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Sergei Gryaznov Selected Research

GRN163

11/2005Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma.
1/2004Telomerase inhibition with an oligonucleotide telomerase template antagonist: in vitro and in vivo studies in multiple myeloma and lymphoma.
10/2003Effects of oligonucleotide N3'-->P5' thio-phosphoramidate (GRN163) targeting telomerase RNA in human multiple myeloma cells.
7/2003A novel telomerase template antagonist (GRN163) as a potential anticancer agent.
5/2003Oligonucleotide N3' --> P5' thio-phosphoramidate telomerase template antagonists as potential anticancer agents.

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Sergei Gryaznov Research Topics

Disease

7Neoplasms (Cancer)
08/2008 - 05/2003
2Adenocarcinoma
08/2008 - 03/2006
2Multiple Myeloma
01/2004 - 10/2003
1Breast Neoplasms (Breast Cancer)
03/2006
1Hepatocellular Carcinoma (Hepatoma)
11/2005
1Neoplasm Metastasis (Metastasis)
09/2005
1Lung Neoplasms (Lung Cancer)
09/2005
1Non-Hodgkin Lymphoma (Lymphosarcoma)
01/2004
1Lymphoma (Lymphomas)
01/2004
1Prostatic Neoplasms (Prostate Cancer)
07/2003

Drug/Important Bio-Agent (IBA)

7Telomerase (Telomerase Reverse Transcriptase)IBA
08/2008 - 05/2003
5GRN163IBA
11/2005 - 05/2003
2phosphoramidic acidIBA
11/2005 - 10/2003
1LuciferasesIBA
09/2005
1RNA (Ribonucleic Acid)IBA
10/2003
1telomerase RNA (bTR)IBA
10/2003
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
05/2003

Therapy/Procedure

4Heterologous Transplantation (Xenotransplantation)
11/2005 - 07/2003
1Lasers (Laser)
08/2008
1Drug Therapy (Chemotherapy)
11/2005