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Mark A Frye Selected Research

modafinil (armodafinil)

12/2015Randomized, placebo-controlled, adjunctive study of armodafinil for bipolar I depression: implications of novel drug design and heterogeneity of concurrent bipolar maintenance treatments.
8/2015Adjunctive armodafinil for major depressive episodes associated with bipolar I disorder.
12/2014Balancing benefits and harms of treatments for acute bipolar depression.
10/2014Efficacy and safety of adjunctive armodafinil in adults with major depressive episodes associated with bipolar I disorder: a randomized, double-blind, placebo-controlled, multicenter trial.
10/2010Adjunctive armodafinil for major depressive episodes associated with bipolar I disorder: a randomized, multicenter, double-blind, placebo-controlled, proof-of-concept study.
3/2010Modafinil for bipolar depression with comorbid methamphetamine abuse.
8/2007A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression.

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Mark A Frye Research Topics

Disease

57Bipolar Disorder (Mania)
12/2015 - 02/2002
5Mood Disorders (Mood Disorder)
11/2014 - 02/2002
4Nausea
12/2015 - 10/2014
4Obesity
12/2015 - 03/2002
4Parkinson Disease (Parkinson's Disease)
09/2014 - 07/2011
3Sleep Initiation and Maintenance Disorders (Insomnia)
12/2015 - 10/2010
3Headache (Headaches)
12/2015 - 10/2010
3Weight Gain
12/2015 - 06/2007
3Movement Disorders (Movement Disorder)
12/2015 - 06/2009
3Diarrhea
08/2015 - 10/2010
3Overweight
06/2007 - 10/2003
2Exanthema (Rash)
12/2015 - 11/2002
2Psychomotor Agitation (Akathisia)
12/2014 - 08/2007
2Mental Disorders (Mental Disorder)
01/2014 - 11/2011
2Tourette Syndrome (Tourette's Syndrome)
12/2013 - 06/2009
2Substance-Related Disorders (Drug Abuse)
01/2013 - 11/2011
2Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
01/2013 - 06/2009
2Alcoholism (Alcohol Abuse)
11/2011 - 12/2006
2Weight Loss (Weight Reduction)
06/2007 - 12/2006
1Necrosis
10/2015
1Encephalitis (Encephalitis, Rasmussen)
05/2015
1Hepatitis
10/2014
1Liver Failure
10/2014
1Bulimia (Binge Eating)
08/2014
1Mental Retardation (Idiocy)
05/2012
1Vomiting
05/2012
1Lethargy
05/2012
1Inborn Urea Cycle Disorders
05/2012
1Coma (Comas)
05/2012
1Eating Disorders (Eating Disorder)
02/2011
1Fatigue
08/2007
1Hyperandrogenism
12/2005
1Oligomenorrhea
12/2005
1Insulin Resistance
06/2005
1Body Weight (Weight, Body)
05/2005
1Epilepsy (Aura)
03/2005
1Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
08/2004

Drug/Important Bio-Agent (IBA)

10Antidepressive Agents (Antidepressants)IBA
12/2014 - 07/2003
9lamotrigine (Lamictal)FDA LinkGeneric
06/2015 - 02/2002
8Carbon MonoxideIBA
09/2014 - 12/2005
7modafinil (armodafinil)FDA Link
12/2015 - 08/2007
7LithiumIBA
12/2014 - 02/2002
5Antipsychotic Agents (Antipsychotics)IBA
05/2012 - 10/2003
5Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
05/2012 - 08/2004
4quetiapine (Seroquel)FDA Link
12/2014 - 11/2007
4Anticonvulsants (Antiepileptic Drugs)IBA
05/2012 - 05/2002
3aripiprazole (Abilify)FDA Link
05/2012 - 08/2007
2Biological Markers (Surrogate Marker)IBA
12/2015 - 04/2013
2N-acetylaspartate (N-acetyl aspartate)IBA
06/2015 - 04/2007
2Protons (Proton)IBA
06/2015 - 04/2007
2N-Methylaspartate (NMDA)IBA
05/2015 - 01/2007
2Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA
02/2015 - 01/2012
2N- (2- (4- (1,2- benzisothiazol- 3- yl)- 1- piperazinylmethyl)- 1- cyclohexylmethyl)- 2,3- bicyclo(2.2.1)heptanedicarboximideIBA
12/2014 - 12/2014
2olanzapine-fluoxetine combination (Symbyax)FDA Link
12/2014 - 12/2014
2Glutamic Acid (Glutamate)FDA Link
12/2007 - 01/2007
2CreatineIBA
12/2007 - 04/2007
2topiramate (Topamax)FDA LinkGeneric
06/2007 - 12/2006
2sibutramine (Meridia)FDA Link
06/2007 - 12/2006
2zonisamide (Zonegran)FDA LinkGeneric
12/2006 - 05/2005
2AntibodiesIBA
10/2003 - 02/2002
1NicotineFDA Link
12/2015
1Excipients (Suspending Agents)IBA
12/2015
1C-Reactive ProteinIBA
10/2015
1Interleukin-6 (Interleukin 6)IBA
10/2015
1DNA (Deoxyribonucleic Acid)IBA
09/2015
1Brain-Derived Neurotrophic Factor (BDNF)IBA
09/2015
1N-acetyl-1-aspartylglutamic acid (NAAGA)IBA
06/2015
1Immunoglobulin G (IgG)IBA
05/2015
1Apolipoproteins B (ApoB)IBA
08/2014
1Thyroid HormonesIBA
02/2014
1Thyroxine (Levothyroxine)FDA LinkGeneric
02/2014
1Hypnotics and Sedatives (Sedatives)IBA
01/2014
1Levodopa (L Dopa)FDA LinkGeneric
11/2013
1CalciumIBA
04/2013
1Risperidone (Risperdal Consta)FDA LinkGeneric
05/2012
1olanzapine (Zyprexa)FDA Link
05/2012
1Carnitine (L-Carnitine)FDA LinkGeneric
05/2012
1ziprasidone (Geodon)FDA Link
05/2012
1Trazodone (Trittico)FDA LinkGeneric
11/2011
1Methamphetamine (Desoxyn)FDA LinkGeneric
03/2010
1Glycine (Aminoacetic Acid)FDA LinkGeneric
01/2007
1Aspartic Acid (Aspartate)FDA Link
01/2007
1Excitatory Amino AcidsIBA
01/2007
1Carbamazepine (Tegretol)FDA LinkGeneric
12/2006
1Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA
11/2006
1Bupropion (Wellbutrin)FDA LinkGeneric
02/2006
1Sertraline (Zoloft)FDA LinkGeneric
02/2006
1venlafaxine (Effexor)FDA LinkGeneric
02/2006
1Testosterone (Sustanon)FDA Link
06/2005
1Contraceptive Agents (Contraceptives)IBA
06/2005
1HormonesIBA
06/2005
1etiracetam (levetiracetam)FDA LinkGeneric
03/2005
1SASIBA
11/2004
1SodiumIBA
08/2004

Therapy/Procedure

8Deep Brain Stimulation
09/2014 - 06/2009
3Drug Therapy (Chemotherapy)
09/2009 - 05/2007
2Therapeutics
12/2015 - 05/2015
1Individualized Medicine
09/2015
1Bariatric Surgery
11/2014
1Electrodes (Electrode)
01/2012