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Paul Dent Selected Research

sorafenib (BAY 43-9006)

10/2015Celecoxib enhances [sorafenib + sildenafil] lethality in cancer cells and reverts platinum chemotherapy resistance.
10/2015GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases.
9/2015Nexavar/Stivarga and viagra interact to kill tumor cells.
8/2015OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies.
1/2015Sorafenib/regorafenib and lapatinib interact to kill CNS tumor cells.
1/2014Multi-kinase inhibition in ovarian cancer.
10/2013Sorafenib and HDAC inhibitors synergize with TRAIL to kill tumor cells.
10/2013Sorafenib/regorafenib and phosphatidyl inositol 3 kinase/thymoma viral proto-oncogene inhibition interact to kill tumor cells.
7/2012Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling.
5/2012Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells.
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Paul Dent Research Topics

Disease

127Neoplasms (Cancer)
10/2015 - 07/2002
49Melanoma (Melanoma, Malignant)
02/2015 - 07/2002
49Leukemia
10/2013 - 01/2002
41Carcinoma (Carcinomatosis)
01/2014 - 03/2002
16Prostatic Neoplasms (Prostate Cancer)
01/2015 - 12/2003
15Infection
10/2015 - 07/2002
15Breast Neoplasms (Breast Cancer)
01/2015 - 11/2005
14Glioblastoma (Glioblastoma Multiforme)
01/2015 - 07/2003
13Glioma (Gliomas)
05/2015 - 08/2003
10Multiple Myeloma
08/2012 - 11/2002
9Ovarian Neoplasms (Ovarian Cancer)
10/2015 - 06/2002
7Pancreatic Neoplasms (Pancreatic Cancer)
09/2015 - 01/2005
7Brain Neoplasms (Brain Tumor)
07/2015 - 09/2006
7BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
08/2008 - 07/2004
6Hepatocellular Carcinoma (Hepatoma)
01/2014 - 11/2005
6Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
12/2012 - 11/2005
6Myeloid Leukemia (Leukemia, Myelocytic)
12/2010 - 01/2002
5Hematologic Neoplasms (Hematological Malignancy)
06/2007 - 11/2003
4Colonic Neoplasms (Colon Cancer)
09/2015 - 09/2007
4Colorectal Neoplasms (Colorectal Cancer)
01/2015 - 02/2005
3Necrosis
09/2015 - 07/2003
3Drug Toxicity (Drug Safety)
06/2014 - 08/2009
3Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
06/2014 - 06/2008
3Neoplasm Metastasis (Metastasis)
01/2014 - 01/2011
3B-Cell Lymphoma (Lymphoma, B Cell)
10/2013 - 05/2009
3Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell)
04/2013 - 06/2010
3Ataxia Telangiectasia (Louis Bar Syndrome)
03/2007 - 04/2003

Drug/Important Bio-Agent (IBA)

51Phosphotransferases (Kinase)IBA
09/2015 - 01/2002
41InterleukinsIBA
02/2015 - 08/2003
32Histone Deacetylase InhibitorsIBA
05/2014 - 05/2003
24sorafenib (BAY 43-9006)FDA Link
10/2015 - 10/2005
19Reactive Oxygen Species (Oxygen Radicals)IBA
09/2015 - 12/2003
18Proteins (Proteins, Gene)IBA
08/2015 - 03/2002
18vorinostat (suberoylanilide hydroxamic acid)FDA Link
05/2014 - 12/2003
177-hydroxystaurosporine (UCN 01)IBA
05/2013 - 05/2002
15CyclinsIBA
05/2014 - 09/2002
13imatinib (Gleevec)FDA Link
08/2008 - 01/2002
12Proteasome Endopeptidase Complex (Proteasome)IBA
01/2014 - 11/2003
122- (2- chloro- 4- iodophenylamino)- N- cyclopropylmethoxy- 3,4- difluorobenzamideIBA
04/2012 - 01/2002
10flavopiridolIBA
08/2012 - 03/2002
10Protein Kinases (Protein Kinase)IBA
12/2010 - 01/2002
9Messenger RNA (mRNA)IBA
02/2015 - 07/2002
8DNA (Deoxyribonucleic Acid)IBA
10/2015 - 07/2003
8lapatinib (GW572016)FDA Link
08/2015 - 11/2009
8Small Interfering RNA (siRNA)IBA
01/2015 - 11/2007
8obatoclaxIBA
10/2013 - 11/2009
8bortezomib (Velcade)FDA Link
04/2013 - 11/2003
8Interleukin-10 (Interleukin 10)IBA
05/2012 - 05/2004
7sildenafil (Viagra)FDA Link
10/2015 - 10/2010
7OSU 03012IBA
08/2015 - 08/2006
7AD 5IBA
01/2014 - 06/2010
717-(allylamino)-17-demethoxygeldanamycin (17AAG)IBA
03/2011 - 09/2003
6Protein Kinase CIBA
01/2015 - 10/2002
6Caspase 9IBA
10/2013 - 05/2002
6Histone Deacetylases (Histone Deacetylase)IBA
09/2011 - 11/2003
6adenovirus receptorIBA
01/2011 - 07/2003
6NF-kappa B (NF-kB)IBA
03/2010 - 04/2004
6Cytochromes c (Cytochrome c)IBA
08/2006 - 09/2003
6SodiumIBA
01/2006 - 09/2003
6Butyrates (Butyrate)IBA
01/2006 - 09/2003
5Type 5 Cyclic Nucleotide PhosphodiesterasesIBA
09/2015 - 10/2010
5Doxorubicin (Adriamycin)FDA LinkGeneric
09/2015 - 11/2007
5Phosphodiesterase 5 InhibitorsIBA
09/2015 - 03/2014
5Epidermal Growth Factor Receptor (EGF Receptor)IBA
06/2014 - 07/2002
5Paclitaxel (Taxol)FDA LinkGeneric
03/2014 - 05/2003
5Caspase 3 (Caspase-3)IBA
10/2010 - 03/2005
5Heat-Shock Proteins (Heat-Shock Protein)IBA
05/2010 - 09/2003
5Mitogen-Activated Protein Kinase 3IBA
11/2009 - 02/2005
4celecoxib (Celebrex)FDA Link
10/2015 - 05/2005
4Cisplatin (Platino)FDA LinkGeneric
10/2015 - 02/2010
4pemetrexed (MTA)FDA Link
01/2015 - 07/2011
4CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)IBA
06/2014 - 09/2008
4Valproic Acid (Valproate, Semisodium)FDA LinkGeneric
05/2014 - 08/2009
4AZD 6244IBA
04/2012 - 03/2008
4roscovitineIBA
11/2010 - 04/2003
4U 0126 (UO 126)IBA
11/2009 - 11/2002
4Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
12/2003 - 11/2002
3Biological Markers (Surrogate Marker)IBA
09/2015 - 05/2013
3Sirolimus (Rapamycin)FDA Link
09/2015 - 04/2003
3Folic Acid (Vitamin M)FDA LinkGeneric
01/2015 - 10/2011
3tyrosine receptor (receptor, tyrosine)IBA
06/2014 - 01/2010
3Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
06/2014 - 02/2004
3CytokinesIBA
10/2013 - 05/2004
3arsenic trioxide (Trisenox)FDA Link
10/2013 - 07/2003
3Estrogens (Estrogen)FDA Link
08/2012 - 11/2005
3Checkpoint kinase 1IBA
08/2012 - 12/2006
3Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
08/2012 - 08/2007
3carfilzomibIBA
05/2012 - 06/2010
3Peptide Initiation Factors (Initiation Factor)IBA
12/2010 - 08/2007
3Staphylococcal Protein A (A, Protein)IBA
11/2010 - 07/2008
3p38 Mitogen-Activated Protein KinasesIBA
09/2008 - 07/2002
3MAP Kinase Kinase 1IBA
09/2008 - 04/2006
3NSC 680410IBA
10/2006 - 02/2004
2PlatinumIBA
10/2015 - 09/2007
2pazopanibIBA
10/2015 - 05/2014
2Chikungunya virus infectionIBA
10/2015 - 07/2015

Therapy/Procedure

33Heterologous Transplantation (Xenotransplantation)
09/2015 - 02/2003
17Drug Therapy (Chemotherapy)
10/2015 - 06/2002
4Radiotherapy
02/2012 - 07/2003
3Therapeutics
04/2014 - 08/2010