Isaiah J Fidler Selected Research

Neoplasm Metastasis (Metastasis)

07/2008	Modification of the primary tumor microenvironment by transforming growth factor alpha-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model.
10/2007	Platelet-derived growth factor receptor inhibition and chemotherapy for castration-resistant prostate cancer with bone metastases.
12/2006	Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma.
09/2006	Targeting receptor tyrosine kinase on lymphatic endothelial cells for the therapy of colon cancer lymph node metastasis.
06/2005	Antivascular therapy of human follicular thyroid cancer experimental bone metastasis by blockade of epidermal growth factor receptor and vascular growth factor receptor phosphorylation.
05/2005	Modulation of bone microenvironment with zoledronate enhances the therapeutic effects of STI571 and paclitaxel against experimental bone metastasis of human prostate cancer.
05/2005	Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model.
06/2004	Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice.
12/2003	Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model.
10/2003	Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis.
05/2003	Regression of primary murine colon cancer and occult liver metastasis by intralesional injection of lyophilized preparation of insect cells producing murine interferon-beta.
03/2003	Effects of blocking platelet-derived growth factor-receptor signaling in a mouse model of experimental prostate cancer bone metastases.
03/2003	Active specific immunotherapy against occult brain metastasis.
11/2002	Multiparametric in situ mRNA hybridization analysis of gastric biopsies predicts lymph node metastasis in patients with gastric carcinoma.
10/2002	Inhibition of growth and metastasis of orthotopic human prostate cancer in athymic mice by combination therapy with pegylated interferon-alpha-2b and docetaxel.
08/2002	Specific immunotherapy against occult cancer metastases.
01/2002	Evidence for the causal role of endogenous interferon-alpha/beta in the regulation of angiogenesis, tumorigenicity, and metastasis of cutaneous neoplasms.

Articles by Research Topic

Disease

17	Neoplasms (Cancer) 07/2008 - 01/2002
17	Neoplasm Metastasis (Metastasis) 07/2008 - 01/2002
14	Carcinoma (Carcinomatosis) 08/2007 - 07/2002
10	Prostatic Neoplasms (Prostate Cancer) 10/2007 - 10/2002
6	Colonic Neoplasms (Colon Cancer) 07/2008 - 05/2003
6	Pancreatic Neoplasms (Pancreatic Cancer) 07/2006 - 04/2002
4	Lung Neoplasms (Lung Cancer) 10/2007 - 06/2002
3	Renal Cell Carcinoma (Grawitz Tumor) 06/2006 - 11/2002
3	Mouth Neoplasms (Oral Cancer) 11/2004 - 08/2002
2	Melanoma (Melanoma, Malignant) 01/2008 - 09/2002
1	Thyroid Neoplasms (Thyroid Cancer) 06/2005
1	Breast Neoplasms (Breast Cancer) 01/2005
1	Ovarian Neoplasms (Ovarian Cancer) 04/2004
1	Anoxia (Hypoxia) 04/2004
1	Small Cell Carcinoma 01/2004
1	Hyperplasia 10/2003
1	Osteosarcoma (Osteogenic Sarcoma) 11/2002

Drug/Important Bio-Agent (IBA)

20	Epidermal Growth Factor Receptor (EGF Receptor)IBA 07/2008 - 04/2002
12	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 10/2007 - 03/2003
7	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 05/2008 - 11/2002
5	Paclitaxel (Taxol)FDA LinkGeneric 05/2005 - 07/2002
5	imatinib (Gleevec)FDA Link 05/2005 - 11/2002
4	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 12/2007 - 04/2002
3	Phosphotransferases (Kinase)IBA 05/2008 - 01/2005
3	gemcitabine FDA Link 11/2005 - 05/2003
3	docetaxel (Taxotere)FDA Link 08/2004 - 10/2002
3	Interferon-alpha (Interferon Alfa)FDA Link 05/2003 - 01/2002
2	Transforming Growth Factor alpha (TGF-alpha)IBA 07/2008 - 10/2007
2	Epidermal Growth Factor (EGF)IBA 10/2007 - 07/2005
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2007 - 07/2005
2	Platelet-Derived Growth FactorIBA 04/2004 - 11/2002
2	Messenger RNA (mRNA)IBA 06/2003 - 11/2002
2	Interferon-betaIBA 05/2003 - 07/2002
1	Growth Factor ReceptorsIBA 02/2008
1	Fluconazole (Zonal)FDA LinkGeneric 08/2007
1	tyrosine receptor (receptor, tyrosine)IBA 09/2006
1	trans- 4- (6,7- dimethoxyquinoxalin- 2ylamino)cyclohexanol sulfateIBA 07/2006
1	Interleukin-6 (Interleukin 6)IBA 12/2005
1	Serum Amyloid A Protein (Serum Amyloid A)IBA 11/2005
1	zoledronic acid (zoledronate)FDA Link 05/2005
1	AEE 788 (AEE788)IBA 05/2005
1	Proteins (Proteins, Gene)IBA 02/2005
1	NF-kappa B (NF-kB)IBA 01/2005
1	Interleukin-15 (Interleukin 15)IBA 10/2003
1	Cadherins (E-Cadherin)IBA 06/2003
1	Transforming Growth Factor beta (TGF-beta)IBA 09/2002
1	Immunotoxins (Immunotoxin)IBA 06/2002

Therapy/Procedure

2	Immunotherapy 03/2003 - 08/2002
1	Lymph Node Excision (Lymph Node Dissection) 01/2008
1	Castration 10/2007
1	Drug Therapy (Chemotherapy) 10/2007
1	Prostatectomy (Retropubic Prostatectomy) 06/2003