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Giuseppe D'Alessio Selected Research

Ribonucleases (Ribonuclease)

6/2012Comparison of preclinical cardiotoxic effects of different ErbB2 inhibitors.
4/2011A novel ErbB2 epitope targeted by human antitumor immunoagents.
6/2008A novel human antitumor dimeric immunoRNase.
7/2004A fully human antitumor immunoRNase selective for ErbB-2-positive carcinomas.
6/2003Antineoplastic ribonucleases selectively kill thyroid carcinoma cells via caspase-mediated induction of apoptosis.
12/2002Engineering the refolding pathway and the quaternary structure of seminal ribonuclease by newly introduced disulfide bridges.
4/2002A new RNase-based immunoconjugate selectively cytotoxic for ErbB2-overexpressing cells.

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Giuseppe D'Alessio Research Topics

Disease

12Neoplasms (Cancer)
07/2012 - 04/2002
5Carcinoma (Carcinomatosis)
07/2012 - 07/2004
4Breast Neoplasms (Breast Cancer)
07/2012 - 10/2008
1Prostatic Neoplasms (Prostate Cancer)
07/2012
1Bone Diseases (Bone Disease)
06/2010
1Rheumatic Diseases (Rheumatism)
06/2010
1Osteosarcoma (Osteogenic Sarcoma)
06/2010
1Fibrosis (Cirrhosis)
09/2009
1Thyroid Neoplasms (Thyroid Cancer)
06/2003

Drug/Important Bio-Agent (IBA)

7Ribonucleases (Ribonuclease)IBA
06/2012 - 04/2002
6trastuzumab (Herceptin)FDA Link
07/2012 - 10/2008
3Erb-hcAbIBA
07/2012 - 11/2005
3AntibodiesIBA
07/2012 - 03/2009
3Immunoglobulin G (IgG)IBA
06/2012 - 11/2005
3ribonuclease SPLIBA
01/2011 - 12/2002
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
07/2012 - 03/2009
2Immunoconjugates (Immunoconjugate)IBA
06/2012 - 04/2011
2AntigensIBA
06/2008 - 04/2002
2Single-Chain AntibodiesIBA
07/2004 - 04/2002
1HormonesIBA
07/2012
1Androgen Receptors (Androgen Receptor)IBA
07/2012
1EpitopesIBA
04/2011
1Protein Isoforms (Isoforms)IBA
01/2011
1Interleukin-1 (Interleukin 1)IBA
06/2010
1CytokinesIBA
06/2010
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2010
1Interleukin-6 (Interleukin 6)IBA
06/2010
1CollagenIBA
09/2009
1Antineoplastic Agents (Antineoplastics)IBA
03/2009
1Immunotoxins (Immunotoxin)IBA
06/2008
1ERB-hRNaseIBA
06/2008
1erbB-2 Receptor (Receptor, erbB 2)IBA
07/2004
1z-Val-Ala-Asp(Ome)-fluoromethylketoneIBA
06/2003
1Protein-Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
06/2003
1Pancreatic Ribonuclease (Ribonuclease A)IBA
06/2003
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
06/2003

Therapy/Procedure

5Immunotherapy
07/2012 - 11/2005
1Therapeutics
06/2002