases (Protein Kinase)IBA
10/2008
1Catechin (Z 7300)IBA
01/2008
1Trinitrobenzenesulfonic AcidIBA
01/2008
1HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA
11/2007
1Insulin (Novolin)FDA Link
05/2007
1ProinsulinIBA
05/2007
11,5-dihydroxyisoquinolineIBA
03/2005
13-aminobenzamideIBA
03/2005
1gallocatechol (epigallocatechin)IBA
01/2004
115-deoxy-delta(12,14)-prostaglandin J2IBA
12/2003
1Peroxynitrous Acid (Peroxynitrite)IBA
02/2003
1Escherichia coli endotoxinIBA
05/2002
1Norepinephrine (Noradrenaline)FDA LinkGeneric
05/2002
1Nitric Oxide (Nitrogen Monoxide)FDA Link
03/2002
1Nitric Oxide Synthase (NO Synthase)IBA
03/2002
1I-kappa B KinaseIBA
02/2002

Therapy/Procedure

8Ligation
08/2015 - 09/2003
4Resuscitation
05/2011 - 06/2009
2Rectal Administration
01/2008 - 05/2003