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Masakazu Fukushima Selected Research

Fluorouracil (Carac)

8/2012Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells.
9/2011Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination.
5/2011In vivo evidence for a significant role of folylpolyglutamate synthase in combined chemotherapy with oral fluoropyrimidine, UFT or S-1, and leucovorin.
11/2010Gimeracil, a component of S-1, may enhance the antitumor activity of X-ray irradiation in human cancer xenograft models in vivo.
11/2010Comparative proteomic analysis of the ribosomes in 5-fluorouracil resistance of a human colon cancer cell line using the radical-free and highly reducing method of two-dimensional polyacrylamide gel electrophoresis.
10/2010Irinotecan overcomes the resistance to 5-fluorouracil in human colon cancer xenografts by down-regulation of intratumoral thymidylate synthase.
8/2010Gimeracil sensitizes cells to radiation via inhibition of homologous recombination.
6/2010Rapamycin enhances chemotherapy-induced cytotoxicity by inhibiting the expressions of TS and ERK in gastric cancer cells.
5/2010Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells.
1/2010UFT and S-1 for treatment of primary lung cancer.
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Masakazu Fukushima Research Topics

Disease

86Neoplasms (Cancer)
05/2012 - 01/2002
15Colonic Neoplasms (Colon Cancer)
08/2012 - 08/2002
15Carcinoma (Carcinomatosis)
06/2010 - 04/2002
14Colorectal Neoplasms (Colorectal Cancer)
08/2012 - 08/2002
11Stomach Neoplasms (Stomach Cancer)
06/2010 - 12/2002
8Breast Neoplasms (Breast Cancer)
09/2008 - 01/2002
5Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
06/2014 - 02/2004
5Pancreatic Neoplasms (Pancreatic Cancer)
04/2010 - 09/2004
5Lung Neoplasms (Lung Cancer)
01/2010 - 12/2003
4Squamous Cell Carcinoma (Epidermoid Carcinoma)
02/2009 - 01/2007
4Adenocarcinoma
10/2006 - 02/2002
4Neoplasm Metastasis (Metastasis)
12/2004 - 01/2002
4Renal Cell Carcinoma (Grawitz Tumor)
02/2004 - 02/2003
3Fibrosarcoma
10/2007 - 01/2002
2Gastrointestinal Neoplasms (Gastrointestinal Cancer)
11/2010 - 08/2005
2Infection
11/2010 - 01/2007
2Body Weight (Weight, Body)
12/2006 - 08/2005
1Disease Progression
11/2010
1Head and Neck Neoplasms (Head and Neck Cancer)
11/2010
1Necrosis
05/2010
1Hypersensitivity (Allergy)
09/2008
1Lewis Lung Carcinoma
08/2007
1Prostatic Neoplasms (Prostate Cancer)
05/2007

Drug/Important Bio-Agent (IBA)

60Fluorouracil (Carac)FDA LinkGeneric
08/2012 - 01/2002
24Thymidylate SynthaseIBA
06/2014 - 01/2002
16Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA
08/2010 - 01/2002
11Messenger RNA (mRNA)IBA
05/2011 - 07/2002
10DNA (Deoxyribonucleic Acid)IBA
01/2011 - 04/2004
10Orotate PhosphoribosyltransferaseIBA
12/2008 - 02/2004
8Thymidine PhosphorylaseIBA
05/2012 - 12/2002
8TegafurIBA
10/2010 - 07/2005
8EnzymesIBA
10/2010 - 01/2002
7Trifluridine (Viroptic)FDA LinkGeneric
06/2014 - 03/2005
71- (3- C- ethynylribopentofuranosyl)cytosineIBA
05/2009 - 01/2002
6Paclitaxel (Taxol)FDA LinkGeneric
12/2008 - 01/2002
6TAS 102IBA
10/2008 - 04/2004
6capecitabine (Xeloda)FDA Link
08/2008 - 12/2004
6UracilIBA
07/2007 - 07/2005
5gimeracilIBA
09/2011 - 06/2006
5Proteins (Proteins, Gene)IBA
11/2010 - 05/2005
5Cisplatin (Platino)FDA LinkGeneric
11/2010 - 04/2006
5irinotecan (Camptosar)FDA LinkGeneric
10/2010 - 06/2006
4Folic Acid (Vitamin M)FDA LinkGeneric
05/2011 - 01/2006
4ProdrugsIBA
10/2010 - 12/2002
4docetaxel (Taxotere)FDA Link
06/2010 - 06/2006
4NucleosidesIBA
10/2007 - 04/2002
4TransferasesIBA
07/2007 - 05/2005
4TaxoidsIBA
06/2006 - 01/2002
3Leucovorin (Folinic Acid)FDA Link
05/2011 - 03/2007
3pppA(2'p5'A)n-dependent ribonuclease (RNase L)IBA
11/2010 - 01/2006
3Ribonucleotide Reductases (Ribonucleotide Reductase)IBA
10/2010 - 04/2006
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
07/2007 - 12/2002
3gemcitabineFDA Link
07/2007 - 05/2005
3titanium silicide (TS-1)IBA
03/2007 - 09/2004
3Biological Markers (Surrogate Marker)IBA
01/2007 - 09/2003
3Thymidine KinaseIBA
01/2007 - 11/2002
3doxifluridineIBA
06/2006 - 01/2002
2ThymidineIBA
05/2012 - 10/2008
2polyacrylamideIBA
11/2010 - 08/2008
2oxaliplatin (Eloxatin)FDA LinkGeneric
10/2010 - 06/2007
2Oxonic AcidIBA
10/2010 - 06/2006
2erlotinib (CP 358,774)FDA Link
02/2010 - 04/2006
2Epidermal Growth Factor Receptor (EGF Receptor)IBA
02/2010 - 04/2006
2Thrombospondin 1IBA
10/2008 - 08/2008
2PlatinumIBA
09/2008 - 06/2007
2potassium oxonateIBA
08/2008 - 07/2005
2CytotoxinsIBA
06/2007 - 09/2003
2pyrimidineIBA
01/2007 - 09/2003
2Uridine PhosphorylaseIBA
01/2007 - 12/2002
2Carbon MonoxideIBA
10/2006 - 08/2005
2PeptidesIBA
08/2005 - 05/2005
2RNA (Ribonucleic Acid)IBA
01/2005 - 01/2002
1MicroRNAs (MicroRNA)IBA
08/2012
1ThymineIBA
05/2012
1folylpolyglutamate synthetaseIBA
05/2011
1Small Interfering RNA (siRNA)IBA
05/2011
1Ribonucleases (Ribonuclease)IBA
11/2010
1RNA Polymerase I (Polymerase I, RNA)IBA
11/2010
1Staphylococcal Protein A (A, Protein)IBA
11/2010
1ProteomeIBA
11/2010
1GTP Phosphohydrolases (GTPases)IBA
11/2010
1PotassiumIBA
10/2010
1Sirolimus (Rapamycin)FDA Link
06/2010
1CaspasesIBA
05/2010
1CholesterolIBA
04/2010
1oxysterol receptorIBA
04/2010
1tensins (tensin)IBA
04/2010
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
02/2010
1DNA-Directed RNA Polymerases (RNA Polymerase)IBA
05/2009
1CytosineIBA
04/2009
1harpin (messenger)IBA
11/2007
1AntimetabolitesIBA
06/2007
1Type I DNA Topoisomerases (Topoisomerase I)IBA
01/2007
1AdenosineFDA LinkGeneric
01/2007

Therapy/Procedure

26Drug Therapy (Chemotherapy)
05/2011 - 02/2003
26Heterologous Transplantation (Xenotransplantation)
11/2010 - 12/2002
4Oral Administration
10/2008 - 08/2005
4Adjuvant Chemotherapy
08/2007 - 12/2006
3Radiotherapy
05/2012 - 11/2010
1Prostatectomy (Retropubic Prostatectomy)
05/2007