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Douglas B Cines Selected Research

Thrombocytopenia (Thrombopenia)

6/2015Can immune thrombocytopenia be cured with medical therapy?
4/2015Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice.
1/2015Atomic description of the immune complex involved in heparin-induced thrombocytopenia.
4/2014Pathogenesis of immune thrombocytopenia.
11/2013Distinct specificity and single-molecule kinetics characterize the interaction of pathogenic and non-pathogenic antibodies against platelet factor 4-heparin complexes with platelet factor 4.
5/2013Novel diagnostic assays for heparin-induced thrombocytopenia.
4/2013Standardization of bleeding assessment in immune thrombocytopenia: report from the International Working Group.
1/2013Innate and adaptive immunity in immune thrombocytopenia.
11/2012Antigen and substrate withdrawal in the management of autoimmune thrombotic disorders.
8/2012How I treat immune thrombocytopenia: the choice between splenectomy or a medical therapy as a second-line treatment.
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Douglas B Cines Research Topics

Disease

35Thrombocytopenia (Thrombopenia)
06/2015 - 02/2002
21Thrombosis (Thrombus)
09/2015 - 02/2002
12Hemorrhage
04/2015 - 08/2003
11Brain Injuries (Brain Injury)
04/2015 - 09/2004
10Inflammation
06/2015 - 05/2003
9Stroke (Strokes)
02/2014 - 09/2006
8Ischemia
02/2014 - 02/2008
8Hypotension (Low Blood Pressure)
07/2012 - 09/2008
7Infection
04/2014 - 12/2003
7Anoxia (Hypoxia)
02/2014 - 10/2005
6Acute Lung Injury
11/2011 - 10/2006
5Thrombocytopenic Purpura (Thrombopenic Purpura)
12/2009 - 06/2007
5Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
10/2005 - 08/2002
4Neoplasms (Cancer)
09/2013 - 02/2006
4Hypercapnia
11/2011 - 09/2008
3Vascular System Injuries
05/2015 - 06/2004
3Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain)
07/2010 - 10/2005
3Lung Injury
06/2010 - 05/2003
3Neoplasm Metastasis (Metastasis)
03/2007 - 02/2006
3Pathologic Processes
10/2006 - 10/2002
2Thrombotic Thrombocytopenic Purpura
05/2015 - 11/2012
2Brain Hypoxia (Cerebral Hypoxia)
02/2014 - 03/2009
2Intracranial Hemorrhages (Intracranial Hemorrhage)
11/2013 - 04/2010
2Pulmonary Edema
07/2011 - 10/2006
2Pneumonia (Pneumonitis)
12/2010 - 05/2003
2Brain Ischemia (Cerebral Ischemia)
08/2010 - 10/2005
2Purpura
12/2009 - 11/2008
2Brain Edema (Cerebral Edema)
06/2007 - 09/2006
1Myelodysplastic Syndromes (Myelodysplastic Syndrome)
09/2015
1Cerebral Hemorrhage
04/2015
1Genetic Predisposition to Disease (Genetic Predisposition)
04/2014
1Thrombotic Microangiopathies
09/2013
1Pancreatic Neoplasms (Pancreatic Cancer)
09/2013
1Autoimmune Hemolytic Anemia (Cold Agglutinin Disease)
01/2013
1Systemic Lupus Erythematosus (Libman-Sacks Disease)
01/2013
1Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome)
11/2012
1Sepsis (Septicemia)
10/2012

Drug/Important Bio-Agent (IBA)

21Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
04/2015 - 10/2002
20Plasminogen Activators (Plasminogen Activator)IBA
04/2015 - 10/2002
20Heparin (Liquaemin)FDA LinkGeneric
01/2015 - 02/2002
19Inosine Triphosphate (ITP)IBA
06/2015 - 08/2002
15Tissue Plasminogen Activator (Alteplase)FDA Link
04/2015 - 09/2004
12AntibodiesIBA
01/2015 - 02/2002
12Platelet Factor 4IBA
01/2015 - 02/2002
6AutoantibodiesIBA
11/2012 - 08/2002
6FibrinIBA
05/2012 - 08/2003
5N-Methylaspartate (NMDA)IBA
11/2013 - 05/2005
4Phosphotransferases (Kinase)IBA
11/2011 - 03/2009
4Urokinase Plasminogen Activator ReceptorsIBA
02/2009 - 05/2003
3von Willebrand FactorIBA
05/2015 - 12/2011
3Immunoglobulin G (IgG)IBA
01/2015 - 02/2007
3GlycosaminoglycansIBA
01/2015 - 06/2004
3AntigensIBA
11/2012 - 02/2007
3U 0126 (UO 126)IBA
07/2012 - 09/2008
3Protein Kinases (Protein Kinase)IBA
11/2011 - 03/2009
3alpha-DefensinsIBA
05/2010 - 08/2004
3Glycoproteins (Glycoprotein)IBA
09/2007 - 12/2002
3Proteins (Proteins, Gene)IBA
03/2007 - 08/2003
2romiplostimFDA Link
09/2015 - 11/2008
2rituximab (Mabthera)FDA Link
06/2015 - 08/2012
2Thromboplastin (Tissue Factor)IBA
04/2015 - 02/2008
2PlasminogenIBA
04/2015 - 05/2003
2Antigen-Antibody Complex (Immune Complex)IBA
01/2015 - 01/2009
2ChloraloseIBA
02/2014 - 10/2005
2p38 Mitogen-Activated Protein KinasesIBA
11/2013 - 07/2010
2ThrombomodulinIBA
10/2012 - 08/2009
2Thrombopoietin ReceptorsIBA
08/2012 - 11/2008
2Glucagon (Glukagon)FDA Link
07/2012 - 03/2011
2Dinoprostone (PGE2)FDA Link
07/2012 - 11/2008
2Glutamic Acid (Glutamate)FDA Link
07/2012 - 03/2011
2ThrombinFDA Link
05/2012 - 02/2007
2Adenosine Triphosphate (ATP)IBA
03/2012 - 02/2011
2KATP ChannelsIBA
03/2012 - 02/2011
2Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
11/2011 - 03/2011
2PeptidesIBA
07/2010 - 08/2004
2Nitric Oxide (Nitrogen Monoxide)FDA Link
11/2008 - 09/2004
2FibrinolysinFDA Link
02/2008 - 05/2003
2Serine Proteases (Serine Protease)IBA
10/2006 - 09/2004
2abciximab (ReoPro)FDA Link
04/2004 - 03/2004
1Dexamethasone (Maxidex)FDA LinkGeneric
06/2015
1Prednisone (Sone)FDA LinkGeneric
06/2015
1thymidine 5'-triphosphate (TTP)IBA
05/2015
1Biological Markers (Surrogate Marker)IBA
09/2014
1Endothelin-1 (Endothelin 1)IBA
02/2014
1Endothelins (Endothelin)IBA
02/2014
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
11/2013
1Complement System Proteins (Complement)IBA
09/2013
1Transcription Factors (Transcription Factor)IBA
09/2013
1gemcitabineFDA Link
09/2013
1PolymersIBA
08/2013
1LigandsIBA
08/2013
1Recombinant Fusion ProteinsIBA
08/2013
1SmogIBA
04/2013
1Monoclonal AntibodiesIBA
08/2012
1EpitopesIBA
08/2012
1Epoprostenol (Prostacyclin)FDA LinkGeneric
07/2012

Therapy/Procedure

4Splenectomy
08/2012 - 01/2004
2Thrombolytic Therapy
07/2010 - 08/2009
1Hematopoietic Stem Cell Transplantation
09/2013
1Drug Therapy (Chemotherapy)
08/2013