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Xiaoyan Chen Selected Research

3-n-butylphthalide (butylphthalide)

4/2014Bioactivation of 3-n-butylphthalide via sulfation of its major metabolite 3-hydroxy-NBP: mediated mainly by sulfotransferase 1A1.
5/2013Simultaneous quantitation of 3-n-butylphthalide (NBP) and its four major metabolites in human plasma by LC-MS/MS using deuterated internal standards.
2/2013Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation.

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Xiaoyan Chen Research Topics

Disease

15Neoplasms (Cancer)
01/2015 - 11/2008
7Stroke (Strokes)
12/2014 - 01/2008
5Infection
12/2015 - 05/2005
5Cardiovascular Diseases (Cardiovascular Disease)
01/2015 - 01/2006
4Brain Ischemia (Cerebral Ischemia)
12/2015 - 02/2013
4Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
12/2014 - 01/2014
3Breast Neoplasms (Breast Cancer)
04/2015 - 08/2012
3Pain (Aches)
01/2015 - 11/2013
3Inflammation
01/2014 - 11/2008
3Lung Injury
06/2012 - 03/2010
3Myopia
01/2012 - 01/2010
2Ischemia
10/2015 - 01/2014
2Osteoarthritis
01/2015 - 01/2014
2Knee Injuries (Knee Injury)
01/2015 - 01/2014
2Anaphylaxis (Anaphylactic Shock)
11/2014 - 08/2012
2Bacterial Infections (Bacterial Infection)
10/2014 - 06/2014
2Amebiasis (Amoebiasis)
10/2014 - 06/2014
2Aneurysm (Aneurysms)
01/2014 - 10/2005
2Pancreatitis
11/2012 - 05/2012
2BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
05/2012 - 08/2010
2Hemorrhage
12/2011 - 03/2010
1Hyperbilirubinemia
11/2015
1Type 2 Diabetes Mellitus (MODY)
11/2015
1Blindness (Hysterical Blindness)
10/2015
1Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma)
08/2015
1Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral)
08/2015
1Hyperplasia
08/2015
1Disease Progression
07/2015
1Hepatocellular Carcinoma (Hepatoma)
07/2015
1Dysmenorrhea (Menstrual Pain)
04/2015
1Stomach Neoplasms (Stomach Cancer)
01/2015
1Cataract (Cataracts)
01/2015
1Carotid Stenosis (Carotid Artery Stenosis)
01/2015
1Carotid Artery Diseases
01/2015
1Neoplasm Metastasis (Metastasis)
01/2015
1Coronary Disease (Coronary Heart Disease)
01/2015
1Atherosclerosis
01/2015
1Migraine Disorders (Migraine)
12/2014
1Brain Edema (Cerebral Edema)
12/2014
1Essential Tremor (Essential Tremors)
12/2014
1Atrophy
10/2014
1Multiple Myeloma
09/2014
1Flushing
06/2014
1Coronary Artery Disease (Coronary Atherosclerosis)
05/2014

Drug/Important Bio-Agent (IBA)

7MicroRNAs (MicroRNA)IBA
08/2015 - 04/2009
4Uveal melanomaIBA
03/2013 - 04/2009
3salicylhydroxamic acid (SHAM)IBA
04/2015 - 01/2014
3CytokinesIBA
12/2014 - 06/2005
3morinidazoleIBA
10/2014 - 11/2012
33-n-butylphthalide (butylphthalide)IBA
04/2014 - 02/2013
3Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
11/2013 - 08/2010
2Protein Kinases (Protein Kinase)IBA
12/2015 - 05/2015
2BilirubinIBA
11/2015 - 11/2013
2Glucose (Dextrose)FDA LinkGeneric
04/2015 - 01/2015
2Small Interfering RNA (siRNA)IBA
12/2014 - 04/2013
2erucylphosphocholineIBA
10/2014 - 01/2014
2Interleukin-8 (Interleukin 8)IBA
10/2014 - 10/2009
24-nitroimidazoleIBA
10/2014 - 06/2014
2TabletsIBA
12/2013 - 08/2010
2Tyrosine (L-Tyrosine)FDA Link
11/2013 - 01/2011
2tyrosine receptor (receptor, tyrosine)IBA
04/2013 - 11/2008
2Phosphotransferases (Kinase)IBA
04/2013 - 11/2008
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
11/2012 - 10/2009
2Interleukin-6 (Interleukin 6)IBA
11/2012 - 10/2009
2dauricineIBA
06/2012 - 03/2010
2CollagenIBA
01/2012 - 01/2011
2Ketoconazole (Nizoral)FDA LinkGeneric
12/2011 - 03/2010
2scutellarinIBA
11/2011 - 08/2006
2DNA (Deoxyribonucleic Acid)IBA
01/2011 - 01/2010
1Aquaporin 4IBA
12/2015
1GTP-Binding Proteins (G-Protein)IBA
11/2015
1Retinaldehyde (Retinal)IBA
10/2015
1Estrogens (Estrogen)FDA Link
07/2015
1Adenosine Triphosphate (ATP)IBA
04/2015
1HexokinaseIBA
04/2015
1arginyl- threonyl- prolyl- prolyl- prolyl- seryl- glycine (SP 6)IBA
04/2015
1fibroblast growth factor 21IBA
01/2015
117-hydroxyestrane-3-carbonitrile (ECN)IBA
01/2015
1OxygenIBA
01/2015
1EnzymesIBA
01/2015
1PlacebosIBA
01/2015
1Dopamine Receptors (Dopamine Receptor)IBA
12/2014
1Histamine (Histamine Dihydrochloride)FDA Link
11/2014
1HMGB1 Protein (HMG1)IBA
10/2014
1Complementary DNA (cDNA)IBA
09/2014
1triphosphoric acid (triphosphate)IBA
08/2014
1clofarabine (Clolar)FDA Link
08/2014
1ethyl acetateIBA
06/2014
1methyl carbonate (dimethyl carbonate)IBA
06/2014
1Gasoline (Diesel Fuel)IBA
06/2014
1butyl acetateIBA
06/2014
1octaneIBA
06/2014
1CytochromesIBA
05/2014
1Heme Oxygenase-1IBA
05/2014
1Epoxide HydrolasesIBA
05/2014

Therapy/Procedure

3Transplantation (Transplant Recipients)
12/2014 - 01/2014
3Oral Administration
12/2013 - 08/2010
2Complementary Therapies (Alternative Medicine)
04/2011 - 01/2008
1Acupuncture Analgesia
04/2015
1Aftercare (After-Treatment)
01/2015