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M D Culler Selected Research

Somatostatin Receptors (Somatostatin Receptor)

5/2008Effects of selective somatostatin analogs and cortistatin on cell viability in cultured human non-functioning pituitary adenomas.
3/2007Effects of somatostatin-14 and the receptor-specific somatostatin analogs on chromogranin A and alpha-subunit (alpha-SU) release from "clinically nonfunctioning" pituitary adenoma cells incubated in vitro.
1/2006The effect of selective sst1, sst2, sst5 somatostatin receptors agonists, a somatostatin/dopamine (SST/DA) chimera and bromocriptine on the "clinically non-functioning" pituitary adenomas in vitro.
10/2005Dopamine receptor subtype 2 and somatostatin receptor subtype 5 expression influences somatostatin analogs effects on human somatotroph pituitary adenomas in vitro.
7/2005Efficacy of chimeric molecules directed towards multiple somatostatin and dopamine receptors on inhibition of GH and prolactin secretion from GH-secreting pituitary adenomas classified as partially responsive to somatostatin analog therapy.
1/2005BIM-23A760, a chimeric molecule directed towards somatostatin and dopamine receptors, vs universal somatostatin receptors ligands in GH-secreting pituitary adenomas partial responders to octreotide.
3/2004Expression and function of somatostatin receptor subtype 1 in human growth hormone secreting pituitary tumors deriving from patients partially responsive or resistant to long-term treatment with somatostatin analogs.
6/2003An in vivo OctreoScan-negative adrenal pheochromocytoma expresses somatostatin receptors and responds to somatostatin analogs treatment in vitro.
1/2003Distribution and functionality of the somatostatin receptor subtypes in acromegaly.
5/2002Somatostatin, but not somatostatin receptor subtypes 2 and 5 selective agonists, inhibits calcitonin secretion and gene expression in the human medullary thyroid carcinoma cell line, TT.
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M D Culler Research Topics

Disease

13Neoplasms (Cancer)
11/2011 - 02/2000
8Pituitary Neoplasms (Pituitary Adenoma)
11/2011 - 07/2001
8Adenoma (Adenomas)
05/2008 - 02/2000
4Growth Hormone-Secreting Pituitary Adenoma
10/2005 - 12/2002
4Acromegaly
03/2004 - 02/2000
2Prostatic Neoplasms (Prostate Cancer)
02/2014 - 12/2010
2Prolactinoma (Prolactinomas)
10/2005 - 01/2001
2Thyroid Neoplasms (Thyroid Cancer)
05/2002 - 05/2001
1Neuroendocrine Tumors (Neuroendocrine Tumor)
11/2011
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
12/2010
1Lung Neoplasms (Lung Cancer)
12/2010
1Weight Gain
09/2005
1Pheochromocytoma
06/2003
1Hypertension (High Blood Pressure)
06/2003
1Kaposi Sarcoma (Kaposi's Sarcoma)
04/2003
1Neuroblastoma
09/2000

Drug/Important Bio-Agent (IBA)

18Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
02/2014 - 02/2000
15Somatostatin Receptors (Somatostatin Receptor)IBA
05/2008 - 02/2000
7Dopamine (Intropin)FDA LinkGeneric
11/2011 - 12/2002
7Growth Hormone (Somatotropin)IBA
05/2008 - 01/2001
6ProlactinIBA
11/2011 - 12/2002
6Octreotide (Sandostatin)FDA LinkGeneric
07/2005 - 02/2000
6Messenger RNA (mRNA)IBA
07/2005 - 02/2000
5somatostatin receptor type 1IBA
03/2004 - 02/2000
4Dopamine Receptors (Dopamine Receptor)IBA
12/2010 - 01/2005
4lanreotide (Somatuline)FDA Link
07/2005 - 07/2001
3LigandsIBA
12/2010 - 01/2005
3RNA (Ribonucleic Acid)IBA
05/2008 - 02/2000
3BIM-23244IBA
10/2005 - 01/2001
3BIM 23268IBA
07/2001 - 02/2000
2BIM 23120IBA
03/2007 - 10/2005
2BIM 23206IBA
03/2007 - 10/2005
2Chromogranin AIBA
03/2007 - 06/2003
2GhrelinIBA
09/2005 - 12/2004
2BIM 23A760IBA
07/2005 - 01/2005
2BIM 23197IBA
01/2001 - 02/2000
2harpin (messenger)IBA
01/2001 - 02/2000
1Adrenocorticotropic Hormone (ACTH)FDA Link
11/2011
1Carbon MonoxideIBA
12/2010
1PeptidesIBA
05/2008
1cortistatinIBA
05/2008
1BIM 23926IBA
03/2007
1GonadotropinsIBA
03/2007
1Pituitary HormonesIBA
01/2006
1ParaffinIBA
01/2006
1Collagenases (Collagenase)FDA Link
01/2006
1Bromocriptine (Parlodel)FDA LinkGeneric
01/2006
1Human Growth Hormone (Saizen)FDA LinkGeneric
03/2004
1pentetreotide (OctreoScan)FDA Link
06/2003
1Vanilmandelic Acid (Vanillylmandelic Acid)IBA
06/2003
1Protein Kinases (Protein Kinase)IBA
04/2003
1Doxorubicin (Adriamycin)FDA LinkGeneric
04/2003
1Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
04/2003
1GlucuronidaseIBA
12/2002
1Calcitonin (Calcitonin, Eel)FDA LinkGeneric
05/2002
1somatostatin receptor 2IBA
07/2001
1BIM 23190IBA
07/2001
1OxidoreductasesIBA
01/2001
1tranilast (N 5')IBA
01/2001
1somatostatin receptor 5IBA
01/2001
1Phosphotransferases (Kinase)IBA
09/2000
1HormonesIBA
02/2000

Therapy/Procedure

1Heterologous Transplantation (Xenotransplantation)
04/2003