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Alfredo Fusco Selected Research

Cyclin-Dependent Kinase Inhibitor p27

9/2007MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle.
6/2007Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer.
6/2004Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells.
10/2002Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.

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Alfredo Fusco Research Topics

Disease

76Neoplasms (Cancer)
08/2015 - 01/2002
40Carcinoma (Carcinomatosis)
11/2015 - 01/2002
25Thyroid Neoplasms (Thyroid Cancer)
02/2015 - 09/2002
14Adenoma (Adenomas)
01/2015 - 01/2002
13Pituitary Neoplasms (Pituitary Adenoma)
01/2015 - 05/2002
11Papillary Carcinoma
04/2011 - 01/2002
6Neoplasm Metastasis (Metastasis)
01/2015 - 05/2011
5Adenocarcinoma
01/2014 - 01/2003
5Breast Neoplasms (Breast Cancer)
05/2006 - 10/2002
4Neoplastic Cell Transformation
05/2014 - 12/2007
3Colonic Neoplasms (Colon Cancer)
01/2015 - 10/2002
3Seminoma
12/2012 - 03/2005
3Prolactinoma (Prolactinomas)
09/2010 - 12/2005
3Hyperplasia
01/2007 - 01/2002
3Multiple Endocrine Neoplasia Type 2b (MEN 3)
08/2004 - 06/2002
2Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
12/2012 - 03/2005
2Glucose Intolerance
09/2012 - 01/2009
2Goiter
09/2012 - 10/2003
2Pancreatic Neoplasms (Pancreatic Cancer)
02/2012 - 11/2004
2Insulin Resistance
01/2009 - 07/2005
2Multiple Endocrine Neoplasia Type 2a (MEN 2)
06/2006 - 08/2004
2Glioma (Gliomas)
12/2004 - 07/2004
2Infection
11/2004 - 05/2002
1Lung Neoplasms (Lung Cancer)
11/2015
1Ataxia (Dyssynergia)
01/2013
1Hyperglycemia
09/2012
1Hypersensitivity (Allergy)
09/2012
1Growth Hormone-Secreting Pituitary Adenoma
07/2012
1Vascular System Injuries
02/2012

Drug/Important Bio-Agent (IBA)

25Factor IX (PTC)FDA LinkGeneric
05/2015 - 01/2002
24Proteins (Proteins, Gene)IBA
01/2015 - 05/2002
19MicroRNAs (MicroRNA)IBA
01/2015 - 09/2007
17HMGA ProteinsIBA
01/2015 - 01/2003
14Phosphotransferases (Kinase)IBA
04/2015 - 02/2002
10Messenger RNA (mRNA)IBA
08/2015 - 04/2003
9ProlactinIBA
01/2015 - 05/2002
8anaplastic Thyroid cancerIBA
12/2011 - 06/2002
8papillary Thyroid cancerIBA
12/2010 - 01/2002
7Growth Hormone (Somatotropin)IBA
01/2015 - 05/2002
5Cadherins (E-Cadherin)IBA
02/2015 - 06/2005
5Transcription Factors (Transcription Factor)IBA
03/2013 - 05/2003
5HMGA2 ProteinIBA
07/2012 - 11/2003
4RNA (Ribonucleic Acid)IBA
05/2015 - 06/2002
4Protein Tyrosine PhosphatasesIBA
01/2013 - 07/2004
4Insulin ReceptorIBA
09/2012 - 07/2005
4Cyclin-Dependent Kinase Inhibitor p27IBA
09/2007 - 10/2002
3DNA (Deoxyribonucleic Acid)IBA
01/2014 - 04/2005
3Insulin (Novolin)FDA Link
09/2012 - 01/2009
3HormonesIBA
01/2012 - 05/2002
3Class 3 Receptor-Like Protein Tyrosine PhosphatasesIBA
12/2010 - 02/2003
3CyclinsIBA
06/2010 - 08/2004
3ONYX015 (ONYX-015)IBA
11/2007 - 06/2002
3Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
05/2007 - 07/2004
3tyrosine receptor (receptor, tyrosine)IBA
06/2006 - 02/2002
31-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride (DEP)IBA
11/2004 - 07/2004
3Complementary DNA (cDNA)IBA
11/2004 - 05/2002
2Nuclear Proteins (Protein, Nuclear)IBA
07/2015 - 05/2006
2OsteopontinIBA
02/2015 - 01/2015
2cetuximab (Erbitux)FDA Link
01/2015 - 01/2014
2Epidermal Growth Factor Receptor (EGF Receptor)IBA
01/2014 - 12/2002
2PeptidesIBA
07/2013 - 10/2012
2Carbon MonoxideIBA
12/2012 - 05/2011
2Estrogens (Estrogen)FDA Link
12/2012 - 11/2004
2Tyrosine (L-Tyrosine)FDA Link
10/2012 - 12/2010
2Glucose (Dextrose)FDA LinkGeneric
09/2012 - 01/2009
2Chemokine CXCL12IBA
09/2011 - 08/2004
2Somatostatin Receptors (Somatostatin Receptor)IBA
05/2007 - 07/2004
2RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
12/2005 - 06/2002
2PTEN Phosphohydrolase (PTEN Phosphatase)IBA
11/2005 - 03/2005
2PPAR gammaIBA
08/2004 - 10/2002
2ThymosinIBA
08/2004 - 09/2002
2N- (4- bromo- 2- fluorophenyl)- 6- methoxy- 7- ((1- methylpiperidin- 4- yl)methoxy)quinazolin- 4- amine (ZD6474)IBA
06/2004 - 12/2002
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
12/2002 - 06/2002
2Oncogene Proteins (Oncogene Protein)IBA
12/2002 - 06/2002
1Etoposide (VP 16)FDA LinkGeneric
11/2015
1irinotecan (Camptosar)FDA LinkGeneric
11/2015
1Ovarian epithelial cancerIBA
08/2015
1Cyclin B1IBA
01/2015
1leucine-rich repeat proteinsIBA
01/2015
1Biological Markers (Surrogate Marker)IBA
01/2015
13',5'-Cyclic-AMP Phosphodiesterases (3',5' Cyclic Nucleotide Phosphodiesterase)IBA
07/2014
1PolyphosphatesIBA
07/2014
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
07/2014
1Antineoplastic Agents (Antineoplastics)IBA
01/2014
1gemcitabineFDA Link
01/2014
1ataxia telangiectasia mutated proteinIBA
01/2014
1Histone Deacetylase InhibitorsIBA
06/2013
1Ubiquitin-Conjugating EnzymesIBA
03/2013
1trabectedin (ecteinascidin 743)IBA
03/2013
1UbiquitinIBA
03/2013
1Proteasome Endopeptidase Complex (Proteasome)IBA
03/2013
1Glycoproteins (Glycoprotein)IBA
11/2012
1Cyclin EIBA
05/2012
1Matrix Metalloproteinase 9 (Gelatinase B)IBA
02/2012
1CXCR4 Receptors (CXCR4 Receptor)IBA
09/2011
1Serine (L-Serine)FDA Link
08/2011

Therapy/Procedure

6Heterologous Transplantation (Xenotransplantation)
11/2007 - 06/2002
2Drug Therapy (Chemotherapy)
02/2010 - 09/2004
2Lasers (Laser)
06/2006 - 06/2002
2Investigational Therapies (Experimental Therapy)
10/2002 - 06/2002