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Ted M Dawson Selected Research

Parkinson Disease (Parkinson's Disease)

12/2015TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF.
1/2015Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity.
12/2014LRRK2 pathobiology in Parkinson's disease.
12/2014Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain.
11/2014Early-onset Parkinson's disease due to PINK1 p.Q456X mutation--clinical and functional study.
11/2014Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration.
5/2014A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit.
4/2014Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.
4/2014Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.
1/2014The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease.
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Ted M Dawson Research Topics

Disease

78Parkinson Disease (Parkinson's Disease)
12/2015 - 06/2002
13Neurodegenerative Diseases (Neurodegenerative Disease)
01/2015 - 06/2002
8Parkinsonian Disorders (Parkinsonism)
05/2014 - 11/2003
7Stroke (Strokes)
05/2014 - 04/2002
4Ischemia
11/2012 - 10/2003
3Dementia (Dementias)
01/2015 - 06/2008
3Reperfusion Injury
01/2009 - 07/2002
3Neuroblastoma
07/2005 - 04/2003
2Gaucher Disease (Gaucher's Disease)
01/2015 - 07/2011
2Movement Disorders (Movement Disorder)
01/2014 - 11/2003
2Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
06/2011 - 07/2010
2Brain Ischemia (Cerebral Ischemia)
07/2010 - 05/2010
2Lewy Body Disease (Lewy Body Dementia)
09/2009 - 06/2006
2Necrosis
08/2009 - 10/2002
2Alzheimer Disease (Alzheimer's Disease)
06/2008 - 01/2004
1Memory Disorders (Memory Loss)
09/2014
1Tremor (Tremors)
05/2014
1Disease Progression
05/2014
1Nerve Degeneration
04/2014
1Epilepsy (Aura)
01/2013
1Rodent Diseases
10/2011
1Nervous System Diseases (Neurological Disorders)
06/2011
1Hypersensitivity (Allergy)
12/2009
1Tuberous Sclerosis (Bourneville's Disease)
06/2008
1Ataxia Telangiectasia (Louis Bar Syndrome)
06/2007
1Male Infertility (Male Sterility)
05/2006
1Inflammation
07/2005
1Genomic Instability
12/2004
1Anoxia (Hypoxia)
09/2004
1Brain Injuries (Brain Injury)
09/2004
1Melanoma (Melanoma, Malignant)
05/2004

Drug/Important Bio-Agent (IBA)

27Leucine (L-Leucine)FDA Link
12/2014 - 11/2005
23Phosphotransferases (Kinase)IBA
12/2014 - 11/2005
13alpha-SynucleinIBA
06/2010 - 06/2002
12Dopamine (Intropin)FDA LinkGeneric
12/2015 - 06/2003
12UbiquitinIBA
10/2013 - 01/2003
10Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
12/2014 - 05/2004
7Poly Adenosine Diphosphate RiboseIBA
06/2011 - 09/2004
61- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
01/2014 - 06/2003
6Glutamic Acid (Glutamate)FDA Link
11/2012 - 07/2002
5Proteins (Proteins, Gene)IBA
12/2005 - 01/2003
4SynucleinsIBA
12/2015 - 01/2011
4N-Methylaspartate (NMDA)IBA
11/2012 - 08/2004
4Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2006 - 10/2003
4Proteasome Endopeptidase Complex (Proteasome)IBA
02/2005 - 01/2003
3PTEN-induced putative kinaseIBA
11/2014 - 05/2006
3Apoptosis Inducing FactorIBA
07/2010 - 06/2003
3DNA (Deoxyribonucleic Acid)IBA
05/2010 - 06/2007
2Glucosylceramidase (Glucocerebrosidase)IBA
01/2015 - 07/2011
2Dynamins (Dynamin)IBA
12/2014 - 04/2014
2Adenosine Triphosphatases (ATPase)IBA
09/2014 - 10/2003
2GTP Phosphohydrolases (GTPases)IBA
04/2014 - 10/2012
2MicroRNAs (MicroRNA)IBA
01/2013 - 10/2011
2N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
06/2011 - 08/2004
2Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
07/2010 - 04/2002
2EnzymesIBA
05/2010 - 10/2003
2AntibodiesIBA
09/2009 - 07/2005
2Detergents (Detergent)IBA
06/2008 - 04/2004
2Messenger RNA (mRNA)IBA
01/2007 - 07/2005
2Carbon MonoxideIBA
04/2006 - 07/2005
1Ciliary Neurotrophic Factor (CNTF)IBA
12/2015
1Ciliary Neurotrophic Factor ReceptorIBA
12/2015
1Glutamate Receptors (Glutamate Receptor)IBA
09/2014
1alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA
09/2014
1coenzyme Q10 (CoQ10)IBA
05/2014
1Alanine (L-Alanine)FDA Link
04/2014
1ribosomal protein S15IBA
04/2014
1Threonine (L-Threonine)FDA Link
04/2014
1Mitochondrial Proteins (Mitochondrial Protein)IBA
01/2014
1Tyrosine (L-Tyrosine)FDA Link
01/2014
14- methyl- N- (3- (4- methylimidazol- 1- yl)- 5- (trifluoromethyl)phenyl)- 3- ((4- pyridin- 3- ylpyrimidin- 2- yl)amino)benzamide (nilotinib)FDA Link
01/2014
1CalciumIBA
11/2012
1Ionotropic Glutamate ReceptorsIBA
11/2012
1IronIBA
09/2011
1PolymersIBA
06/2011
1OxygenIBA
07/2010
1LatexIBA
07/2010
1endonuclease GIBA
07/2010
1Glucose (Dextrose)FDA LinkGeneric
07/2010
1tensins (tensin)IBA
01/2010
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
10/2009
1Lysosomal-Associated Membrane Protein 2IBA
09/2009
1Staphylococcal Protein A (A, Protein)IBA
03/2009
1tuberous sclerosis complex 2 protein (tuberin)IBA
06/2008
1neuromelaninIBA
04/2008
1Lysine (L-Lysine)FDA Link
02/2008
1Protein Kinases (Protein Kinase)IBA
06/2007
1Adenosine Diphosphate (ADP)IBA
06/2007
1Guanosine Triphosphate (GTP)IBA
01/2007
1Carrier Proteins (Binding Protein)IBA
06/2006
1Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)IBA
06/2006
1Selegiline (E250)FDA LinkGeneric
03/2006
1Croton OilIBA
07/2005
1Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
07/2005
1NG-Nitroarginine Methyl Ester (L-NAME)IBA
07/2005
1mu Opioid Receptors (mu Opioid Receptor)IBA
07/2005
1Morphine (MS Contin)FDA LinkGeneric
07/2005
1Interferon-gamma (Interferon, gamma)IBA
05/2004
1CytokinesIBA
05/2004

Therapy/Procedure

1Lasers (Laser)
07/2010