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Frank Entschladen Selected Research

Neurotransmitter Agents (Neurotransmitter)

2/2012Norepinephrine promotes the β1-integrin-mediated adhesion of MDA-MB-231 cells to vascular endothelium by the induction of a GROα release.
1/2010Tumor interactions with soluble factors and the nervous system.
6/2008The cancer's nervous tooth: Considering the neuronal crosstalk within tumors.
1/2007Neoneurogenesis and the neuro-neoplastic synapse.
1/2007Connecting a tumor to the environment.
6/2006The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockers.
1/2006Neoneurogenesis: tumors may initiate their own innervation by the release of neurotrophic factors in analogy to lymphangiogenesis and neoangiogenesis.
1/2005Neurotransmitters and chemokines regulate tumor cell migration: potential for a new pharmacological approach to inhibit invasion and metastasis development.
12/2004Inhibition of cell migration via G protein-coupled receptors to opioid peptides and angiotensin.
11/2004Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs.
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Frank Entschladen Research Topics

Disease

25Neoplasms (Cancer)
10/2015 - 06/2002
14Carcinoma (Carcinomatosis)
02/2012 - 06/2002
11Neoplasm Metastasis (Metastasis)
10/2015 - 11/2002
4Breast Neoplasms (Breast Cancer)
10/2015 - 03/2008
2Inflammation
01/2015 - 04/2011
2Pancreatic Neoplasms (Pancreatic Cancer)
08/2014 - 07/2013
1Periodontitis
01/2015
1Anoxia (Hypoxia)
01/2011
1Lymphoid Leukemia
12/2010
1Colonic Neoplasms (Colon Cancer)
03/2010
1Colorectal Neoplasms (Colorectal Cancer)
03/2010
1Obesity
03/2010
1Wounds and Injuries (Trauma)
03/2008
1Prostatic Neoplasms (Prostate Cancer)
06/2006
1Encephalitis (Encephalitis, Rasmussen)
08/2004
1Astrocytoma (Pilocytic Astrocytoma)
08/2004
1Melanoma (Melanoma, Malignant)
01/2003
1Fibrosarcoma
01/2003
1Epilepsy (Aura)
11/2002

Drug/Important Bio-Agent (IBA)

14Neurotransmitter Agents (Neurotransmitter)IBA
02/2012 - 11/2002
10Norepinephrine (Noradrenaline)FDA LinkGeneric
07/2013 - 08/2004
8CollagenIBA
01/2015 - 06/2002
4Phosphotransferases (Kinase)IBA
10/2015 - 01/2010
3tyrosine receptor (receptor, tyrosine)IBA
10/2015 - 07/2013
3CytokinesIBA
01/2013 - 01/2007
3Interleukin-8 (Interleukin 8)IBA
01/2011 - 06/2002
3ChemokinesIBA
01/2007 - 01/2005
2GelsolinIBA
10/2015 - 11/2004
2GTP-Binding Proteins (G-Protein)IBA
04/2011 - 06/2006
2Nerve Growth Factor (NGF)IBA
01/2011 - 06/2008
2Propranolol (Inderal)FDA LinkGeneric
11/2010 - 06/2006
2Nerve Growth Factors (Neurotrophins)IBA
06/2008 - 01/2006
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
06/2008 - 01/2007
1Messenger RNA (mRNA)IBA
10/2015
1Estrogens (Estrogen)FDA Link
10/2015
1Materia Medica (Homeopathic Remedies)IBA
01/2015
1Epidermal Growth Factor Receptor (EGF Receptor)IBA
08/2014
1Protein Kinase C-alphaIBA
07/2013
1Phospholipase C gammaIBA
07/2013
1Heterotrimeric GTP-Binding Proteins (Heterotrimeric G-Proteins)IBA
04/2011
1OxygenIBA
01/2011
1Conditioned Culture MediaIBA
01/2011
1Interleukin-2 (IL2)IBA
01/2011
1Phenobarbital (Luminal)FDA Link
01/2011
1myosin VIIBA
12/2010
1Myosins (Myosin)IBA
12/2010
1Antihypertensive Agents (Antihypertensives)IBA
11/2010
1LigandsIBA
03/2010
1LeptinIBA
03/2010
1p38 Mitogen-Activated Protein KinasesIBA
01/2010
1Focal Adhesion Protein-Tyrosine KinasesIBA
01/2010
1Small Interfering RNA (siRNA)IBA
01/2010
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
01/2010
1rho-Associated KinasesIBA
01/2010
1PaxillinIBA
01/2010
1EnzymesIBA
02/2009
1Type C PhospholipasesIBA
02/2009
1brain-derived growth factorIBA
06/2008
1HormonesIBA
01/2007
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
06/2006
1Adenylate Cyclase (Adenylyl Cyclase)IBA
12/2004
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
12/2004
1Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)IBA
12/2004
1Methionine EnkephalinIBA
12/2004
1Dopamine (Intropin)FDA LinkGeneric
11/2004
1Integrin alpha2IBA
11/2004
1adhesion receptorIBA
11/2004
1Substance PIBA
11/2004
1Neurokinin-1 Receptors (Neurokinin 1 Receptor)IBA
11/2004
1anandamide (arachidonylethanolamide)IBA
08/2004
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2004
1Cannabinoid Receptors (Cannabinoid Receptor)IBA
08/2004
1Neurotransmitter Receptors (Neurotransmitter Receptor)IBA
04/2004
1Matrix MetalloproteinasesIBA
01/2003
1Type II DNA Topoisomerases (Topoisomerase II)IBA
01/2003
1boswellic acidIBA
01/2003
1DNA (Deoxyribonucleic Acid)IBA
01/2003
1GelatinIBA
01/2003
1gamma-Aminobutyric Acid (GABA)IBA
11/2002
1Fluo-3IBA
06/2002
1beta-arrestinIBA
06/2002
1CalciumIBA
06/2002

Therapy/Procedure

1Drug Therapy (Chemotherapy)
11/2010
1Therapeutics
03/2010
1Ligation
01/2010
1Segmental Mastectomy (Lumpectomy)
03/2008
1Radiotherapy
03/2008
1Lasers (Laser)
06/2002