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J Alan Diehl Selected Research

Cyclin D1

3/2015PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers.
1/2015PRMT5-dependent p53 escape in tumorigenesis.
1/2015FBXO4 loss facilitates carcinogen induced papilloma development in mice.
11/2013The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma.
1/2012Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma.
11/2011The Fbx4 tumor suppressor regulates cyclin D1 accumulation and prevents neoplastic transformation.
10/2010Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.
8/2009Nuclear cyclin D1: an oncogenic driver in human cancer.
3/2009DNA damage-dependent cyclin D1 proteolysis: GSK3beta holds the smoking gun.
12/2008Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability.
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J Alan Diehl Research Topics

Disease

35Neoplasms (Cancer)
12/2015 - 05/2002
5Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2015 - 09/2008
4Genomic Instability
11/2011 - 01/2008
3Carcinoma (Carcinomatosis)
06/2011 - 11/2003
2Neoplasm Metastasis (Metastasis)
07/2015 - 01/2014
2Lymphoma (Lymphomas)
03/2015 - 10/2010
2Anoxia (Hypoxia)
01/2014 - 11/2008
2Insulin Resistance
06/2012 - 03/2011
2Inflammation
04/2011 - 03/2011
2Breast Neoplasms (Breast Cancer)
01/2011 - 05/2002
2Infection
01/2010 - 01/2009
2Retinoblastoma (Glioblastoma, Retinal)
01/2007 - 05/2002
1Neurodegenerative Diseases (Neurodegenerative Disease)
12/2015
1Glioblastoma (Glioblastoma Multiforme)
07/2015
1Amyloid Plaque
01/2015
1Alzheimer Disease (Alzheimer's Disease)
01/2015
1Melanoma (Melanoma, Malignant)
11/2013
1Squamous Cell Neoplasms (Squamous Cell Cancer)
09/2013
1Tuberous Sclerosis (Bourneville's Disease)
05/2013
1Obesity
06/2012
1Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)
02/2012
1Hyperplasia
01/2012
1Noninfiltrating Intraductal Carcinoma (DCIS)
09/2011
1Breast Ductal Carcinoma
09/2011
1Residual Neoplasm
06/2011
1Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
09/2006
1Prostatic Neoplasms (Prostate Cancer)
01/2005
1Adenocarcinoma
01/2005
1Esophageal Neoplasms (Esophageal Cancer)
11/2003
1Starvation
04/2002

Drug/Important Bio-Agent (IBA)

23Cyclin D1IBA
03/2015 - 05/2002
11CyclinsIBA
11/2011 - 05/2002
10Phosphotransferases (Kinase)IBA
12/2015 - 04/2002
5Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
11/2013 - 11/2006
4Insulin (Novolin)FDA Link
01/2014 - 08/2010
3Arginine (L-Arginine)FDA Link
03/2015 - 10/2010
3UbiquitinIBA
11/2013 - 10/2008
3Crystallins (Crystallin)IBA
10/2008 - 11/2006
2Activating Transcription Factor 4IBA
07/2015 - 01/2015
2OxygenIBA
06/2015 - 05/2013
2Reactive Oxygen Species (Oxygen Radicals)IBA
01/2014 - 11/2008
2Proteins (Proteins, Gene)IBA
03/2011 - 11/2008
2Peptide Initiation Factors (Initiation Factor)IBA
03/2011 - 04/2002
2Protein Kinases (Protein Kinase)IBA
01/2009 - 09/2008
2DNA (Deoxyribonucleic Acid)IBA
01/2008 - 11/2007
1Wolcott-Rallison syndromeIBA
12/2015
1Heme Oxygenase-1IBA
07/2015
1Adenocarcinoma of lungIBA
07/2015
1Carbon MonoxideIBA
02/2015
1Amyloid (Amyloid Fibrils)IBA
01/2015
1PERK kinaseIBA
01/2015
1Amyloid Precursor Protein Secretases (beta-Secretase)IBA
01/2015
16- acetyl- 8- cyclopentyl- 5- methyl- 2- (5- piperazin- 1- ylpyridin- 2- ylamino)- 8H- pyrido(2,3- d)pyrimidin- 7- oneIBA
01/2015
1Insulin-Like Growth Factor Binding Protein 3IBA
01/2014
1Hyaluronic Acid (Hyaluronan)IBA
01/2014
1Cyclin-Dependent Kinase Inhibitor p16IBA
11/2013
1tyrosine receptor (receptor, tyrosine)IBA
09/2013
1LipidsIBA
05/2013
1Glucose (Dextrose)FDA LinkGeneric
05/2013
1Inositol (Myoinositol)IBA
05/2013
1Glycogen Synthase (Synthase I)IBA
02/2012
1MicroRNAs (MicroRNA)IBA
11/2011
1Phenobarbital (Luminal)FDA Link
09/2011
1VimentinIBA
06/2011
1Cisplatin (Platino)FDA LinkGeneric
06/2011
1salinomycinIBA
06/2011
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
04/2011
1Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
04/2011
1Macrophage Colony-Stimulating FactorIBA
04/2011
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
04/2011
1delta cateninIBA
04/2011
1tauroursodeoxycholic acidIBA
03/2011
1Nonesterified Fatty Acids (NEFA)IBA
03/2011
1Histones (Histone)IBA
10/2010
1Carrier Proteins (Binding Protein)IBA
08/2010
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
06/2010
1LigandsIBA
01/2010
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
11/2008
1bortezomib (Velcade)FDA Link
09/2008
1glycogen synthase kinase 3 betaIBA
07/2008
1sorafenib (BAY 43-9006)FDA Link
10/2007
1Cyclin DIBA
01/2007
1Retinoblastoma ProteinIBA
01/2007
1Staphylococcal Protein A (A, Protein)IBA
03/2006
1HormonesIBA
01/2005
1histone deacetylase 3IBA
01/2005
1Immune Sera (Antisera)IBA
11/2003
1Cyclin EIBA
09/2003
1ZearalenoneIBA
05/2002
1Messenger RNA (mRNA)IBA
04/2002

Therapy/Procedure

4Heterologous Transplantation (Xenotransplantation)
06/2015 - 10/2007
2Therapeutics
09/2013 - 01/2005
2Drug Therapy (Chemotherapy)
06/2011 - 03/2009
1Transplantation (Transplant Recipients)
01/2014
1Chemoprevention
07/2005