Epidermal Growth Factor Receptor

A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF related peptides including TRANSFORMING GROWTH FACTOR ALPHA, amphiregulin, and heparin-binding EGF-like growth factor. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.

Also Known As:

EGF Receptor; Receptor, Epidermal Growth Factor; Epidermal Growth Factor Receptor Kinase; Receptors, Epidermal Growth Factor; Epidermal Growth Factor Receptor Protein Tyrosine Kinase; Proto-Oncogene Protein, erbB-1; Receptor, TGF alpha; Receptor, Transforming Growth Factor alpha; Receptors, Epidermal Growth Factor Urogastrone; c erbB 1 Protein; erbB 1 Proto Oncogene Protein; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Receptor, EGF; Receptor, TGF-alpha; Receptor, Transforming-Growth Factor alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; TGF-alpha Receptor; Transforming Growth Factor alpha Receptor; Urogastrone Receptor; c-erbB-1 Protein; erbB-1 Proto-Oncogene Protein

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Enzymes and Coenzymes: 1

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Enzymes: 25587

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Transferases: 3318

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Phosphotransferases: 16262

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Phosphotransferases (Alcohol Group Acceptor)

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Protein Kinases: 5704

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Protein-Tyrosine Kinases: 6153

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Receptor Protein-Tyrosine Kinases: 252

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Epidermal Growth Factor Receptor: 7916

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Amino Acids, Peptides, and Proteins

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Proteins: 58433

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Membrane Proteins: 4125

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Cell Surface Receptors: 552

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Peptide Receptors: 308

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Growth Factor Receptors: 578

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Epidermal Growth Factor Receptor: 7916

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Gastrointestinal Hormone Receptors: 1

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Epidermal Growth Factor Receptor: 7916

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Receptor Protein-Tyrosine Kinases: 252

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Epidermal Growth Factor Receptor: 7916

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