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Mitch Dowsett Selected Research

Breast Neoplasms (Breast Cancer)

11/2015Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer.
9/2015AKT Antagonist AZD5363 Influences Estrogen Receptor Function in Endocrine-Resistant Breast Cancer and Synergizes with Fulvestrant (ICI182780) In Vivo.
8/2015Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer.
7/2015Accurate Prediction and Validation of Response to Endocrine Therapy in Breast Cancer.
7/2015Antiproliferative Effect of Lapatinib in HER2-Positive and HER2-Negative/HER3-High Breast Cancer: Results of the Presurgical Randomized MAPLE Trial (CRUK E/06/039).
6/2015Estrogen Receptor Expression in 21-Gene Recurrence Score Predicts Increased Late Recurrence for Estrogen-Positive/HER2-Negative Breast Cancer.
6/2015Progesterone receptor A predominance is a discriminator of benefit from endocrine therapy in the ATAC trial.
3/2015Prediction of late distant recurrence after 5 years of endocrine treatment: a combined analysis of patients from the Austrian breast and colorectal cancer study group 8 and arimidex, tamoxifen alone or in combination randomized trials using the PAM50 risk of recurrence score.
1/2015Erratum to: Differences in expression of proliferation-associated genes and RANKL across the menstrual cycle in estrogen receptor-positive primary breast cancer.
1/2015Reduced progesterone levels explain the reduced risk of breast cancer in obese premenopausal women: a new hypothesis.
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Mitch Dowsett Research Topics

Disease

180Breast Neoplasms (Breast Cancer)
11/2015 - 01/2002
88Neoplasms (Cancer)
11/2015 - 01/2002
7Carcinoma (Carcinomatosis)
08/2014 - 10/2003
4Prostatic Neoplasms (Prostate Cancer)
02/2012 - 11/2005
3Overweight
04/2014 - 07/2010
3Hypersensitivity (Allergy)
07/2005 - 08/2002
3Bone Resorption
02/2004 - 07/2002
2Endometrial Neoplasms (Endometrial Cancer)
02/2016 - 12/2010
2Residual Neoplasm
08/2015 - 07/2012
2Colorectal Neoplasms (Colorectal Cancer)
03/2015 - 09/2010
2Arthralgia (Joint Pain)
12/2014 - 09/2013
2Amenorrhea
08/2013 - 06/2006
2Weight Gain
07/2012 - 06/2007
2Cardiovascular Diseases (Cardiovascular Disease)
03/2012 - 12/2007
2Hypertension (High Blood Pressure)
02/2012 - 10/2008
2Hypokalemia
02/2012 - 10/2008
2Neoplasm Metastasis (Metastasis)
09/2008 - 10/2007
1Thymoma (Thymic Carcinoma)
01/2015
1Obesity
01/2015
1Lethargy
09/2013
1Vomiting
09/2013
1Nausea
09/2013
1Endometrial Hyperplasia
07/2013

Drug/Important Bio-Agent (IBA)

85Estrogens (Estrogen)FDA Link
11/2015 - 01/2002
52TamoxifenFDA LinkGeneric
09/2015 - 01/2002
47HormonesIBA
03/2015 - 01/2003
39Aromatase InhibitorsIBA
07/2015 - 07/2002
37anastrozole (Arimidex)FDA LinkGeneric
06/2015 - 02/2002
25Aromatase (CYP19)IBA
01/2015 - 01/2002
24Estradiol (Estrace)FDA LinkGeneric
02/2016 - 01/2005
20Progesterone Receptors (Progesterone Receptor)IBA
06/2015 - 01/2003
16Biological Markers (Surrogate Marker)IBA
01/2015 - 08/2003
14letrozole (Femara)FDA LinkGeneric
07/2015 - 02/2002
13Epidermal Growth Factor Receptor (EGF Receptor)IBA
07/2014 - 01/2005
12trastuzumab (Herceptin)FDA Link
07/2014 - 01/2002
11Gonadal Steroid Hormones (Sex Hormones)IBA
05/2014 - 01/2006
8Estrogen Receptor alphaIBA
07/2015 - 08/2002
8Estrone (Folliculin)FDA Link
01/2014 - 10/2006
8ParaffinIBA
02/2013 - 01/2004
7DNA (Deoxyribonucleic Acid)IBA
11/2015 - 01/2007
7Testosterone (Sustanon)FDA Link
07/2013 - 11/2005
7Formaldehyde (Formol)FDA Link
06/2012 - 03/2008
7Sex Hormone-Binding GlobulinIBA
03/2012 - 11/2005
5Phenobarbital (Luminal)FDA Link
11/2015 - 08/2007
5fulvestrant (Faslodex)FDA Link
09/2015 - 01/2005
5Messenger RNA (mRNA)IBA
07/2015 - 03/2002
5Proteins (Proteins, Gene)IBA
06/2015 - 08/2002
5ProgesteroneFDA LinkGeneric
01/2015 - 10/2006
5SteroidsIBA
08/2013 - 07/2005
5Raloxifene (Evista)FDA Link
05/2013 - 10/2003
5AndrogensIBA
09/2010 - 07/2002
4Selective Estrogen Receptor Modulators (SERM)IBA
05/2013 - 08/2003
4RNA (Ribonucleic Acid)IBA
01/2012 - 03/2010
4Ki-67 Antigen (Ki 67 Antigen)IBA
11/2011 - 08/2003
4Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
06/2009 - 01/2003
3Phosphotransferases (Kinase)IBA
09/2015 - 11/2010
3estrone sulfate (Evex)FDA Link
08/2012 - 10/2006
3abirateroneIBA
02/2012 - 10/2008
3Cyclin D1IBA
01/2012 - 10/2003
3Carbon MonoxideIBA
11/2011 - 05/2008
3Estrogen Receptor Modulators (Antiestrogen)IBA
09/2011 - 10/2003
3Epidermal Growth Factor (EGF)IBA
10/2009 - 04/2003
3Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA
08/2009 - 06/2004
3Androstenedione (4 Androstene 3,17 dione)IBA
06/2008 - 07/2006
3IsoflavonesIBA
09/2006 - 01/2004
3Phytoestrogens (Phytoestrogen)IBA
11/2005 - 05/2004
3Complementary DNA (cDNA)IBA
01/2004 - 01/2002
2lapatinib (GW572016)FDA Link
07/2015 - 03/2010
2Androgen Receptors (Androgen Receptor)IBA
08/2014 - 10/2008
2Cytochrome P-450 CYP3AIBA
01/2014 - 05/2012
2Cytochrome P-450 CYP2D6 (CYP2D6)IBA
07/2013 - 03/2012
2Dexamethasone (Maxidex)FDA LinkGeneric
02/2012 - 08/2009
2ChromatinIBA
01/2012 - 09/2011
2Sirolimus (Rapamycin)FDA Link
01/2012 - 11/2010
2Caveolin 1IBA
01/2012 - 01/2012
2Protein Kinases (Protein Kinase)IBA
11/2010 - 04/2005
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
06/2009 - 05/2008
2Angiogenesis InhibitorsIBA
06/2009 - 09/2007
2AnthracyclinesIBA
05/2008 - 12/2007
2Dehydroepiandrosterone SulfateIBA
12/2007 - 05/2006
2Estrogen ReceptorsIBA
10/2007 - 11/2003
2Farnesyltranstransferase (Farnesyltransferase)IBA
09/2007 - 05/2005
2tipifarnib (R115777)IBA
09/2007 - 07/2003
2gefitinib (Iressa)FDA Link
09/2007 - 01/2005
2Cyclophosphamide (Cytoxan)FDA LinkGeneric
02/2006 - 01/2006
2Steroid Receptors (Steroid Receptor)IBA
12/2005 - 05/2005
2TransferasesIBA
07/2003 - 01/2003
1risedronic acid (risedronate)FDA LinkGeneric
12/2014
1Phosphatidylinositols (Phosphatidylinositol)IBA
01/2014
1Chemokine ReceptorsIBA
01/2014
1exemestane (Aromasin)FDA Link
09/2013
1Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
06/2013
1Proto-Oncogene Proteins c-retIBA
06/2013

Therapy/Procedure

19Drug Therapy (Chemotherapy)
11/2015 - 01/2002
7Heterologous Transplantation (Xenotransplantation)
09/2015 - 03/2002
7Adjuvant Chemotherapy
09/2013 - 10/2005
6Chemoprevention
04/2008 - 01/2006
5Neoadjuvant Therapy
01/2015 - 01/2005
3Castration
02/2012 - 10/2008
2Lasers (Laser)
11/2003 - 10/2003