Keratins

A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.

Also Known As:

Keratin; Cytokeratin; Glycosylated Keratin; Keratin, Glycosylated; Keratin-Associated Proteins; alpha-Keratin; Keratin Associated Proteins; alpha Keratin

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Macromolecular Substances: 43

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Polymers: 3257

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Biopolymers: 137

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Intermediate Filament Proteins: 229

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Keratins: 6212

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Amino Acids, Peptides, and Proteins

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Proteins: 58433

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Cytoskeletal Proteins: 432

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Intermediate Filament Proteins: 229

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Keratins: 6212

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Scleroproteins: 11

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Keratins: 6212

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