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Emanuela Esposito Selected Research

Peroxynitrous Acid (Peroxynitrite)

12/2014A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways.
11/2013Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase.
7/2013Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance.
5/2012Targeting the overproduction of peroxynitrite for the prevention and reversal of paclitaxel-induced neuropathic pain.
11/2010Melatonin reduces hyperalgesia associated with inflammation.
10/2010Spinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive tolerance.
7/2009Effects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury.
6/2009Role of nitroso radicals as drug targets in circulatory shock.
1/2009Superoxide, NO, peroxynitrite and PARP in circulatory shock and inflammation.
9/2008Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity.
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Emanuela Esposito Research Topics

Disease

73Inflammation
12/2015 - 11/2002
39Spinal Cord Injuries (Spinal Cord Injury)
09/2015 - 07/2006
22Myelitis
01/2014 - 07/2006
15Edema
01/2014 - 08/2005
13Pain (Aches)
01/2015 - 11/2007
13Reperfusion Injury
02/2013 - 04/2007
13Wounds and Injuries (Trauma)
02/2013 - 10/2006
13Shock
06/2012 - 01/2006
12Brain Injuries (Brain Injury)
01/2016 - 09/2010
12Ischemia
09/2015 - 04/2007
11Body Weight (Weight, Body)
09/2015 - 11/2002
11Pleurisy (Pleuritis)
01/2012 - 08/2005
10Colitis
12/2015 - 11/2006
10Pneumonia (Pneumonitis)
10/2011 - 07/2006
8Lung Injury
09/2015 - 01/2007
8Hyperalgesia
01/2015 - 09/2008
8Multiple Organ Failure (MODS)
09/2011 - 11/2006
7Neoplasms (Cancer)
11/2015 - 01/2009
7Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
01/2010 - 11/2006
5Parkinson Disease (Parkinson's Disease)
01/2015 - 09/2010
5Neuralgia (Stump Neuralgia)
12/2014 - 05/2012
5Breast Neoplasms (Breast Cancer)
01/2014 - 12/2010
5Spinal Cord Compression
11/2013 - 03/2009
5Pancreatitis
07/2012 - 08/2006
4Fibrosis (Cirrhosis)
01/2015 - 07/2011
4Peripheral Nervous System Diseases (PNS Diseases)
12/2014 - 05/2012
4Insulin Resistance
03/2014 - 12/2010
4Brain Ischemia (Cerebral Ischemia)
06/2013 - 09/2010
4Arthritis (Polyarthritis)
01/2013 - 10/2011
3Neurodegenerative Diseases (Neurodegenerative Disease)
01/2014 - 09/2010
3Aneurysm (Aneurysms)
01/2014 - 08/2011
3Alzheimer Disease (Alzheimer's Disease)
01/2014 - 09/2010
3Hypersensitivity (Allergy)
11/2013 - 09/2008
3Stroke (Strokes)
06/2013 - 09/2010
3Obesity
01/2013 - 07/2004
3Experimental Arthritis
01/2013 - 10/2011
3Acute Lung Injury
01/2012 - 10/2006
3Septic Shock (Toxic Shock Syndrome)
01/2012 - 10/2006
3Necrosis
10/2011 - 08/2006

Drug/Important Bio-Agent (IBA)

273-nitrotyrosineIBA
09/2015 - 07/2006
21palmidrolIBA
12/2015 - 09/2007
18CarrageenanIBA
01/2015 - 08/2005
18Peroxidase (Myeloperoxidase)IBA
10/2012 - 08/2005
16Peroxynitrous Acid (Peroxynitrite)IBA
12/2014 - 10/2006
15Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2013 - 10/2006
14Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
09/2015 - 03/2006
14CytokinesIBA
07/2014 - 09/2007
14Peroxisome Proliferator-Activated Receptors (PPAR)IBA
01/2013 - 01/2006
11Transcription Factors (Transcription Factor)IBA
07/2014 - 01/2008
11MelatoninIBA
01/2014 - 10/2006
11ZymosanIBA
09/2011 - 10/2006
11PPAR alphaIBA
01/2010 - 08/2006
10NF-kappa B (NF-kB)IBA
07/2012 - 01/2007
8DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
05/2010 - 07/2006
72,4-dinitrofluorobenzene sulfonic acidIBA
12/2015 - 11/2006
6Bleomycin (Blenoxane)FDA LinkGeneric
09/2015 - 01/2007
6Superoxides (Superoxide)IBA
12/2014 - 01/2009
6Dexamethasone (Maxidex)FDA LinkGeneric
06/2013 - 10/2006
5NADPH Oxidase (NAD(P)H oxidase)IBA
12/2014 - 10/2010
5Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
01/2014 - 01/2007
5Caerulein (Ceruletide)IBA
07/2012 - 08/2006
5Protein Kinases (Protein Kinase)IBA
05/2012 - 04/2008
5Nitric Oxide (Nitrogen Monoxide)FDA Link
10/2011 - 10/2006
5acetovanillone (apocynin)IBA
03/2011 - 10/2010
5Fas Ligand Protein (Fas Ligand)IBA
01/2010 - 11/2006
5Fatty Acids (Saturated Fatty Acids)IBA
01/2010 - 02/2008
5Uridine Triphosphate (UTP)IBA
09/2008 - 09/2007
4Carbon MonoxideIBA
01/2016 - 10/2010
4Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
09/2015 - 11/2006
4LuteolinIBA
01/2015 - 01/2013
4Paclitaxel (Taxol)FDA LinkGeneric
12/2014 - 05/2012
4Superoxide DismutaseIBA
11/2013 - 06/2009
4Morphine (MS Contin)FDA LinkGeneric
07/2013 - 04/2009
4HormonesIBA
06/2013 - 11/2002
4oleuropeinIBA
02/2013 - 08/2011
4olive oilIBA
02/2013 - 08/2011
4GW0742IBA
07/2012 - 04/2010
4Lipase (Acid Lipase)FDA Link
07/2012 - 08/2006
4AmylasesFDA Link
07/2012 - 08/2006
4Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
10/2011 - 08/2006
4Adenosine A2A Receptor (Adenosine A2A Receptors)IBA
10/2011 - 05/2010
4acteosideIBA
10/2010 - 07/2009
4Estrogens (Estrogen)FDA Link
12/2009 - 07/2004
3oxaliplatin (Eloxatin)FDA LinkGeneric
01/2015 - 11/2013
3Dimethyl Sulfoxide (DMSO)FDA LinkGeneric
01/2014 - 07/2011
3triphenyltetrazoliumIBA
06/2013 - 10/2012
3Urea (Carbamide)FDA LinkGeneric
01/2013 - 05/2011
3CreatinineIBA
01/2013 - 05/2011
3Collagen Type II (Type II Collagen)IBA
01/2013 - 10/2011
3Glucose (Dextrose)FDA LinkGeneric
01/2013 - 01/2007
3TransferasesIBA
10/2012 - 05/2011
3Proteins (Proteins, Gene)IBA
07/2012 - 02/2008
3PD 98059IBA
05/2012 - 04/2008
3olprinoneIBA
10/2011 - 01/2010
32- (4- (2- carboxyethyl)phenethylamino)- 5'- N- ethylcarboxamidoadenosineIBA
10/2011 - 05/2010
3P-SelectinIBA
10/2011 - 08/2006

Therapy/Procedure

27Laminectomy
01/2014 - 07/2006
6Intraperitoneal Injections
07/2012 - 08/2006
5Drug Therapy (Chemotherapy)
12/2015 - 05/2012
4Surgical Instruments (Clip)
01/2014 - 09/2007