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Cheryl A Frye Selected Research

Progestins (Progestagens)

1/2011Effects and Mechanisms of 3α,5α,-THP on Emotion, Motivation, and Reward Functions Involving Pregnane Xenobiotic Receptor.
1/2011Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review.
7/2010Effects and mechanisms of progestogens and androgens in ictal activity.
11/2009Estrogen increases latencies to seizures and levels of 5alpha-pregnan-3alpha-ol-20-one in hippocampus of wild-type, but not 5alpha-reductase knockout, mice.
10/2008Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways.
9/2008Activity of protein kinase C is important for 3alpha,5alpha-THP's actions at dopamine type 1-like and/or GABAA receptors in the ventral tegmental area for lordosis of rats.
9/2008In the ventral tegmental area, progestogens' membrane-mediated actions for lordosis of rats involve the second-messenger phospholipase C.
1/2008Effects of progesterone administration and APPswe+PSEN1Deltae9 mutation for cognitive performance of mid-aged mice.
1/2008Hormonal influences on seizures: basic neurobiology.
9/2006Progestins' effects on sexual behaviour of female rats and hamsters involving D1 and GABA(A) receptors in the ventral tegmental area may be G-protein-dependent.
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Cheryl A Frye Research Topics

Disease

35Lordosis
07/2014 - 08/2002
16Seizures (Seizure)
07/2014 - 03/2003
10Epilepsy (Aura)
07/2014 - 03/2004
3Neoplasms (Cancer)
03/2011 - 04/2009
3Breast Neoplasms (Breast Cancer)
02/2010 - 08/2009
3Alzheimer Disease (Alzheimer's Disease)
06/2009 - 06/2006
3Shock
05/2008 - 07/2003
2Schizophrenia (Dementia Praecox)
01/2011 - 05/2010
2Pain (Aches)
01/2011 - 04/2004
2Substance-Related Disorders (Drug Abuse)
01/2011 - 01/2011
2Partial Epilepsies (Epilepsy, Partial)
11/2006 - 07/2004
1Anxiety Disorders (Anxiety Disorder)
01/2011
1Autistic Disorder (Autism)
06/2010
1Endocrine Gland Neoplasms (Cancer, Endocrine)
02/2010
1Post-Traumatic Stress Disorders (PTSD)
01/2010
1Gambling (Pathological Gambling)
01/2010
1Depressive Disorder (Melancholia)
06/2006
1Dementia (Dementias)
06/2006

Drug/Important Bio-Agent (IBA)

34ProgesteroneFDA LinkGeneric
07/2014 - 01/2003
19Progestins (Progestagens)IBA
01/2011 - 01/2003
12HormonesIBA
07/2014 - 08/2002
12GABA-A Receptors (GABA(A) Receptor)IBA
01/2011 - 01/2003
12Dopamine (Intropin)FDA LinkGeneric
01/2010 - 01/2004
10Estrogens (Estrogen)FDA Link
07/2014 - 04/2004
10Estradiol (Estrace)FDA LinkGeneric
03/2014 - 01/2004
102,3,4,5- Tetrahydro- 7,8- dihydroxy- 1- phenyl- 1H- 3- benzazepine (SKF 38393)IBA
01/2010 - 01/2004
9SteroidsIBA
01/2011 - 03/2004
9gamma-Aminobutyric Acid (GABA)IBA
07/2010 - 03/2003
7Progesterone Receptors (Progesterone Receptor)IBA
03/2014 - 01/2004
6Pregnanolone (Allopregnanolone)IBA
07/2014 - 10/2002
6AndrogensIBA
07/2010 - 03/2004
5GTP-Binding Proteins (G-Protein)IBA
10/2008 - 01/2004
5glutathione-bicarbonate-Ringer solution (BSS plus)FDA LinkGeneric
10/2008 - 01/2006
5MuscimolIBA
09/2008 - 01/2006
4N,N- di- n- hexyl- 2- (4- fluorophenyl)indole- 3- acetamideIBA
01/2014 - 01/2003
4Carbon MonoxideIBA
08/2013 - 01/2008
4BicucullineIBA
01/2011 - 05/2005
4Testosterone (Sustanon)FDA Link
11/2006 - 03/2004
4Pentylenetetrazole (Metrazol)IBA
08/2005 - 12/2004
3Type C PhospholipasesIBA
10/2008 - 09/2008
3Anticonvulsants (Antiepileptic Drugs)IBA
11/2006 - 07/2004
3guanosine 5'-O-(2-thiodiphosphate)IBA
09/2006 - 01/2004
3SCH 23390IBA
06/2005 - 01/2004
2N-Methylaspartate (NMDA)IBA
01/2014 - 02/2007
2PK 11195 (PK11195)IBA
01/2014 - 01/2003
2Steroid Receptors (Steroid Receptor)IBA
01/2011 - 01/2010
2Dizocilpine Maleate (Dizocilpine)IBA
01/2011 - 02/2007
2Fluoxetine (Prozac)FDA LinkGeneric
08/2010 - 12/2003
29,10-Dimethyl-1,2-benzanthracene (DMBA)IBA
09/2009 - 04/2009
2Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
10/2008 - 01/2006
2Adenylate Cyclase (Adenylyl Cyclase)IBA
10/2008 - 08/2006
2estradiol 3-benzoate (estradiol benzoate)IBA
02/2007 - 01/2003
2lamotrigine (Lamictal)FDA LinkGeneric
11/2006 - 07/2004
2AdenosineFDA LinkGeneric
01/2006 - 01/2004
2Sulpiride (neogama)IBA
06/2005 - 07/2004
2QuinpiroleIBA
06/2005 - 07/2004
1Kainic Acid (Kainate)IBA
02/2011
1Vitamin DFDA LinkGeneric
01/2011
1Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
01/2011
1Neurotransmitter Agents (Neurotransmitter)IBA
01/2011
1Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA
05/2010
1alpha-Fetoproteins (AFP)IBA
02/2010
1salicylhydroxamic acid (SHAM)IBA
02/2010
1Oxidopamine (6 Hydroxydopamine)IBA
02/2010
1Antisense OligonucleotidesIBA
01/2010
1Hydrocortisone (Cortisol)FDA LinkGeneric
01/2010
1Oxytocin (Pitocin)FDA LinkGeneric
01/2010
1Oxytocin Receptors (Oxytocin Receptor)IBA
01/2010
1OxidoreductasesIBA
08/2009
1TamoxifenFDA LinkGeneric
08/2009
1trilostaneFDA Link
08/2009
1bisindolylmaleimideIBA
09/2008
1Protein Kinase CIBA
09/2008
11- (6- ((3- methoxyestra- 1,3,5(10)- trien- 17- yl)amino)hexyl)- 1H- pyrrole- 2,5- dioneIBA
09/2008
1LY 235959IBA
09/2008
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
09/2008
1Estrogen Receptor betaIBA
01/2008
1Estrogen Receptor alphaIBA
01/2008
1Protein Isoforms (Isoforms)IBA
01/2008
1Amyloid (Amyloid Fibrils)IBA
01/2008
1Presenilin-1IBA
01/2008
1NMDA receptor A1IBA
02/2007
1maleic acid (maleate)IBA
02/2007
1Phenytoin (Dilantin)FDA LinkGeneric
11/2006
1Carbamazepine (Tegretol)FDA LinkGeneric
11/2006
1Dimethyl Sulfoxide (DMSO)FDA LinkGeneric
09/2006
1bis(p-chlorophenyl)acetic acid (DDA)IBA
08/2006
12- methyl- 4- carboxy- 5- hydroxy- 3,4,5,6- tetrahydropyrimidineIBA
06/2006
1Biological Markers (Surrogate Marker)IBA
06/2006
1protein kinase modulatorIBA
01/2006
1betadex (beta-cyclodextrin)IBA
01/2006
1Dihydrotestosterone (Androstanolone)IBA
09/2005
1CholesterolIBA
09/2005
120-alpha-Dihydroprogesterone (20 alpha-Dihydroprogesterone)IBA
09/2005
1Brain-Derived Neurotrophic Factor (BDNF)IBA
08/2005
1Sesame Oil (Oil, Sesame)IBA
05/2005

Therapy/Procedure

2Therapeutics
07/2010 - 01/2008
1Injections
01/2010
1Intraperitoneal Injections
09/2008
1Ketogenic Diet
09/2005