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Tohru Funahashi Selected Research

Adiponectin

05/2008Adiponectin protects against angiotensin II-induced cardiac fibrosis through activation of PPAR-alpha.
04/2008Prognostic value of adiponectin for cardiovascular disease and mortality.
04/2008Nocturnal reduction in circulating adiponectin concentrations related to hypoxic stress in severe obstructive sleep apnea-hypopnea syndrome.
02/2008Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis.
01/2008Association of adiponectin and resistin with cardiovascular events in Korean patients with type 2 diabetes: The Korean atherosclerosis study (KAS) A 42-month prospective study.
01/2008Clinical significance of high-molecular weight form of adiponectin in male patients with coronary artery disease.
10/2007Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired glucose tolerance and coronary artery disease.
09/2007Future adverse cardiac events can be predicted by persistently low plasma adiponectin concentrations in men and marked reductions of adiponectin in women after acute myocardial infarction.
09/2007Exacerbation of albuminuria and renal fibrosis in subtotal renal ablation model of adiponectin-knockout mice.
07/2007A novel index of insulin resistance determined from the homeostasis model assessment index and adiponectin levels in Japanese subjects.
04/2007The genes influencing adiponectin levels also influence risk factors for metabolic syndrome and type 2 diabetes.
12/2006Adiponectin and renal function, and implication as a risk of cardiovascular disease.
10/2006Adiponectin and inflammatory markers in peripheral arterial occlusive disease.
09/2006Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease.
09/2006Effect of adiponectin on murine colitis induced by dextran sulfate sodium.
06/2006Adiponectin replenishment ameliorates obesity-related hypertension.
03/2006Adiponectin: a key adipocytokine in metabolic syndrome.
12/2005Inverse relationship between plasminogen activator inhibitor-I activity and adiponectin in overweight and obese women. Interrelationship with visceral adipose tissue, insulin resistance, HDL-chol and inflammation.
10/2005Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms.
09/2005Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism.
07/2005Resting metabolic rate is an important predictor of serum adiponectin concentrations: potential implications for obesity-related disorders.
04/2005High serum adiponectin levels during steroid-responsive nephrotic syndrome relapse.
01/2005Levels of the adipocyte-derived plasma protein, adiponectin, have a close relationship with atheroma.
01/2005Adiponectin in chronic kidney disease is related more to metabolic disturbances than to decline in renal function.
01/2005Reciprocal association of plasma adiponectin and serum C-reactive protein concentration in haemodialysis patients with end-stage kidney disease--a follow-up study.
11/2004Adiponectin as a biomarker of the metabolic syndrome.
07/2004Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling.
07/2004Plasma adiponectin, insulin sensitivity, and subclinical inflammation in women with prior gestational diabetes mellitus.
04/2004Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease.
01/2004Adiponectin and metabolic syndrome.
12/2003Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin.
12/2003Obesity, adiponectin and vascular inflammatory disease.
11/2003Association of serum adiponectin levels with breast cancer risk.
08/2003A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin.
06/2003Disturbed secretion of mutant adiponectin associated with the metabolic syndrome.
05/2003Adiponectin is markedly increased in patients with nephrotic syndrome and is related to metabolic risk factors.
04/2003Circulating concentration of adiponectin and its expression in subcutaneous adipose tissue in patients with highly active antiretroviral therapy-associated lipodystrophy.
01/2003Decreased plasma adiponectin concentration in patients with essential hypertension.
11/2002Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice.
11/2002Plasma adiponectin levels in overweight and obese Asians.
10/2002Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis.
10/2002Low plasma adiponectin concentrations do not predict weight gain in humans.
10/2002Plasma adiponectin concentrations in children: relationships with obesity and insulinemia.
09/2002Adiponectin in essential hypertension.
07/2002Diet-induced insulin resistance in mice lacking adiponectin/ACRP30.
07/2002[Adiponectin as a key molecule of the metabolic syndrome]
07/2002Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome.
01/2002Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease.

Articles by Research Topic

Disease

11Syndrome
04/2008 - 07/2002
8Obesity
03/2007 - 04/2002
6Coronary Artery Disease (Coronary Atherosclerosis)
01/2008 - 04/2002
5Atherosclerosis (Atheroma)
02/2008 - 11/2002
4Insulin Resistance
07/2007 - 07/2002
4Hypertension (High Blood Pressure)
06/2006 - 09/2002
3Lipodystrophy
06/2004 - 04/2003
2Fibrosis (Cirrhosis)
05/2008 - 09/2007
2Cardiovascular Diseases (Cardiovascular Disease)
04/2008 - 12/2006
2Breast Neoplasms (Breast Cancer)
03/2006 - 11/2003
2Overweight
12/2005 - 11/2002
2Nephrotic Syndrome (Syndrome, Nephrotic)
04/2005 - 05/2003
2Chronic Kidney Failure (Chronic Renal Failure)
01/2005 - 01/2002
1Obstructive Sleep Apnea
04/2008
1Albuminuria
09/2007
1Myocardial Infarction
09/2007
1Anoxia (Hypoxia)
10/2006
1Arterial Occlusive Diseases (Arterial Occlusive Disease)
10/2006
1Colitis
09/2006
1Reperfusion Injury
10/2005
1Myocardial Ischemia (Ischemic Heart Diseases)
10/2005
1Heart Failure
09/2005
1Kidney Diseases (Kidney Disease)
01/2005
1Ischemia
07/2004
1Inflammation
07/2004
1Gestational Diabetes (Gestational Diabetes Mellitus)
07/2004
1Arteriosclerosis
03/2004
1Liver Cirrhosis (Hepatic Cirrhosis)
12/2003
1Cushing Syndrome
10/2003
1Carcinoid Tumor (Carcinoid)
10/2003
1Pathologic Constriction (Stenosis)
10/2002
1Weight Gain
10/2002

Drug/Important Bio-Agent (IBA)

48AdiponectinIBA
05/2008 - 01/2002
3Glucose (Dextrose)FDA LinkGeneric
11/2007 - 09/2005
2Insulin (Novolin)FDA Link
03/2008 - 07/2004
2C-Reactive ProteinIBA
01/2005 - 03/2004
2AdipokinesIBA
07/2003 - 01/2003
1Angiotensin IIIBA
05/2008
1PPAR alphaIBA
05/2008
1LigandsIBA
02/2008
1ResistinIBA
01/2008
1Pravastatin (Pravachol)FDA LinkGeneric
10/2007
1secretogranin IIIIBA
03/2007
1NeuropeptidesIBA
03/2007
1Nicotinamide PhosphoribosyltransferaseIBA
10/2006
1Dextran SulfateIBA
09/2006
1Leptin ReceptorsIBA
03/2006
1Messenger RNA (mRNA)IBA
03/2006
1LeptinIBA
03/2006
1Plasminogen Activators (Plasminogen Activator)IBA
12/2005
1Glycerol KinaseIBA
08/2005
1pioglitazone (Actos)FDA Link
07/2005
1rosiglitazone (Avandia)FDA Link
06/2004
1Carbon Tetrachloride (Tetrachloromethane)IBA
12/2003
1Adrenocorticotropic Hormone (ACTH)FDA Link
10/2003
1ApolipoproteinsIBA
11/2002
1HormonesIBA
11/2002
1heparin-binding EGF-like growth factor (HB-EGF)IBA
04/2002

Therapy/Procedure

2Highly Active Antiretroviral Therapy (HAART)
06/2004 - 04/2003