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Erik De Clercq Selected Research

Antiviral Agents (Antivirals)

11/2015Current treatment of hepatitis B virus infections.
7/2015Development of antiviral drugs for the treatment of hepatitis C at an accelerating pace.
6/2014Current race in the development of DAAs (direct-acting antivirals) against HCV.
11/2013Dancing with chemical formulae of antivirals: A panoramic view (Part 2).
11/2013Highlights in antiviral drug research: antivirals at the horizon.
11/2013A cutting-edge view on the current state of antiviral drug development.
10/2012Human viral diseases: what is next for antiviral drug discovery?
6/2012Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents.
7/2011The clinical potential of the acyclic (and cyclic) nucleoside phosphonates: the magic of the phosphonate bond.
1/2011The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures.
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Erik De Clercq Research Topics

Disease

75Infection
11/2015 - 04/2002
35HIV Infections (HIV Infection)
07/2015 - 01/2002
33Acquired Immunodeficiency Syndrome (AIDS)
06/2015 - 07/2002
20Neoplasms (Cancer)
09/2014 - 01/2002
13Human Influenza (Influenza)
10/2015 - 05/2003
13Poxviridae Infections
10/2010 - 07/2002
8Vaccinia
06/2009 - 07/2002
7Chronic Hepatitis B
11/2015 - 10/2003
7Papilloma (Papillomatosis)
07/2010 - 07/2002
7Smallpox (Variola)
02/2006 - 07/2002
6Carcinoma (Carcinomatosis)
08/2010 - 04/2002
5Hepatitis C
07/2015 - 06/2007
5Vesicular Stomatitis
09/2010 - 05/2002
5Contagious Ecthyma (Orf)
07/2007 - 07/2002
5Cowpox
01/2007 - 07/2002
4Hepatitis B
01/2013 - 08/2005
4Retinitis
07/2011 - 07/2002
4Non-Hodgkin Lymphoma (Lymphosarcoma)
12/2010 - 09/2005
4Osteosarcoma (Osteogenic Sarcoma)
06/2007 - 03/2005
4Monkeypox
02/2006 - 07/2002
4Molluscum Contagiosum
09/2004 - 07/2002
3Hepatocellular Carcinoma (Hepatoma)
11/2015 - 04/2006
3DNA Virus Infections
01/2013 - 09/2008
3Multiple Myeloma
12/2010 - 09/2005
3Leukemia L1210
11/2009 - 05/2007
3Diarrhea
06/2009 - 04/2006
3Cytomegalovirus Retinitis
03/2007 - 09/2004

Drug/Important Bio-Agent (IBA)

29cidofovir (Vistide)FDA Link
11/2013 - 05/2002
25Antiviral Agents (Antivirals)IBA
11/2015 - 08/2002
17tenofovir disoproxil (Viread)FDA Link
11/2015 - 11/2002
15Ribavirin (Virazole)FDA LinkGeneric
10/2015 - 01/2003
13tenofovirFDA Link
11/2013 - 10/2003
11Reverse Transcriptase InhibitorsIBA
07/2015 - 07/2002
10Acyclovir (Aciclovir)FDA LinkGeneric
11/2013 - 02/2002
9InterferonsIBA
11/2015 - 02/2003
8adefovir dipivoxil (Hepsera)FDA Link
11/2015 - 10/2003
8Protease Inhibitors (Protease Inhibitor)IBA
07/2015 - 11/2002
8emtricitabine (Emtriva)FDA Link
01/2013 - 11/2002
8Phosphonic Acids (Phosphonates)IBA
07/2011 - 10/2003
8JM 3100FDA Link
12/2010 - 07/2002
7Lamivudine (3TC)FDA Link
11/2015 - 11/2002
7DNA (Deoxyribonucleic Acid)IBA
07/2015 - 01/2003
7RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
06/2015 - 01/2002
7Anti-HIV Agents (AIDS Drugs)IBA
02/2013 - 08/2005
7Rilpivirine (TMC-278)IBA
01/2013 - 01/2008
7adefovirIBA
01/2013 - 10/2003
6Amantadine (Aman)FDA LinkGeneric
10/2015 - 06/2004
6RimantadineFDA LinkGeneric
10/2015 - 05/2003
6Neuraminidase (Sialidase)IBA
11/2013 - 06/2004
6efavirenz (Sustiva)FDA Link
01/2013 - 11/2002
6Ganciclovir (Cytovene)FDA LinkGeneric
01/2011 - 01/2004
6Thymidine KinaseIBA
06/2007 - 05/2002
5RNA (Ribonucleic Acid)IBA
06/2015 - 05/2005
5JTK 303IBA
11/2013 - 01/2008
5Oseltamivir (Tamiflu)FDA Link
11/2013 - 06/2004
5Zanamivir (Relenza)FDA Link
11/2013 - 06/2004
5ProdrugsIBA
07/2011 - 01/2006
5Idoxuridine (Stoxil)FDA LinkGeneric
01/2009 - 09/2002
5CytosineIBA
07/2007 - 07/2002
46-fluoro-3-hydroxy-2-pyrazinecarboxamideIBA
01/2015 - 01/2008
4peramivirIBA
11/2013 - 01/2008
49- (3- hydroxy- 2- phosphonylmethoxypropyl)adenineIBA
07/2011 - 01/2005
4Zidovudine (Retrovir)FDA LinkGeneric
01/2010 - 11/2002
4Stavudine (Zerit)FDA LinkGeneric
09/2009 - 11/2002
4Carbon MonoxideIBA
09/2009 - 02/2003
4abacavir (Ziagen)FDA Link
09/2009 - 11/2002
4AdenosylhomocysteinaseIBA
07/2009 - 01/2003
4Interferon-alpha (Interferon Alfa)FDA Link
01/2008 - 01/2003
4AdenineFDA LinkGeneric
10/2007 - 01/2005
4FoscarnetFDA LinkGeneric
12/2006 - 09/2002
4Mannose (D-Mannose)IBA
02/2006 - 10/2004
3entecavirFDA Link
11/2015 - 06/2010
3telbivudineFDA Link
11/2015 - 06/2010
3N- (3- amino- 1- (cyclobutylmethyl)- 2,3- dioxopropyl)- 3- (2- ((((1,1- dimethylethyl)amino)carbonyl)amino)- 3,3- dimethyl- 1- oxobutyl)- 6,6- dimethyl- 3- azabicyclo(3.1.0)hexan- 2- carboxamideIBA
07/2015 - 09/2008
3telaprevirIBA
07/2015 - 09/2008
3brivudine (brivudin)IBA
07/2015 - 06/2004
3pyrimidineIBA
06/2015 - 05/2003
3CytotoxinsIBA
04/2014 - 06/2009
3darunavir (Prezista)FDA Link
11/2013 - 09/2009
3cidofovir hexadecyloxypropyl esterIBA
11/2013 - 11/2013
3MK 0518FDA Link
11/2013 - 09/2009
3TruvadaFDA Link
11/2013 - 07/2007
3atazanavir (Reyataz)FDA Link
07/2012 - 06/2004
39- (3- hydroxy- 2- phosphonomethoxypropyl)- 2,6- diaminopurineIBA
10/2010 - 01/2005
3EstersIBA
11/2009 - 07/2007
3Delavirdine (Rescriptor)FDA Link
09/2009 - 11/2002
3Nelfinavir (Viracept)FDA Link
09/2009 - 11/2002
3Saquinavir (Invirase)FDA Link
09/2009 - 11/2002
3lopinavir (Kaletra)FDA Link
09/2009 - 11/2002
3Didanosine (Videx)FDA LinkGeneric
09/2009 - 11/2002
3Indinavir (Crixivan)FDA Link
09/2009 - 11/2002
3Zalcitabine (Hivid)FDA Link
09/2009 - 11/2002
3Nevirapine (Viramune)FDA Link
09/2009 - 11/2002
3Ritonavir (Norvir)FDA Link
09/2009 - 11/2002
3amprenavir (141W94)FDA Link
09/2009 - 11/2002
3DEBIO-025IBA
09/2008 - 04/2006

Therapy/Procedure

8Drug Therapy (Chemotherapy)
03/2015 - 04/2002
4Transplantation (Transplant Recipients)
06/2009 - 01/2005
3Therapeutics
06/2015 - 12/2008
3Highly Active Antiretroviral Therapy (HAART)
10/2010 - 01/2005