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Gilles J Guillemin Selected Research

Quinolinic Acid

1/2015Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans.
9/2014Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons.
1/2014Quinolinic acid toxicity on oligodendroglial cells: relevance for multiple sclerosis and therapeutic strategies.
6/2013The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress.
4/2013Connecting inflammation with glutamate agonism in suicidality.
1/2013Characterization of the kynurenine pathway and quinolinic Acid production in macaque macrophages.
1/2013Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's disease brain.
4/2012Quinolinic acid: neurotoxicity.
1/2011Effects of Kynurenine Pathway Inhibition on NAD Metabolism and Cell Viability in Human Primary Astrocytes and Neurons.
1/2011Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?
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Gilles J Guillemin Research Topics

Disease

13Alzheimer Disease (Alzheimer's Disease)
04/2015 - 01/2002
10Inflammation
06/2015 - 08/2009
7Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
07/2015 - 01/2005
7Parkinson Disease (Parkinson's Disease)
06/2015 - 01/2011
7Neoplasms (Cancer)
01/2015 - 11/2007
7Neurodegenerative Diseases (Neurodegenerative Disease)
01/2015 - 03/2003
5AIDS Dementia Complex
01/2009 - 01/2003
4Amyloid Plaque
01/2013 - 01/2002
3Infection
10/2014 - 01/2012
3Multiple Sclerosis
01/2014 - 01/2010
3Parkinsonian Disorders (Parkinsonism)
01/2013 - 01/2011
3Neuroblastoma
01/2013 - 02/2007
3Brain Diseases (Brain Disorder)
01/2013 - 07/2009
2Obesity
10/2015 - 07/2012
2Demyelinating Diseases (Demyelinating Disease)
06/2014 - 01/2012
2Glioma (Gliomas)
01/2014 - 06/2013
2Brain Neoplasms (Brain Tumor)
01/2014 - 11/2012
2Huntington Disease (Huntington's Disease)
06/2013 - 01/2009
2Schizophrenia (Dementia Praecox)
04/2012 - 01/2009
2Depressive Disorder (Melancholia)
04/2012 - 01/2011
1Cerebral Malaria
02/2016
1Anoxia (Hypoxia)
02/2016
1Insulin Resistance
10/2015
1Body Weight (Weight, Body)
06/2015
1Multiple System Atrophy
03/2015
1Astrocytoma (Pilocytic Astrocytoma)
01/2015
1Breast Neoplasms (Breast Cancer)
01/2015
1Starvation
01/2015
1Colorectal Neoplasms (Colorectal Cancer)
01/2015
1Brain Injuries (Brain Injury)
01/2015
1Optic Neuritis (Retrobulbar Neuritis)
06/2014
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
01/2014
1Nervous System Diseases (Neurological Disorders)
01/2014
1Disease Progression
11/2013
1Dementia (Dementias)
01/2013
1Pervasive Child Development Disorders
01/2013
1Autistic Disorder (Autism)
01/2013
1Glioblastoma (Glioblastoma Multiforme)
08/2012
1Tuberculosis (Tuberculoses)
01/2012
1Major Depressive Disorder (Major Depressive Disorders)
01/2011

Drug/Important Bio-Agent (IBA)

28KynurenineIBA
10/2015 - 01/2002
21Quinolinic AcidIBA
01/2015 - 01/2002
15Tryptophan (L-Tryptophan)FDA Link
06/2015 - 01/2003
7NeurotoxinsIBA
01/2015 - 12/2003
6CytokinesIBA
02/2016 - 08/2009
6NAD (NADH)IBA
01/2015 - 01/2013
5Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA
10/2015 - 08/2009
5EnzymesIBA
10/2015 - 11/2007
3Interferon-gamma (Interferon, gamma)IBA
02/2016 - 08/2009
3N-Methylaspartate (NMDA)IBA
06/2013 - 01/2011
3Amyloid beta-PeptidesIBA
08/2009 - 01/2002
2kynurenine-oxoglutarate transaminaseIBA
10/2015 - 01/2014
2Kynurenine 3-Monooxygenase (Kynurenine 3 Monooxygenase)IBA
10/2015 - 01/2014
2kynureninaseIBA
10/2015 - 01/2014
21- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
06/2015 - 01/2013
2Amyloid (Amyloid Fibrils)IBA
04/2015 - 10/2012
23-hydroxykynurenineIBA
01/2015 - 06/2013
2Tryptophan Oxygenase (Tryptophan 2,3 Dioxygenase)IBA
01/2015 - 01/2013
2alpha-SynucleinIBA
02/2014 - 01/2013
2Kynurenic Acid (Kynurenate)IBA
04/2013 - 01/2013
2Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA
11/2012 - 10/2011
2Interleukin-6 (Interleukin 6)IBA
08/2012 - 01/2011
2CholesterolIBA
01/2009 - 02/2007
1InterferonsIBA
02/2016
1Chemokine CXCL10IBA
02/2016
1Lymphotoxin-alpha (Lymphotoxin)IBA
02/2016
1myosin VIIBA
07/2015
1Phosphotransferases (Kinase)IBA
05/2015
1Leucine (L-Leucine)FDA Link
05/2015
1SynucleinsIBA
03/2015
1Ethanol (Ethyl Alcohol)IBA
01/2015
1tebufenozide (Mimic)IBA
10/2014
1oligodendrocyte-myelin glycoproteinIBA
06/2014
1Oligoclonal BandsIBA
06/2014
1AntibodiesIBA
06/2014
1AntigensIBA
06/2014
1CopperIBA
01/2014
1IronIBA
01/2014
1Alkylating AgentsIBA
06/2013
1temozolomide (Temodar)FDA LinkGeneric
06/2013
1nicotinate-nucleotide diphosphorylase (carboxylating)IBA
06/2013
1Glutamic Acid (Glutamate)FDA Link
04/2013
1Alanine (L-Alanine)FDA Link
01/2013
1Lamivudine (3TC)FDA Link
01/2013
1HesperidinIBA
01/2013
1Biological Markers (Surrogate Marker)IBA
01/2013
1Carbon MonoxideIBA
01/2013
1Stavudine (Zerit)FDA LinkGeneric
01/2013
1picolinic acid (chromium picolinate)IBA
01/2013
1RotenoneIBA
01/2013
1flavanoneIBA
01/2013
1Interleukin-8 (Interleukin 8)IBA
08/2012
1p38 Mitogen-Activated Protein KinasesIBA
08/2012
1Protein Kinases (Protein Kinase)IBA
08/2012
1Tetrachlorodibenzodioxin (TCDD)IBA
10/2011
1tranilast (N 5')IBA
01/2011
1Interleukin-1 (Interleukin 1)IBA
01/2011
1Glutamate Receptors (Glutamate Receptor)IBA
01/2011

Therapy/Procedure

1Immunotherapy
01/2015
1Transplantation (Transplant Recipients)
01/2012