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Germaine Escames Selected Research

Melatonin

9/2015Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice.
1/2015Identification of mitochondrial deficits and melatonin targets in liver of septic mice by high-resolution respirometry.
1/2015Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis.
5/2014Protective actions of melatonin and growth hormone on the aged cardiovascular system.
1/2014The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS.
11/2011Beneficial effect of melatonin treatment on inflammation, apoptosis and oxidative stress on pancreas of a senescence accelerated mice model.
10/2011Synergism between melatonin and atorvastatin against endothelial cell damage induced by lipopolysaccharide.
7/2011Melatonin treatment counteracts the hyperoxidative status in erythrocytes of patients suffering from Duchenne muscular dystrophy.
12/2010Melatonin improves inflammation processes in liver of senescence-accelerated prone male mice (SAMP8).
9/2010The role of mitochondria in brain aging and the effects of melatonin.
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Germaine Escames Research Topics

Disease

12Sepsis (Septicemia)
09/2015 - 01/2003
8Inflammation
09/2015 - 09/2006
4Neurodegenerative Diseases (Neurodegenerative Disease)
07/2014 - 01/2003
3Parkinson Disease (Parkinson's Disease)
10/2009 - 05/2003
3Endotoxemia
04/2007 - 05/2003
2Neoplasms (Cancer)
01/2015 - 10/2005
2Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
07/2011 - 04/2010
2Sickle Cell Anemia (Hemoglobin S Disease)
05/2011 - 12/2010
2Neuromuscular Diseases (Neuromuscular Disease)
01/2011 - 02/2002
2Necrosis
08/2010 - 10/2005
2Colonic Neoplasms (Colon Cancer)
09/2007 - 10/2005
1Mitochondrial Myopathies (Mitochondrial Myopathy)
05/2015
1Ulcer
01/2015
1Mucositis
01/2015
1Stomatitis
01/2015
1Body Weight (Weight, Body)
07/2014
1Mitochondrial Diseases (Mitochondrial Disease)
07/2014
1Cerebellar Ataxia (Dysmetria)
07/2014
1Muscular Dystrophies (Muscular Dystrophy)
07/2011
1Oral Manifestations
10/2006
1Septic Shock (Toxic Shock Syndrome)
09/2006
1Shock
09/2006
1Multiple Organ Failure (MODS)
09/2006
1Anoxia (Hypoxia)
07/2005
1Hypertension (High Blood Pressure)
03/2004
1Seizures (Seizure)
08/2003
1Nervous System Diseases (Neurological Disorders)
01/2002

Drug/Important Bio-Agent (IBA)

25MelatoninIBA
09/2015 - 01/2003
6Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2014 - 01/2003
5Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
01/2014 - 03/2004
3Glutathione (Reduced Glutathione)IBA
01/2014 - 10/2006
3Mitochondrial DNA (mtDNA)IBA
02/2012 - 02/2002
31- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
10/2009 - 05/2003
2EnzymesIBA
01/2014 - 10/2006
2GlobinsIBA
05/2011 - 12/2010
2DNA (Deoxyribonucleic Acid)IBA
01/2011 - 02/2002
2CytokinesIBA
08/2010 - 04/2010
2Nitric Oxide Synthase (NO Synthase)IBA
04/2007 - 09/2006
2Adenosine Triphosphate (ATP)IBA
04/2007 - 10/2006
2Peroxynitrous Acid (Peroxynitrite)IBA
09/2006 - 01/2003
1Transcription Factors (Transcription Factor)IBA
09/2015
1ubiquinone 9IBA
05/2015
1Succinic Acid (Succinate)IBA
01/2015
1RotenoneIBA
01/2015
1malic acid (malate)IBA
01/2015
1Glutamic Acid (Glutamate)FDA Link
01/2015
1Leucine (L-Leucine)FDA Link
01/2015
1Reactive Oxygen Species (Oxygen Radicals)IBA
01/2015
1ubiquinol-10IBA
07/2014
1coenzyme Q10 (CoQ10)IBA
07/2014
1Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
05/2014
1NitritesIBA
01/2014
1Proteins (Proteins, Gene)IBA
01/2014
1Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA
01/2014
1atorvastatin (Lipitor)FDA Link
10/2011
1Sepharose (Agarose)IBA
05/2011
1OxidoreductasesIBA
08/2010
1Interleukin-1beta (Interleukin 1 beta)IBA
08/2010
1Creatine Kinase (Creatine Phosphokinase)IBA
08/2010
1Interleukin-6 (Interleukin 6)IBA
08/2010
1Glutathione PeroxidaseIBA
08/2010
1DystrophinIBA
04/2010
1Protein Isoforms (Isoforms)IBA
04/2007
1Adenosine Triphosphatases (ATPase)IBA
10/2006
1Annexin A5IBA
10/2005
1IodineIBA
10/2005
1Cholecystokinin (Pancreozymin)IBA
10/2005
1Fluorescein-5-isothiocyanate (FITC)IBA
10/2005
1Propidium (Propidium Iodide)IBA
10/2005
1Cholecystokinin Receptors (Cholecystokinin Receptor)IBA
10/2005
1OxygenIBA
07/2005
1lacidipineIBA
03/2004
1Amino AcidsFDA Link
08/2003
1Pentylenetetrazole (Metrazol)IBA
08/2003
1Selegiline (E250)FDA LinkGeneric
05/2003
1N-Methylaspartate (NMDA)IBA
01/2002
1Glutamate Receptors (Glutamate Receptor)IBA
01/2002

Therapy/Procedure

4Ligation
01/2015 - 02/2006
1Radiotherapy
01/2015
1Drug Therapy (Chemotherapy)
01/2015
1Aftercare (After-Treatment)
10/2006