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D Cunningham Selected Research

Fluorouracil (Carac)

12/2011Efficacy of capecitabine versus 5-fluorouracil in colorectal and gastric cancers: a meta-analysis of individual data from 6171 patients.
9/2009Meta-analysis of the REAL-2 and ML17032 trials: evaluating capecitabine-based combination chemotherapy and infused 5-fluorouracil-based combination chemotherapy for the treatment of advanced oesophago-gastric cancer.
10/2008Capecitabine plus oxaliplatin (XELOX) versus 5-fluorouracil/folinic acid plus oxaliplatin (FOLFOX-4) as second-line therapy in metastatic colorectal cancer: a randomized phase III noninferiority study.
3/2006Phase III trial of 5-fluorouracil and leucovorin plus either 3H1 anti-idiotype monoclonal antibody or placebo in patients with advanced colorectal cancer.
6/2005Report of two protocol planned interim analyses in a randomised multicentre phase III study comparing capecitabine with fluorouracil and oxaliplatin with cisplatin in patients with advanced oesophagogastric cancer receiving ECF.
4/2005A randomised comparison between 6 months of bolus fluorouracil/leucovorin and 12 weeks of protracted venous infusion fluorouracil as adjuvant treatment in colorectal cancer.
3/2004Oral capecitabine vs intravenous 5-fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomised, phase III trials.
1/2004Phase II study of irinotecan and 5-fluorouracil/leucovorin in patients with primary refractory or relapsed advanced oesophageal and gastric carcinoma.
8/2003A phase I/II study of oral uracil/tegafur (UFT), leucovorin and irinotecan in patients with advanced colorectal cancer.
6/2003Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
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D Cunningham Research Topics

Disease

31Colorectal Neoplasms (Colorectal Cancer)
05/2012 - 01/2001
12Neoplasms (Cancer)
01/2011 - 09/2001
6Stomach Neoplasms (Stomach Cancer)
12/2011 - 10/2002
6Neutropenia
10/2008 - 03/2002
6Pancreatic Neoplasms (Pancreatic Cancer)
07/2008 - 03/2002
5Neoplasm Metastasis (Metastasis)
05/2012 - 01/2004
5Adenocarcinoma
10/2010 - 03/2001
4Gastrointestinal Neoplasms (Gastrointestinal Cancer)
12/2011 - 02/2001
4Non-Hodgkin Lymphoma (Lymphosarcoma)
03/2006 - 01/2001
3Rectal Neoplasms (Rectal Cancer)
02/2006 - 04/2003
3Stomatitis
04/2005 - 05/2003
3Carcinoma (Carcinomatosis)
01/2004 - 04/2002
2Hypertension (High Blood Pressure)
05/2012 - 11/2009
2Disease Progression
10/2008 - 04/2003
2Lethargy
09/2008 - 04/2005
2Nausea
07/2008 - 04/2005
2Vomiting
07/2008 - 04/2005
2Hodgkin Disease (Hodgkin's Disease)
07/2008 - 03/2001
2Weight Loss (Weight Reduction)
01/2007 - 07/2004
2Lymphoma (Lymphomas)
04/2005 - 08/2004
2Alopecia (Baldness)
04/2005 - 06/2003
2Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
08/2004 - 04/2000
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
11/2002 - 04/2002
2Infection
05/2001 - 01/2000
2B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
01/2001 - 01/2000
1Dehydration (Water Stress)
01/2011
1Liver Diseases (Liver Disease)
01/2010
1Proteinuria
11/2009
1Hemorrhage
11/2009
1Thromboembolism
11/2009
1Diarrhea
10/2008
1Thrombocytopenia (Thrombopenia)
07/2008
1Second Primary Neoplasms (Neoplasms, Second)
07/2008
1Renal Tubular Acidosis (Distal Renal Tubular Acidosis)
04/2007
1Raynaud Disease (Raynaud's Disease)
05/2005
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell)
01/2003
1Colonic Neoplasms (Colon Cancer)
01/2003

Drug/Important Bio-Agent (IBA)

23Fluorouracil (Carac)FDA LinkGeneric
12/2011 - 03/2001
15capecitabine (Xeloda)FDA Link
05/2012 - 08/2003
13oxaliplatin (Eloxatin)FDA LinkGeneric
05/2012 - 05/2001
9irinotecan (Camptosar)FDA LinkGeneric
10/2008 - 05/2001
9Leucovorin (Folinic Acid)FDA Link
10/2008 - 05/2001
8Cisplatin (Platino)FDA LinkGeneric
11/2010 - 12/2001
4bevacizumabFDA Link
05/2012 - 10/2009
4Mitomycin (Mitomycin-C)FDA LinkGeneric
05/2003 - 04/2002
3Epirubicin (Ellence)FDA LinkGeneric
11/2010 - 04/2002
3Epidermal Growth Factor Receptor (EGF Receptor)IBA
09/2008 - 10/2004
3gemcitabineFDA Link
07/2008 - 04/2005
2matuzumabIBA
11/2010 - 09/2008
2Carcinoembryonic AntigenIBA
05/2010 - 01/2004
2XELOXIBA
11/2009 - 10/2008
2thymidine 5'-triphosphate (TTP)IBA
07/2008 - 03/2004
2cetuximab (Erbitux)FDA Link
01/2007 - 10/2004
2Dexamethasone (Maxidex)FDA LinkGeneric
08/2004 - 12/2001
2Thymidylate SynthaseIBA
03/2002 - 11/2001
2Glycine (Aminoacetic Acid)FDA LinkGeneric
09/2001 - 02/2001
2Codon (Codons)IBA
09/2001 - 02/2001
2Valine (L-Valine)FDA Link
09/2001 - 02/2001
2rituximab (Mabthera)FDA Link
04/2000 - 01/2000
1Biological Markers (Surrogate Marker)IBA
05/2012
1Dihydrotachysterol (AT 10)IBA
07/2008
1Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
07/2008
1N,N'- bis(pyridoxal- 5- phosphate)ethylenediamine- N,N'- diacetic acid (mangafodipir)FDA Link
07/2008
1erlotinib (CP 358,774)FDA Link
06/2007
1Platinum Compounds (Compounds, Platinum)IBA
06/2007
1gefitinib (Iressa)FDA Link
04/2007
1Granulocyte Colony-Stimulating Factor (G-CSF)IBA
03/2006
1PMitCEBO protocolIBA
03/2006
1Monoclonal AntibodiesIBA
06/2005
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
06/2005
1MethylprednisoloneFDA LinkGeneric
04/2005
1Flavin-Adenine Dinucleotide (FAD)IBA
08/2004
1fludarabineIBA
08/2004
1Doxorubicin (Adriamycin)FDA LinkGeneric
08/2004
1Alkaline PhosphataseIBA
07/2004
1PlatinumIBA
01/2004
1TegafurIBA
08/2003
1UracilIBA
08/2003
1Urea (Carbamide)FDA LinkGeneric
05/2003
1Alanine Transaminase (SGPT)IBA
05/2003
1Carboplatin (JM8)FDA LinkGeneric
05/2003
1N 30IBA
04/2003
1Vitamin DFDA LinkGeneric
03/2002
1seocalcitolIBA
03/2002
1raltitrexed (D 1694)IBA
03/2002
1CytotoxinsIBA
03/2002

Therapy/Procedure

38Drug Therapy (Chemotherapy)
05/2012 - 01/2001
4Radiotherapy
01/2007 - 03/2001
3Combination Drug Therapy (Combination Chemotherapy)
09/2009 - 01/2003
2Neoadjuvant Therapy
01/2010 - 02/2006
1Adjuvant Chemotherapy
10/2010
1Transplants (Transplant)
07/2008
1Stem Cell Transplantation
07/2008
1Combined Modality Therapy
04/2007
1Intradermal Injections
01/2004
1Intravenous Infusions
06/2003
1Immunotherapy
01/2003
1Biological Therapy
05/2002
1Heterologous Transplantation (Xenotransplantation)
03/2002
1Palliative Care (Palliative Medicine)
02/2002