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William A Denny Selected Research

5- (N,N- bis(2- chloroethyl)amino)- 2,4- dinitrobenzamide

4/2003Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation.

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William A Denny Research Topics

Disease

55Neoplasms (Cancer)
01/2015 - 01/2002
26Anoxia (Hypoxia)
07/2013 - 01/2003
6Carcinoma (Carcinomatosis)
04/2013 - 01/2002
5Infection
04/2015 - 12/2010
4Tuberculosis (Tuberculoses)
04/2014 - 06/2008
3Leukemia
02/2014 - 02/2012
2Genomic Instability
01/2015 - 02/2011
2Breast Neoplasms (Breast Cancer)
01/2014 - 12/2011
2Prostatic Neoplasms (Prostate Cancer)
01/2014 - 09/2012
2Ovarian Neoplasms (Ovarian Cancer)
06/2013 - 10/2012
2Lymphoma (Lymphomas)
02/2012 - 12/2008
2Glioblastoma (Glioblastoma Multiforme)
10/2011 - 02/2006
2Poisoning
01/2003 - 02/2002
2Small Cell Lung Carcinoma (Small Cell Lung Cancer)
01/2002 - 01/2002
1Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
05/2013
1Melanoma (Melanoma, Malignant)
10/2012
1Anemia
04/2012
1Weight Gain
01/2012
1Body Weight (Weight, Body)
01/2012
1Weight Loss (Weight Reduction)
01/2012
1Pancreatic Neoplasms (Pancreatic Cancer)
01/2009

Drug/Important Bio-Agent (IBA)

17ProdrugsIBA
07/2013 - 04/2003
14DNA (Deoxyribonucleic Acid)IBA
03/2012 - 03/2002
13tirapazamine (SR 4233)IBA
10/2010 - 01/2003
9Alkylating AgentsIBA
03/2012 - 03/2002
8EnzymesIBA
04/2013 - 01/2002
5CytotoxinsIBA
11/2009 - 01/2002
4carbonyl reductase (NADPH)IBA
02/2014 - 03/2010
4LigandsIBA
07/2013 - 09/2004
4cyclenIBA
07/2013 - 09/2004
4Mechlorethamine (Nitrogen Mustard)FDA Link
03/2010 - 04/2003
3OxygenIBA
07/2013 - 11/2008
3Carbon MonoxideIBA
07/2013 - 02/2004
3OPC-67683IBA
01/2012 - 12/2010
35-(1-aziridinyl)-2,4-dinitrobenzamideIBA
06/2004 - 03/2002
3Type I DNA Topoisomerases (Topoisomerase I)IBA
02/2004 - 01/2002
2pyridineIBA
04/2015 - 12/2010
2Phosphotransferases (Kinase)IBA
02/2014 - 08/2006
2Adenosine Triphosphate (ATP)IBA
02/2014 - 08/2011
2HormonesIBA
02/2014 - 01/2014
2CobaltIBA
07/2013 - 08/2011
23-amino-1,2,4-benzotriazineIBA
03/2010 - 06/2005
2PR-104AIBA
03/2010 - 07/2007
2PR-104IBA
03/2010 - 07/2007
2PA 824IBA
01/2010 - 06/2008
2quinolineIBA
11/2009 - 11/2008
2gemcitabineFDA Link
01/2009 - 07/2007
2NitrogenIBA
01/2009 - 11/2008
2Type II DNA Topoisomerases (Topoisomerase II)IBA
02/2007 - 02/2002
2trioctyl phosphine oxide (TOPO)IBA
05/2004 - 01/2003
1AcetyleneIBA
04/2015
1butyl 3-(1H-tetrazol-5-yl)oxanilate (MTB)IBA
04/2014
1Estrogens (Estrogen)FDA Link
01/2014
1Messenger RNA (mRNA)IBA
01/2014
1Prostate-Specific Antigen (Semenogelase)IBA
01/2014
1Testosterone (Sustanon)FDA Link
01/2014
1Estrone (Folliculin)FDA Link
01/2014
1Anti-Bacterial Agents (Antibiotics)IBA
08/2013
1cyclamIBA
07/2013
1Phosphatidylinositol 3-KinasesIBA
07/2013
1PIK 75IBA
06/2013
1Folic Acid (Vitamin M)FDA LinkGeneric
06/2013
15-HT1A Serotonin ReceptorIBA
05/2013
1NitroreductasesIBA
04/2013
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
10/2012
1ErythropoietinFDA Link
04/2012
1Procollagen-Proline Dioxygenase (Prolyl Hydroxylase)IBA
04/2012
1Transcription Factors (Transcription Factor)IBA
04/2012
1Amsacrine (AMSA)IBA
02/2012
1SaltsIBA
01/2012
1AdenineFDA LinkGeneric
01/2012
1IndolesIBA
01/2012
1indoleIBA
01/2012
1Urea (Carbamide)FDA LinkGeneric
01/2012
1persinIBA
12/2011
1BromidesIBA
10/2011
1PTEN Phosphohydrolase (PTEN Phosphatase)IBA
08/2011
1tensins (tensin)IBA
08/2011
1MicroRNAs (MicroRNA)IBA
02/2011
1ChromatinIBA
02/2011
1Histones (Histone)IBA
02/2011
1Histone Deacetylase InhibitorsIBA
08/2010
1Histone Deacetylases (Histone Deacetylase)IBA
08/2010
1Cadherins (E-Cadherin)IBA
08/2010
1IodidesIBA
01/2010
1AcidsIBA
01/2010
1diphenyl (biphenyl)IBA
01/2010
1Coordination ComplexesIBA
11/2009
1decitabine (5-aza-2'-deoxycytidine)FDA Link
05/2009
1Azacitidine (5 Azacytidine)FDA Link
05/2009
1stearic acid (magnesium stearate)FDA LinkGeneric
02/2009
1Chlorambucil (Leukeran)FDA Link
02/2009
1didodecyldimethylammoniumIBA
02/2009
1DNA AdductsIBA
01/2009

Therapy/Procedure

15Heterologous Transplantation (Xenotransplantation)
07/2013 - 03/2002
7Drug Therapy (Chemotherapy)
01/2015 - 01/2002
4Radiotherapy
03/2010 - 01/2004
2Therapeutics
04/2014 - 10/2012
2Aftercare (After-Treatment)
07/2007 - 08/2006
1Castration
01/2014