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I Sadaf Farooqi Selected Research

Obesity

10/2008	Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity.
09/2007	Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.
01/2007	Melanocortin receptors as targets in the treatment of obesity.
12/2006	Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene.
09/2006	Heterozygosity for a POMC-null mutation and increased obesity risk in humans.
08/2005	Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity.
09/2004	Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits.
06/2004	Mutational analysis of the serotonin receptor 5HT2c in severe early-onset human obesity.
05/2004	Melanin-concentrating hormone receptor mutations and human obesity: functional analysis.
05/2003	Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population.
03/2003	Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.
03/2003	Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms.
10/2002	Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease?
10/2002	Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.
08/2002	A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism.

Articles by Research Topic

Disease

15	Obesity 10/2008 - 08/2002
2	Hyperphagia 09/2007 - 12/2006
1	Narcolepsy 08/2007
1	Hypogonadism (Hypergonadotropic Hypogonadism) 01/2006
1	Syndrome 08/2005
1	Prader-Willi Syndrome (Syndrome, Prader-Willi) 01/2003
1	Cardiovascular Diseases (Cardiovascular Disease) 10/2002

Drug/Important Bio-Agent (IBA)

4	LeptinIBA 10/2008 - 10/2002
2	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 09/2006 - 08/2002
2	Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)IBA 03/2003 - 03/2003
1	LigandsIBA 10/2008
1	Proprotein Convertase 1IBA 09/2007
1	orexins (orexin)IBA 08/2007
1	Melanocortin Receptors (Melanocortin Receptor)IBA 01/2007
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 12/2006
1	LHRH Receptors (Gonadotropin-Releasing Hormone Receptor)IBA 01/2006
1	Peptide YYIBA 09/2004
1	neuropeptide Y2 receptorIBA 09/2004
1	Serotonin (5 Hydroxytryptamine)IBA 06/2004
1	melanin-concentrating hormone receptorIBA 05/2004
1	prolactin-releasing peptide receptorIBA 05/2003
1	GhrelinIBA 01/2003
1	Insulin (Novolin)FDA Link 01/2003