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Greg A Gerhardt Selected Research

Glial Cell Line-Derived Neurotrophic Factor (GDNF)

3/2013Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF.
2/2012Enhanced dopamine transporter activity in middle-aged Gdnf heterozygous mice.
1/2010Dopamine neuron stimulating actions of a GDNF propeptide.
4/2007Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal.
12/2006Point source concentration of GDNF may explain failure of phase II clinical trial.
1/2006Unilateral intraputaminal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year each of treatment and withdrawal.
8/2005Trophic factor distribution predicts functional recovery in parkinsonian monkeys.
2/2005Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor.
12/2004Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease.
7/2004Striatal GDNF administration increases tyrosine hydroxylase phosphorylation in the rat striatum and substantia nigra.
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Greg A Gerhardt Research Topics

Disease

19Parkinson Disease (Parkinson's Disease)
03/2013 - 01/2002
6Neurodegenerative Diseases (Neurodegenerative Disease)
07/2012 - 10/2002
4Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
08/2014 - 03/2005
4Brain Injuries (Brain Injury)
04/2012 - 05/2010
3Dyskinesias (Dyskinesia)
01/2013 - 02/2009
2Atrophy
03/2012 - 02/2007
2Ataxia (Dyssynergia)
03/2012 - 10/2006
2Epilepsy (Aura)
07/2011 - 07/2011
2Pain (Aches)
07/2011 - 06/2004
2Parkinsonian Disorders (Parkinsonism)
02/2008 - 08/2005
1Inflammation
03/2013
1Dementia (Dementias)
03/2012
1Hypersensitivity (Allergy)
01/2012
1Anxiety Disorders (Anxiety Disorder)
07/2011
1Fibromyalgia (Fibrositis)
07/2011
1Diabetic Neuropathies (Diabetic Neuropathy)
07/2011
1Postherpetic Neuralgia
07/2011
1Major Depressive Disorder (Major Depressive Disorders)
07/2011
1Schizophrenia (Dementia Praecox)
12/2010
1Seizures (Seizure)
01/2010
1Ischemia
01/2010
1Anoxia (Hypoxia)
11/2007
1Stroke (Strokes)
11/2007
1Hypokinesia (Bradykinesia)
11/2006

Drug/Important Bio-Agent (IBA)

14Dopamine (Intropin)FDA LinkGeneric
01/2013 - 01/2002
12Glutamic Acid (Glutamate)FDA Link
08/2014 - 11/2007
12Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
03/2013 - 01/2002
4Levodopa (L Dopa)FDA LinkGeneric
01/2013 - 10/2002
3PotassiumIBA
01/2013 - 05/2010
3Amphetamine (Amfetamine)FDA LinkGeneric
04/2007 - 03/2005
2Neurotransmitter Agents (Neurotransmitter)IBA
01/2010 - 12/2007
2Nerve Growth Factors (Neurotrophins)IBA
01/2010 - 06/2004
21- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
02/2008 - 11/2006
2SaltsIBA
04/2007 - 03/2005
2AdderallIBA
04/2007 - 03/2005
2Dextroamphetamine (Dexedrine)FDA LinkGeneric
04/2007 - 03/2005
2IronIBA
02/2007 - 10/2005
1Carbon MonoxideIBA
01/2013
1CalciumIBA
04/2012
1salicylhydroxamic acid (SHAM)IBA
03/2012
1Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA
03/2012
1pregabalin (Lyrica)FDA Link
07/2011
1Prostaglandins B (PGB)IBA
07/2011
1gabapentin (Neurontin)FDA LinkGeneric
07/2011
1Biogenic Amines (Biogenic Amine)IBA
07/2011
1Potassium ChlorideFDA LinkGeneric
05/2010
1antineoplaston A10 (A 10)IBA
02/2010
1Trichloroethylene (Trichloroethene)IBA
02/2008
1NeurotoxinsIBA
02/2008
1ApomorphineIBA
11/2006
1Dopamine Agents (Dopaminergic Agents)IBA
11/2006
1Ethanol (Ethyl Alcohol)IBA
10/2006
1Methylphenidate (Ritalin)FDA LinkGeneric
03/2005
1Bone Morphogenetic Protein 7IBA
06/2004
1Proteins (Proteins, Gene)IBA
01/2003
1PeptidesIBA
01/2003

Therapy/Procedure

2Microelectrodes
01/2012 - 05/2010
1Therapeutics
07/2011
1Caloric Restriction
12/2004