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Ann-Lii Cheng Selected Research

sorafenib (BAY 43-9006)

10/2015Safety and efficacy of tigatuzumab plus sorafenib as first-line therapy in subjects with advanced hepatocellular carcinoma: A phase 2 randomized study.
9/2015Predictive biomarkers of sorafenib efficacy in advanced hepatocellular carcinoma: Are we getting there?
8/2015High Serum Transforming Growth Factor-β1 Levels Predict Outcome in Hepatocellular Carcinoma Patients Treated with Sorafenib.
1/2015Treatment efficacy differences of sorafenib for advanced hepatocellular carcinoma: a meta-analysis of randomized clinical trials.
12/2014Potential synergistic anti-tumor activity between lenalidomide and sorafenib in hepatocellular carcinoma.
2/2014Clinical characteristics of advanced hepatocellular carcinoma patients with prolonged survival in the era of anti-angiogenic targeted-therapy.
1/2014Sorafenib relieves cell-intrinsic and cell-extrinsic inhibitions of effector T cells in tumor microenvironment to augment antitumor immunity.
11/2013Sunitinib versus sorafenib in advanced hepatocellular cancer: results of a randomized phase III trial.
10/2013Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized phase III BRISK-FL study.
8/2013Clinical trials in hepatocellular carcinoma: an update.
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Ann-Lii Cheng Research Topics

Disease

100Neoplasms (Cancer)
10/2015 - 01/2002
64Hepatocellular Carcinoma (Hepatoma)
10/2015 - 01/2003
19Carcinoma (Carcinomatosis)
04/2013 - 04/2002
18Breast Neoplasms (Breast Cancer)
04/2015 - 08/2005
15Lymphoma (Lymphomas)
11/2015 - 06/2003
14Neoplasm Metastasis (Metastasis)
04/2015 - 11/2002
10Colorectal Neoplasms (Colorectal Cancer)
07/2015 - 02/2002
10Infection
06/2014 - 11/2002
10Marginal Zone B-Cell Lymphoma (MALT Lymphoma)
02/2014 - 07/2005
7Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell)
02/2014 - 09/2005
7Stomach Neoplasms (Stomach Cancer)
01/2014 - 03/2004
7Pancreatic Neoplasms (Pancreatic Cancer)
05/2013 - 03/2006
7Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
06/2009 - 01/2005
6Squamous Cell Carcinoma (Epidermoid Carcinoma)
03/2015 - 07/2007
6Adenocarcinoma
07/2014 - 04/2004
6Hepatitis B
06/2014 - 03/2008
5Colonic Neoplasms (Colon Cancer)
09/2014 - 04/2004
5Lung Neoplasms (Lung Cancer)
12/2013 - 05/2008
4B-Cell Lymphoma (Lymphoma, B Cell)
09/2015 - 10/2007
4Non-Hodgkin Lymphoma (Lymphosarcoma)
09/2015 - 03/2008
4Hepatitis
06/2014 - 06/2003
4Liver Neoplasms (Liver Cancer)
02/2014 - 01/2011
4Disease Progression
10/2013 - 09/2005
3Urinary Bladder Neoplasms (Bladder Cancer)
03/2015 - 10/2009
3Prostatic Neoplasms (Prostate Cancer)
01/2015 - 07/2004
3Fatigue
10/2013 - 01/2009
3Hypersensitivity (Allergy)
05/2010 - 11/2002
3Hepatoblastoma
12/2009 - 09/2004
2Glioblastoma (Glioblastoma Multiforme)
11/2014 - 01/2013
2Chronic Hepatitis B
02/2014 - 01/2012
2Thrombocytopenia (Thrombopenia)
11/2013 - 05/2006

Drug/Important Bio-Agent (IBA)

29sorafenib (BAY 43-9006)FDA Link
10/2015 - 01/2009
24Fluorouracil (Carac)FDA LinkGeneric
09/2014 - 02/2002
21Cisplatin (Platino)FDA LinkGeneric
10/2015 - 04/2002
19Leucovorin (Folinic Acid)FDA Link
01/2014 - 02/2002
12Paclitaxel (Taxol)FDA LinkGeneric
10/2015 - 11/2002
12Phosphotransferases (Kinase)IBA
03/2015 - 04/2004
12gemcitabineFDA Link
05/2013 - 08/2005
10Doxorubicin (Adriamycin)FDA LinkGeneric
06/2014 - 07/2003
9oxaliplatin (Eloxatin)FDA LinkGeneric
01/2014 - 04/2004
8Biological Markers (Surrogate Marker)IBA
09/2015 - 10/2007
8NF-kappa B (NF-kB)IBA
07/2012 - 04/2002
7DNA (Deoxyribonucleic Acid)IBA
06/2014 - 01/2006
7bortezomib (Velcade)FDA Link
01/2013 - 08/2008
6Epidermal Growth Factor Receptor (EGF Receptor)IBA
07/2015 - 08/2005
5Proteins (Proteins, Gene)IBA
06/2015 - 02/2009
5bevacizumabFDA Link
04/2015 - 05/2009
5Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
01/2015 - 04/2009
5Estrogens (Estrogen)FDA Link
06/2014 - 12/2008
5alpha-Fetoproteins (AFP)IBA
02/2014 - 06/2009
4Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
03/2015 - 09/2008
4Sirolimus (Rapamycin)FDA Link
02/2015 - 12/2010
4TamoxifenFDA LinkGeneric
11/2014 - 11/2003
4TegafurIBA
09/2014 - 07/2010
4Insulin (Novolin)FDA Link
09/2014 - 07/2012
4aurora kinase (aurora A kinase)IBA
07/2014 - 02/2009
4rituximab (Mabthera)FDA Link
06/2014 - 02/2012
4sunitinib (Sutent)FDA Link
11/2013 - 01/2011
4Methotrexate (Mexate)FDA LinkGeneric
09/2013 - 11/2002
4HormonesIBA
01/2013 - 05/2007
4Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2012 - 07/2004
4Thalidomide (Thalomid)FDA Link
01/2012 - 01/2003
37-hydroxy-6-methoxyphthalide (MA-1)IBA
09/2015 - 11/2011
3erlotinib (CP 358,774)FDA Link
03/2015 - 01/2013
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2015 - 08/2010
3UracilIBA
09/2014 - 07/2010
3VX680IBA
07/2014 - 03/2009
3Progesterone Receptors (Progesterone Receptor)IBA
06/2014 - 12/2008
3Hepatitis B Surface Antigens (HBsAg)FDA Link
06/2014 - 06/2003
3everolimusFDA Link
01/2014 - 12/2010
3Adenocarcinoma of lungIBA
12/2013 - 08/2005
3thymidine 5'-triphosphate (TTP)IBA
10/2013 - 01/2011
3Protein Phosphatase 2 (Protein Phosphatase 2A)IBA
02/2013 - 04/2012
3Carbon MonoxideIBA
01/2013 - 07/2005
3Proteasome Endopeptidase Complex (Proteasome)IBA
01/2013 - 08/2008
3Dacarbazine (DIC)FDA LinkGeneric
07/2010 - 11/2003
3gefitinib (Iressa)FDA Link
06/2009 - 08/2005
3arsenic trioxide (Trisenox)FDA Link
11/2008 - 02/2005
3Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
09/2006 - 10/2005
3GlucocorticoidsIBA
09/2006 - 10/2005
3Nasopharyngeal carcinomaIBA
05/2006 - 01/2002
2tigatuzumabIBA
10/2015 - 03/2012
2Codon (Codons)IBA
07/2015 - 08/2005
2Monoclonal AntibodiesIBA
07/2015 - 09/2014
2cetuximab (Erbitux)FDA Link
07/2015 - 09/2014
2CytotoxinsIBA
04/2015 - 01/2015
2Etoposide (VP 16)FDA LinkGeneric
04/2015 - 01/2015
2Small Interfering RNA (siRNA)IBA
03/2015 - 08/2012
2MK 2206IBA
01/2015 - 01/2014
2temozolomide (Temodar)FDA LinkGeneric
11/2014 - 06/2010
2Alanine Transaminase (SGPT)IBA
06/2014 - 07/2012
2AnthracyclinesIBA
12/2013 - 01/2005
2Reactive Oxygen Species (Oxygen Radicals)IBA
12/2013 - 11/2008

Therapy/Procedure

60Drug Therapy (Chemotherapy)
03/2015 - 01/2002
17Heterologous Transplantation (Xenotransplantation)
07/2014 - 10/2007
12Radiotherapy
08/2015 - 12/2008
6Combination Drug Therapy (Combination Chemotherapy)
09/2013 - 11/2002
4Surgical Instruments (Clip)
02/2014 - 06/2009
3Molecular Targeted Therapy
12/2014 - 08/2010
2Combined Modality Therapy
07/2014 - 06/2012