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Konstantin Christov Selected Research

Retinoids

7/2015Retinoids induce cellular senescence in breast cancer cells by RAR-β dependent and independent pathways: Potential clinical implications (Review).
4/2013Bexarotene induces cellular senescence in MMTV-Neu mouse model of mammary carcinogenesis.
9/2011Early in vitro passages of breast cancer cells are differentially susceptible to retinoids and differentially express RARβ isoforms.
1/2010p27(Kip1) deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic process.
3/2009The novel RARbeta isoform (beta5) is a potential target of retinoids in breast cancer.
6/2006Efficacy of new retinoids in the prevention of mammary cancers and correlations with short-term biomarkers.
5/2005Retinoids suppress premalignant MCF10AT but not malignant MCF10CA1a breast epithelial cells in vivo. Role of retinoic acid receptor beta2 expression.
2/2005Identification of novel RARbeta2 transcript variants with short 5'-UTRs in normal and cancerous breast epithelial cells.
12/2004A novel RARbeta isoform directed by a distinct promoter P3 and mediated by retinoic acid in breast cancer cells.
10/2004Breast cancer progression in MCF10A series of cell lines is associated with alterations in retinoic acid and retinoid X receptors and with differential response to retinoids.

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Konstantin Christov Research Topics

Disease

24Neoplasms (Cancer)
01/2014 - 11/2002
16Breast Neoplasms (Breast Cancer)
07/2015 - 02/2003
5Body Weight (Weight, Body)
04/2013 - 02/2003
5Carcinoma (Carcinomatosis)
09/2011 - 01/2003
1Endometriosis (Adenomyosis)
03/2011
1Leiomyoma (Uterine Fibroids)
03/2011
1Hyperplasia
01/2010
1Carcinoma in Situ
01/2005
1Multiple Myeloma
02/2004
1Lymphoma (Lymphomas)
02/2004
1Hematologic Neoplasms (Hematological Malignancy)
02/2004
1Leukemia
02/2004
1Prostatic Neoplasms (Prostate Cancer)
01/2003

Drug/Important Bio-Agent (IBA)

10RetinoidsIBA
07/2015 - 10/2004
6Methylnitrosourea (N-Methyl-N-nitrosourea)IBA
04/2008 - 02/2003
5Retinoid X Receptors (Retinoid X Receptor)IBA
01/2014 - 10/2004
4Estrogens (Estrogen)FDA Link
04/2013 - 02/2003
4bexarotene (LGD1069)FDA Link
04/2013 - 02/2005
4AzurinIBA
09/2011 - 03/2004
3cupredoxinIBA
09/2011 - 03/2004
3Amino AcidsFDA Link
09/2011 - 01/2009
3ProgesteroneFDA LinkGeneric
03/2011 - 07/2003
3Biological Markers (Surrogate Marker)IBA
04/2008 - 02/2003
2Retinoic Acid Receptors (Retinoic Acid Receptor)IBA
07/2015 - 05/2005
2AntibodiesIBA
04/2013 - 09/2011
2FenretinideIBA
09/2011 - 05/2005
2Protein Isoforms (Isoforms)IBA
09/2011 - 03/2009
2CDB 4124IBA
03/2011 - 07/2007
2retinoic acid receptor betaIBA
03/2009 - 10/2004
2CopperIBA
01/2009 - 03/2004
2HormonesIBA
10/2007 - 07/2007
2Tretinoin (Retinoic Acid)FDA LinkGeneric
12/2004 - 10/2004
1UAB 30IBA
01/2014
1Antineoplastic Agents (Antineoplastics)IBA
04/2013
1Doxorubicin (Adriamycin)FDA LinkGeneric
01/2013
1Phosphotransferases (Kinase)IBA
01/2013
1Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
09/2011
1Messenger RNA (mRNA)IBA
09/2011
1Cyclin-Dependent Kinases (cdk Proteins)IBA
05/2011
1Progesterone Receptors (Progesterone Receptor)IBA
03/2011
1Proteins (Proteins, Gene)IBA
01/2009
1PeptidesIBA
01/2009
1GlycosaminoglycansIBA
01/2009
1Cell-Penetrating PeptidesIBA
01/2009
1gefitinib (Iressa)FDA Link
04/2008
1Epidermal Growth Factor Receptor (EGF Receptor)IBA
04/2008
1Dihydrotachysterol (AT 10)IBA
04/2008
1vorozoleIBA
04/2008
1IGF Type 1 Receptor (IGF 1 Receptor)IBA
10/2007
1Growth Hormone (Somatotropin)IBA
10/2007
1Insulin-Like Growth Factor I (IGF-1)IBA
10/2007
1Tyrosine (L-Tyrosine)FDA Link
07/2007
19,10-Dimethyl-1,2-benzanthracene (DMBA)IBA
07/2007
1Mifepristone (RU 486)FDA Link
07/2007
1anthraceneIBA
07/2007
1Progestins (Progestagens)IBA
07/2007
1alitretinoinFDA Link
06/2006
1tipifarnib (R115777)IBA
04/2006
1TransferasesIBA
04/2006
1Dehydroepiandrosterone (DHEA)IBA
01/2005
1retinoic acid receptor alphaIBA
10/2004
1bruceantinIBA
02/2004
1DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
02/2004
1Estradiol (Estrace)FDA LinkGeneric
07/2003
1Estrogen Receptor alphaIBA
07/2003
1Selective Estrogen Receptor Modulators (SERM)IBA
02/2003
1TamoxifenFDA LinkGeneric
02/2003
1Cyclin D1IBA
02/2003
1Cyclin EIBA
02/2003
1lycopeneIBA
01/2003
1Prostate-Specific Antigen (Semenogelase)IBA
01/2003
1Cyclin DIBA
11/2002

Therapy/Procedure

2Heterologous Transplantation (Xenotransplantation)
09/2011 - 02/2004
1Therapeutics
10/2007
1Chemoprevention
07/2007
1Prostatectomy (Retropubic Prostatectomy)
01/2003