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Aron Goldhirsch Selected Research

letrozole (Femara)

12/2015ESR1 and ESR2 polymorphisms in the BIG 1-98 trial comparing adjuvant letrozole versus tamoxifen or their sequence for early breast cancer.
10/2015Intermittent Letrozole Administration as Adjuvant Endocrine Therapy for Postmenopausal Women With Hormone Receptor-Positive Early Breast Cancer: A Biologic Study.
9/2015Relative Effectiveness of Letrozole Compared With Tamoxifen for Patients With Lobular Carcinoma in the BIG 1-98 Trial.
6/2015CYP19A1 polymorphisms and clinical outcomes in postmenopausal women with hormone receptor-positive breast cancer in the BIG 1-98 trial.
8/2013Personalized adjuvant therapies: lessons from the past: the opening address by the St. Gallen 2013 award recipient.
11/2012Obesity and risk of recurrence or death after adjuvant endocrine therapy with letrozole or tamoxifen in the breast international group 1-98 trial.
3/2012CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the breast international group 1-98 trial.
11/2011Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8·1 years median follow-up.
4/2011Letrozole plus GnRH analogue as preoperative and adjuvant therapy in premenopausal women with ER positive locally advanced breast cancer.
3/2011Analyses adjusting for selective crossover show improved overall survival with adjuvant letrozole compared with tamoxifen in the BIG 1-98 study.
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Aron Goldhirsch Research Topics

Disease

137Breast Neoplasms (Breast Cancer)
12/2015 - 09/2002
69Neoplasms (Cancer)
12/2015 - 03/2003
7Neoplasm Metastasis (Metastasis)
11/2014 - 09/2002
6Carcinoma (Carcinomatosis)
04/2013 - 03/2003
5Disease Progression
06/2014 - 11/2007
4Ductal Carcinoma
09/2015 - 07/2009
4Hypertension (High Blood Pressure)
08/2013 - 12/2007
3Lobular Carcinoma
09/2015 - 10/2009
3Bone Fractures (Bone Fracture)
04/2008 - 06/2003
3Hypercholesterolemia
12/2007 - 12/2005
3Amenorrhea
07/2007 - 03/2006
2Arthralgia (Joint Pain)
07/2015 - 02/2007
2Venous Thromboembolism
10/2007 - 10/2005
2Hemorrhage
02/2007 - 12/2005
2Hot Flashes
02/2007 - 01/2007
2Endometrial Neoplasms (Endometrial Cancer)
12/2005 - 12/2004
2Thromboembolism
12/2005 - 06/2003
1Bone Resorption
02/2015
1Osteolysis
02/2015
1Osteoporosis
04/2014
1Melanoma (Melanoma, Malignant)
08/2013
1Prostatic Neoplasms (Prostate Cancer)
08/2013
1Obesity
11/2012
1Diarrhea
06/2012

Drug/Important Bio-Agent (IBA)

42Estrogens (Estrogen)FDA Link
12/2015 - 03/2003
35HormonesIBA
12/2015 - 06/2004
34TamoxifenFDA LinkGeneric
12/2015 - 06/2003
24letrozole (Femara)FDA LinkGeneric
12/2015 - 12/2005
22Progesterone Receptors (Progesterone Receptor)IBA
10/2015 - 03/2003
17Fluorouracil (Carac)FDA LinkGeneric
08/2015 - 04/2003
15Cyclophosphamide (Cytoxan)FDA LinkGeneric
08/2015 - 04/2003
14trastuzumab (Herceptin)FDA Link
10/2013 - 10/2005
11Cisplatin (Platino)FDA LinkGeneric
08/2015 - 11/2006
11Epidermal Growth Factor Receptor (EGF Receptor)IBA
10/2014 - 11/2006
10Methotrexate (Mexate)FDA LinkGeneric
09/2012 - 09/2002
8Epirubicin (Ellence)FDA LinkGeneric
08/2015 - 01/2006
7Phenobarbital (Luminal)FDA Link
02/2014 - 04/2012
6capecitabine (Xeloda)FDA Link
06/2015 - 04/2002
5DNA (Deoxyribonucleic Acid)IBA
12/2015 - 06/2010
5ProgesteroneFDA LinkGeneric
08/2015 - 09/2007
5bevacizumabFDA Link
06/2015 - 10/2008
5VaccinesIBA
01/2014 - 09/2007
4exemestane (Aromasin)FDA Link
07/2015 - 09/2003
4vinorelbine (Navelbine)FDA LinkGeneric
06/2015 - 02/2006
4Aromatase (CYP19)IBA
07/2014 - 12/2005
4AntigensIBA
01/2014 - 10/2009
4Cancer VaccinesIBA
01/2014 - 12/2007
4Aromatase InhibitorsIBA
12/2013 - 12/2007
4pegylated liposomal doxorubicinIBA
04/2013 - 12/2010
4glucuronyl glucosamine glycan sulfate (Vessel)IBA
06/2008 - 06/2004
3Paclitaxel (Taxol)FDA LinkGeneric
08/2015 - 09/2008
3Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
10/2013 - 11/2006
3Neoplasm Antigens (Tumor Antigens)IBA
08/2013 - 12/2007
31-dodecylpyridoxal (PLD)IBA
04/2013 - 12/2010
3Carbon MonoxideIBA
04/2013 - 08/2011
3fulvestrant (Faslodex)FDA Link
10/2012 - 11/2007
3erlotinib (CP 358,774)FDA Link
06/2012 - 11/2006
3Gonadotropin-Releasing Hormone (GnRH)FDA Link
04/2011 - 12/2003
3Doxorubicin (Adriamycin)FDA LinkGeneric
12/2010 - 01/2008
3Biological Markers (Surrogate Marker)IBA
12/2009 - 03/2003
3Leucovorin (Folinic Acid)FDA Link
12/2008 - 09/2002
3Goserelin (Zoladex)FDA Link
03/2008 - 12/2003
2docetaxel (Taxotere)FDA Link
08/2015 - 01/2008
2collagen type I trimeric cross-linked peptideIBA
04/2014 - 06/2003
2AntibodiesIBA
01/2014 - 08/2013
2anastrozole (Arimidex)FDA LinkGeneric
10/2012 - 06/2004
2Hemoglobins (Hemoglobin)IBA
06/2012 - 01/2008
2Triptorelin (Trelstar)FDA Link
12/2010 - 04/2010
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2009 - 06/2004
2taxaneIBA
03/2009 - 01/2008
2AnthracyclinesIBA
03/2009 - 05/2008
2Estrogen ReceptorsIBA
12/2008 - 11/2006
2Toremifene (Fareston)FDA Link
02/2006 - 12/2004
1Estrogen Receptor alphaIBA
12/2015
1Estradiol (Estrace)FDA LinkGeneric
10/2015
1EstramustineFDA Link
02/2015
1DiphosphonatesIBA
02/2015
1denosumabFDA Link
02/2015
1Alkaline PhosphataseIBA
04/2014
1OsteocalcinIBA
04/2014
1HLA-G antigen (HLA G)IBA
10/2013
1sunitinib (Sutent)FDA Link
10/2013
1Monoclonal AntibodiesIBA
08/2013
1sipuleucel-T (APC8015)FDA Link
08/2013
1Immunologic Factors (Immunomodulators)IBA
08/2013
1Antihypertensive Agents (Antihypertensives)IBA
08/2013
1ipilimumabIBA
08/2013
1thymidine 5'-triphosphate (TTP)IBA
11/2012
1Epidermal Growth Factor (EGF)IBA
10/2012

Therapy/Procedure

69Drug Therapy (Chemotherapy)
07/2015 - 09/2002
21Adjuvant Chemotherapy
08/2015 - 04/2003
5Immunotherapy
01/2014 - 09/2007
4Mastectomy (Mammectomy)
11/2014 - 02/2009
3Mammaplasty (Breast Reconstruction)
10/2015 - 08/2011
3Radiotherapy
10/2013 - 05/2007
3Neoadjuvant Therapy
02/2011 - 04/2006
3Catheters
10/2007 - 10/2005
2Tissue Therapy (Cell Therapy)
01/2014 - 08/2013
2Therapeutics
02/2012 - 07/2006
2Segmental Mastectomy (Lumpectomy)
02/2009 - 05/2005