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Hinrich Gronemeyer Selected Research

Retinoids

8/2015Modulation of Retinoic Acid Receptor Subtypes by 5- and 8-Substituted (Naphthalen-2-yl)-based Arotinoids.
8/2011Design and stereoselective synthesis of retinoids with ferrocene or N-butylcarbazole pharmacophores that induce post-differentiation apoptosis in acute promyelocytic leukemia cells.
1/2011Retinoic acid receptor modulators: a perspective on recent advances and promises.
1/2010Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms.
10/2009C3 halogen and c8'' substituents on stilbene arotinoids modulate retinoic Acid receptor subtype function.
1/2008Retinoic acid analogues inhibit human herpesvirus 8 replication.
11/2004Retinoids: potential in cancer prevention and therapy.
11/2004RARbeta ligand-binding domain bound to an SRC-1 co-activator peptide: purification, crystallization and preliminary X-ray diffraction analysis.
8/2004Structure-activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells.
8/2004Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL.
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Hinrich Gronemeyer Research Topics

Disease

36Neoplasms (Cancer)
04/2015 - 05/2002
10Acute Promyelocytic Leukemia
08/2015 - 05/2002
6Leukemia
01/2011 - 02/2004
5Metabolic Diseases (Metabolic Disease)
01/2012 - 10/2007
4Breast Neoplasms (Breast Cancer)
04/2015 - 08/2004
3Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
10/2005 - 02/2004
2Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2012 - 01/2007
2Obesity
01/2012 - 11/2004
2Genetic Translocation (Chromosomal Translocation)
02/2004 - 01/2004
1Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous)
08/2015
1Lymphoma (Lymphomas)
01/2015
1Insulin Resistance
01/2012
1Hepatomegaly
01/2012
1Skin Diseases
01/2011
1Colonic Neoplasms (Colon Cancer)
02/2010
1Neuroblastoma
04/2009
1Infection
01/2008
1Kaposi Sarcoma (Kaposi's Sarcoma)
01/2008
1Melanoma (Melanoma, Malignant)
11/2007
1Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
01/2007

Drug/Important Bio-Agent (IBA)

13RetinoidsIBA
08/2015 - 05/2002
9Tretinoin (Retinoic Acid)FDA LinkGeneric
08/2015 - 05/2002
6LigandsIBA
08/2011 - 01/2007
5Histone Deacetylases (Histone Deacetylase)IBA
02/2013 - 01/2005
4ChromatinIBA
04/2015 - 08/2004
4Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2014 - 10/2005
3Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
01/2012 - 11/2004
3Retinoid X Receptors (Retinoid X Receptor)IBA
01/2011 - 10/2005
3promyelocytic leukemia-retinoic acid receptor alpha fusion oncoproteinIBA
02/2010 - 05/2002
3retinoic acid receptor alphaIBA
11/2007 - 02/2004
3Histone Deacetylase InhibitorsIBA
01/2007 - 01/2005
2PeptidesIBA
01/2015 - 02/2010
2Carbon MonoxideIBA
06/2014 - 01/2011
2Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
02/2013 - 01/2007
24- (2- (5,6,7,8- tetrahydro- 5,5,8,8- tetramethyl- 2- naphthalenyl)- 1- propenyl)benzoic acidIBA
09/2007 - 12/2004
2Proteins (Proteins, Gene)IBA
07/2007 - 02/2004
1bexarotene (LGD1069)FDA Link
08/2015
1HeterochromatinIBA
04/2015
1Anti-Obesity Agents (Antiobesity Drugs)IBA
01/2012
1HormonesIBA
01/2012
1polyphenolsIBA
01/2012
1Triglycerides (Triacylglycerol)IBA
01/2012
1Caspase 3 (Caspase-3)IBA
01/2012
1Cyclin B1IBA
01/2012
1TNF-Related Apoptosis-Inducing LigandIBA
09/2011
1decitabine (5-aza-2'-deoxycytidine)FDA Link
09/2011
1DNA (Deoxyribonucleic Acid)IBA
09/2011
1ferroceneIBA
08/2011
1Transcription Factors (Transcription Factor)IBA
07/2011
1resveratrolIBA
02/2010
1Etoposide (VP 16)FDA LinkGeneric
01/2010
1NF-kappa B (NF-kB)IBA
01/2010
1Abortifacient Agents (Abortifacients)IBA
01/2010
1Contraceptive Agents (Contraceptives)IBA
01/2010
1U 0126 (UO 126)IBA
09/2009
1AntigensIBA
11/2007
1CarbonIBA
09/2007
1SiliconIBA
09/2007
14- (2- (5,6,7,8- tetrahydro- 3,5,5,8,8- pentamethyl- 2- naphthalenyl)- 1- propenyl)benzoic acidIBA
09/2007
1Retinoic Acid Receptors (Retinoic Acid Receptor)IBA
01/2007
1retinoic acid receptor betaIBA
01/2007
1Messenger RNA (mRNA)IBA
12/2005
1Initiator CaspasesIBA
10/2005
1TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA
10/2005
1Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
10/2005
1Phosphodiesterase InhibitorsIBA
10/2005
1Antineoplastic Agents (Antineoplastics)IBA
08/2004
1Interferon Regulatory Factor-1 (Interferon Regulatory Factor 1)IBA
08/2004
1Histones (Histone)IBA
08/2004
1InterferonsIBA
08/2004

Therapy/Procedure

3Heterologous Transplantation (Xenotransplantation)
12/2011 - 09/2009
2Chemoprevention
01/2010 - 11/2004
1Radiotherapy
01/2008
1Drug Therapy (Chemotherapy)
02/2004