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James H Doroshow Selected Research

Topotecan (Hycamtin)

12/2014ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses.
9/2014Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.
1/2012Development and validation of an immunoassay for quantification of topoisomerase I in solid tumor tissues.
12/2011Poly(ADP-ribose) polymerase inhibition enhances p53-dependent and -independent DNA damage responses induced by DNA damaging agent.
9/2011Phase I study of PARP inhibitor ABT-888 in combination with topotecan in adults with refractory solid tumors and lymphomas.
8/2011Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1α in advanced solid tumors.
11/2010Development of a validated immunofluorescence assay for γH2AX as a pharmacodynamic marker of topoisomerase I inhibitor activity.
10/2010Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase I trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors.
2/2010Monitoring drug-induced gammaH2AX as a pharmacodynamic biomarker in individual circulating tumor cells.

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James H Doroshow Research Topics

Disease

86Neoplasms (Cancer)
10/2015 - 05/2002
8Lymphoma (Lymphomas)
06/2014 - 11/2009
8Breast Neoplasms (Breast Cancer)
05/2013 - 01/2003
6Colorectal Neoplasms (Colorectal Cancer)
09/2015 - 08/2003
6Carcinoma (Carcinomatosis)
06/2015 - 05/2002
6Ovarian Neoplasms (Ovarian Cancer)
04/2015 - 10/2004
6Inflammation
06/2014 - 06/2004
5Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
07/2006 - 01/2004
4Neoplasm Metastasis (Metastasis)
04/2014 - 08/2003
4Anoxia (Hypoxia)
04/2014 - 10/2003
4Prostatic Neoplasms (Prostate Cancer)
04/2013 - 02/2004
3Chronic Pancreatitis
06/2015 - 02/2013
3Genomic Instability
04/2015 - 04/2014
3Colitis
03/2014 - 04/2003
3Pancreatic Neoplasms (Pancreatic Cancer)
04/2013 - 04/2011
3Vomiting
10/2010 - 10/2003
2Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
06/2015 - 04/2013
2Necrosis
06/2015 - 08/2012
2Fanconi Anemia (Fanconi's Anemia)
04/2015 - 11/2012
2Crohn Disease (Crohn's Disease)
03/2014 - 04/2003
2Renal Cell Carcinoma (Grawitz Tumor)
04/2013 - 10/2003
2Colonic Neoplasms (Colon Cancer)
04/2013 - 05/2012
2Sarcoma (Soft Tissue Sarcoma)
07/2012 - 09/2004
2Disease Progression
07/2012 - 09/2005
2Circulating Neoplastic Cells
03/2012 - 09/2011
2Neutropenia
10/2010 - 10/2003
2Liver Diseases (Liver Disease)
02/2008 - 08/2003
2Diarrhea
02/2007 - 09/2005
2Respiratory Insufficiency (Respiratory Failure)
02/2007 - 06/2005
2Nausea
02/2007 - 09/2005
1Shock
08/2015
1Fallopian Tube Neoplasms
04/2015

Drug/Important Bio-Agent (IBA)

15DNA (Deoxyribonucleic Acid)IBA
04/2015 - 01/2003
11Reactive Oxygen Species (Oxygen Radicals)IBA
06/2014 - 06/2004
9Topotecan (Hycamtin)FDA LinkGeneric
12/2014 - 02/2010
8OxidoreductasesIBA
06/2015 - 06/2009
6Phosphotransferases (Kinase)IBA
10/2015 - 02/2004
6Type I DNA Topoisomerases (Topoisomerase I)IBA
12/2014 - 07/2009
6PlatinumIBA
04/2012 - 11/2002
6docetaxel (Taxotere)FDA Link
07/2006 - 05/2002
5Messenger RNA (mRNA)IBA
04/2015 - 01/2003
5NADPH Oxidase (NAD(P)H oxidase)IBA
04/2014 - 06/2009
5Cisplatin (Platino)FDA LinkGeneric
09/2012 - 01/2003
5Poly Adenosine Diphosphate RiboseIBA
03/2012 - 06/2009
5Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
12/2011 - 11/2008
52- ((R)- 2- methylpyrrolidin- 2- yl)- 1H- benzimidazole- 4- carboxamideIBA
09/2011 - 11/2008
5gemcitabineFDA Link
01/2010 - 11/2002
5oxaliplatin (Eloxatin)FDA LinkGeneric
11/2009 - 08/2003
4CytokinesIBA
04/2014 - 04/2011
4OxygenIBA
02/2014 - 04/2011
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
07/2012 - 10/2003
4Carboplatin (JM8)FDA LinkGeneric
10/2010 - 10/2003
4HormonesIBA
03/2006 - 05/2002
3Proteins (Proteins, Gene)IBA
08/2015 - 10/2003
3NADP (NADPH)IBA
06/2015 - 04/2013
3Protein Isoforms (Isoforms)IBA
06/2015 - 01/2012
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
04/2015 - 01/2004
3AntibodiesIBA
06/2014 - 12/2003
3bevacizumabFDA Link
04/2014 - 05/2011
3Glutathione (Reduced Glutathione)IBA
03/2014 - 06/2004
3PeroxidasesIBA
03/2014 - 06/2004
3CyclinsIBA
04/2013 - 02/2004
3ParaffinIBA
11/2009 - 05/2002
3Doxorubicin (Adriamycin)FDA LinkGeneric
06/2007 - 01/2004
3Paclitaxel (Taxol)FDA LinkGeneric
11/2005 - 10/2003
3trastuzumab (Herceptin)FDA Link
05/2004 - 05/2002
2cetuximab (Erbitux)FDA Link
09/2015 - 11/2006
2sorafenib (BAY 43-9006)FDA Link
09/2015 - 07/2012
2Heat-Shock Proteins (Heat-Shock Protein)IBA
08/2015 - 01/2010
2Interleukin-13IBA
06/2015 - 05/2012
2irinotecan (Camptosar)FDA LinkGeneric
12/2014 - 09/2014
2CamptothecinIBA
12/2014 - 09/2014
2EnzymesIBA
06/2014 - 03/2014
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
04/2014 - 04/2011
2NADPH oxidase 1IBA
03/2014 - 04/2013
24- ((4- Fluoro- 2- methyl- 1H- indol- 5- yl)oxy)- 6- methoxy- 7- (3- (pyrrolidin- 1- yl)propoxy)quinazoline (AZD2171)IBA
06/2013 - 07/2012
2diphenyleneiodoniumIBA
04/2013 - 05/2012
2FlavoproteinsIBA
04/2013 - 05/2012
2iodonium thiopheneIBA
04/2013 - 05/2012
2Razoxane (Dexrazoxane)FDA LinkGeneric
08/2012 - 09/2004
2Glutathione PeroxidaseIBA
01/2012 - 04/2003
2bortezomib (Velcade)FDA Link
01/2010 - 02/2006
27-hydroxystaurosporine (UCN 01)IBA
01/2010 - 06/2005
2Ribonucleotide Reductases (Ribonucleotide Reductase)IBA
11/2009 - 01/2003
2N- (2- aminophenyl)- 4- (N- (pyridin- 3- ylmethoxycarbonyl)aminomethyl)benzamide (MS 275)IBA
09/2007 - 02/2006
2Fluorouracil (Carac)FDA LinkGeneric
11/2006 - 12/2003
2CreatinineIBA
06/2005 - 08/2003
2taxaneIBA
05/2004 - 01/2004
2AntigensIBA
12/2003 - 05/2002
1Histones (Histone)IBA
10/2015
1(2,4- dihydroxy- 5- isopropylphenyl)- (5- (4- methylpiperazin- 1- ylmethyl)- 1,3- dihydroisoindol- 2- yl)methanoneIBA
08/2015
1Molecular Chaperones (Chaperone, Molecular)IBA
08/2015
1InterferonsIBA
06/2015
1InterleukinsIBA
06/2015
1MK 2206IBA
06/2015
1Topoisomerase InhibitorsIBA
04/2015

Therapy/Procedure

15Drug Therapy (Chemotherapy)
07/2012 - 05/2002
7Heterologous Transplantation (Xenotransplantation)
06/2014 - 11/2008
4Therapeutics
11/2014 - 07/2009
2Oral Administration
03/2012 - 03/2005