Mark W Dewhirst Selected Research

Oxygen

01/2008	Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors.
02/2006	Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor.
06/2005	Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat.
05/2005	Oxygen regulation of tumor perfusion by S-nitrosohemoglobin reveals a pressor activity of nitric oxide.
09/2004	Tumor-dependent kinetics of partial pressure of oxygen fluctuations during air and oxygen breathing.
08/2003	Effect of longitudinal oxygen gradients on effectiveness of manipulation of tumor oxygenation.
03/2003	A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics.
05/2002	A theoretical model for the effects of reduced hemoglobin-oxygen affinity on tumor oxygenation.
04/2002	Hypoxia in the thymus: role of oxygen tension in thymocyte survival.

Articles by Research Topic

Disease

29	Neoplasms (Cancer) 05/2008 - 05/2002
5	Anoxia (Hypoxia) 06/2008 - 04/2002
5	Fever (Fevers) 11/2006 - 03/2003
5	Breast Neoplasms (Breast Cancer) 05/2006 - 11/2003
3	Small Cell Carcinoma 01/2008 - 12/2004
2	Carcinoma (Carcinomatosis) 03/2006 - 07/2003
1	Inflammation 07/2008
1	Astrocytoma (Pilocytic Astrocytoma) 01/2008
1	Ischemia 08/2007
1	Sarcoma (Soft Tissue Sarcoma) 01/2007
1	Neoplasm Metastasis (Metastasis) 05/2006
1	Adenocarcinoma 02/2006
1	Melanoma (Melanoma, Malignant) 01/2006
1	Fibrosarcoma 06/2005
1	Corneal Neovascularization 04/2003
1	Wounds and Injuries (Trauma) 02/2003
1	Hyperglycemia 01/2003

Drug/Important Bio-Agent (IBA)

9	OxygenIBA 01/2008 - 04/2002
4	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2008 - 10/2004
3	RNA (Ribonucleic Acid)IBA 05/2008 - 04/2003
3	ErythropoietinIBA 01/2007 - 01/2006
3	Liposomes (Liposome)IBA 11/2006 - 10/2004
3	Hemoglobins (Hemoglobin)IBA 07/2005 - 05/2002
2	Free RadicalsIBA 06/2008 - 05/2004
2	Angiopoietin-2IBA 04/2007 - 04/2003
2	Glucose (Dextrose)FDA LinkGeneric 06/2005 - 03/2003
1	Bromelains (Bromelain)IBA 07/2008
1	Lactic Acid FDA LinkGeneric 05/2008
1	bevacizumab FDA Link 01/2008
1	irinotecan (Camptosar)FDA LinkGeneric 01/2008
1	NF-kappa B (NF-kB)IBA 01/2008
1	BiopolymersIBA 05/2007
1	Interleukin-12 (IL 12)IBA 01/2007
1	Type 2 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 2)IBA 09/2006
1	Vincristine (Oncovin)FDA LinkGeneric 08/2006
1	Heterotrimeric GTP-Binding Proteins (Heterotrimeric G-Proteins)IBA 05/2006
1	Drug CarriersIBA 03/2006
1	Cisplatin (Platino)FDA LinkGeneric 03/2006
1	darbepoetin alfa (Aranesp)FDA Link 02/2006
1	temozolomide (Temodar)FDA Link 01/2006
1	CamptothecinIBA 01/2006
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 12/2005
1	Urea (Carbamide)FDA LinkGeneric 11/2005
1	Superoxide DismutaseIBA 10/2005
1	ManganeseIBA 10/2005
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2005
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 05/2005
1	S-nitrosohemoglobinIBA 05/2005
1	Carbonic Anhydrases (Carbonic Anhydrase)IBA 12/2004
1	Small Interfering RNA (siRNA)IBA 11/2004
1	Recombinant ErythropoietinIBA 10/2003
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 03/2003
1	integrin-linked kinaseIBA 03/2003
1	N-((2S)-2-mercapto-1-oxo-4-(3,4,4- trimethyl- 2,5- dioxo- 1- imidazolidinyl)butyl)- L- leucyl- N,3- dimethyl-L-ValinamideIBA 02/2003
1	benzylguanidineIBA 01/2003

Therapy/Procedure

4	Drug Therapy (Chemotherapy) 02/2006 - 07/2003
2	Induced Hyperthermia (Thermotherapy) 01/2007 - 01/2006
1	Tissue Therapy (Cell Therapy) 08/2007