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Masakazu Fukushima Selected Research

Fluorouracil (Carac)

8/2012Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells.
9/2011Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination.
11/2010Comparative proteomic analysis of the ribosomes in 5-fluorouracil resistance of a human colon cancer cell line using the radical-free and highly reducing method of two-dimensional polyacrylamide gel electrophoresis.
8/2010Gimeracil sensitizes cells to radiation via inhibition of homologous recombination.
2/2009The role of dihydropyrimidine dehydrogenase expression in resistance to 5-fluorouracil in head and neck squamous cell carcinoma cells.
1/2009Correlations between thymidylate synthase expression and chemosensitivity to 5-fluorouracil, cell proliferation and clinical outcome in head and neck squamous cell carcinoma.
9/2008Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-fluorouracil.
1/2008Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity.
7/2007Expression of orotate phosphoribosyl transferase in human pancreatic cancer: implication for the efficacy of uracil and tegafur-based adjuvant chemotherapy.
6/2007Therapeutic potential of the dual-targeted TAS-102 formulation in the treatment of gastrointestinal malignancies.
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Masakazu Fukushima Research Topics

Disease

47Neoplasms (Cancer)
09/2011 - 01/2002
7Colorectal Neoplasms (Colorectal Cancer)
08/2012 - 07/2003
7Carcinoma (Carcinomatosis)
09/2008 - 04/2002
5Colonic Neoplasms (Colon Cancer)
08/2012 - 03/2005
5Breast Neoplasms (Breast Cancer)
09/2008 - 01/2002
4Neoplasm Metastasis (Metastasis)
12/2004 - 01/2002
3Lung Neoplasms (Lung Cancer)
05/2009 - 03/2005
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
02/2009 - 09/2008
3Fibrosarcoma
10/2007 - 01/2002
3Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/2006 - 02/2004
3Renal Cell Carcinoma (Grawitz Tumor)
02/2004 - 04/2003
2Infection
11/2010 - 01/2007
2Pancreatic Neoplasms (Pancreatic Cancer)
07/2007 - 09/2004
2Stomach Neoplasms (Stomach Cancer)
12/2006 - 08/2006
2Adenocarcinoma
05/2003 - 02/2002
1Hypersensitivity (Allergy)
09/2008
1Prostatic Neoplasms (Prostate Cancer)
05/2007
1Cachexia
12/2006
1Body Weight (Weight, Body)
12/2006
1Esophageal Neoplasms (Esophageal Cancer)
09/2004
1Residual Neoplasm
04/2004
1Mucinous Adenocarcinoma (Mucinous Carcinoma)
05/2003
1Ovarian Neoplasms (Ovarian Cancer)
05/2003

Drug/Important Bio-Agent (IBA)

29Fluorouracil (Carac)FDA LinkGeneric
08/2012 - 01/2002
14Thymidylate SynthaseIBA
01/2009 - 01/2002
9Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA
08/2010 - 01/2002
7DNA (Deoxyribonucleic Acid)IBA
01/2011 - 04/2004
61- (3- C- ethynylribopentofuranosyl)cytosineIBA
05/2009 - 01/2002
5EnzymesIBA
12/2006 - 01/2002
5Thymidine PhosphorylaseIBA
07/2005 - 12/2002
4NucleosidesIBA
10/2007 - 04/2002
4TegafurIBA
07/2007 - 07/2005
4UracilIBA
07/2007 - 07/2005
3Cisplatin (Platino)FDA LinkGeneric
05/2009 - 04/2006
3Messenger RNA (mRNA)IBA
09/2008 - 07/2002
3Folic Acid (Vitamin M)FDA LinkGeneric
01/2008 - 01/2006
3TransferasesIBA
07/2007 - 05/2005
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
07/2007 - 12/2002
3capecitabine (Xeloda)FDA Link
04/2007 - 12/2004
3TaxoidsIBA
12/2004 - 01/2002
3ProdrugsIBA
12/2004 - 12/2002
3Paclitaxel (Taxol)FDA LinkGeneric
12/2004 - 01/2002
2gimeracilIBA
09/2011 - 08/2010
2pppA(2'p5'A)n-dependent ribonuclease (RNase L)IBA
11/2010 - 01/2007
2Proteins (Proteins, Gene)IBA
11/2010 - 05/2005
2PlatinumIBA
09/2008 - 06/2007
2Leucovorin (Folinic Acid)FDA Link
01/2008 - 03/2007
2gemcitabineFDA Link
07/2007 - 04/2006
2CytotoxinsIBA
06/2007 - 09/2003
2titanium silicide (TS-1)IBA
03/2007 - 09/2004
2Orotate PhosphoribosyltransferaseIBA
12/2006 - 02/2004
2docetaxel (Taxotere)FDA Link
08/2006 - 06/2006
2Biological Markers (Surrogate Marker)IBA
04/2006 - 09/2003
2Trifluridine (Viroptic)FDA LinkGeneric
01/2006 - 03/2005
2doxifluridineIBA
07/2005 - 01/2002
2TAS 102IBA
09/2004 - 04/2004
1MicroRNAs (MicroRNA)IBA
08/2012
1RNA Polymerase I (Polymerase I, RNA)IBA
11/2010
1Ribonucleases (Ribonuclease)IBA
11/2010
1GTP Phosphohydrolases (GTPases)IBA
11/2010
1ProteomeIBA
11/2010
1polyacrylamideIBA
11/2010
1DNA-Directed RNA Polymerases (RNA Polymerase)IBA
05/2009
1CytosineIBA
04/2009
1irinotecan (Camptosar)FDA LinkGeneric
06/2007
1AntimetabolitesIBA
06/2007
1oxaliplatin (Eloxatin)FDA LinkGeneric
06/2007
1Leukemia Inhibitory FactorIBA
12/2006
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
12/2006
1Interleukin-6 (Interleukin 6)IBA
12/2006
1Dihydrouracil Dehydrogenase (NAD+)IBA
06/2006
1Epidermal Growth Factor Receptor (EGF Receptor)IBA
04/2006
1Carboplatin (JM8)FDA LinkGeneric
04/2006
1erlotinib (CP 358,774)FDA Link
04/2006
1gefitinib (Iressa)FDA Link
04/2006
1Ribonucleotide Reductases (Ribonucleotide Reductase)IBA
04/2006
1Folic Acid AntagonistsIBA
01/2006
1Drug CombinationsIBA
01/2006
1potassium oxonateIBA
07/2005
1PyrimidinesIBA
07/2005
1PeptidesIBA
05/2005
1IonomycinIBA
02/2005
1phorbolIBA
02/2005
1Transcription Factor AP-1 (Transcription Factor AP 1)IBA
02/2005
1taxaneIBA
12/2004
1Progesterone Receptors (Progesterone Receptor)IBA
05/2004
1OxidoreductasesIBA
05/2004
1Estrogens (Estrogen)FDA Link
05/2004
1Angiogenesis Inducing Agents (Angiogenesis Factor)IBA
04/2004
1Proliferating Cell Nuclear Antigen (PCNA)IBA
02/2004
1AntigensIBA
02/2004
1pyrimidineIBA
09/2003
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2003
1InterferonsIBA
12/2002

Therapy/Procedure

12Drug Therapy (Chemotherapy)
02/2009 - 09/2003
11Heterologous Transplantation (Xenotransplantation)
05/2009 - 12/2002
3Adjuvant Chemotherapy
07/2007 - 12/2006
1Radiotherapy
01/2011
1Prostatectomy (Retropubic Prostatectomy)
05/2007
1Combination Drug Therapy (Combination Chemotherapy)
08/2006