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Irshad H Chaudry Selected Research

Estrogens (Estrogen)

10/2008Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels.
08/2008Estrogen ameliorates trauma-hemorrhage-induced lung injury via endothelial nitric oxide synthase-dependent activation of protein kinase G.
07/2008The role of estrogen receptor subtypes on hepatic neutrophil accumulation following trauma-hemorrhage: Direct modulation of CINC-1 production by Kupffer cells.
06/2008Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1.
04/2008Mitogen activated protein kinase (MAPK) mediates non-genomic pathway of estrogen on T cell cytokine production following trauma-hemorrhage.
03/2008Estrogen-mediated activation of non-genomic pathway improves macrophages cytokine production following trauma-hemorrhage.
03/2008Estrogen: a novel therapeutic adjunct for the treatment of trauma-hemorrhage-induced immunological alterations.
10/2007Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulation.
09/2007Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of the PI-3K/Akt pathway.
06/2007Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage.
06/2007The role of estrogen receptor subtypes in ameliorating hepatic injury following trauma-hemorrhage.
06/2007The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhage.
05/2007Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage.
05/2007Downregulation of TLR4-dependent ATP production is critical for estrogen-mediated immunoprotection in Kupffer cells following trauma-hemorrhage.
04/2007G protein-coupled receptor 30-dependent protein kinase A pathway is critical in nongenomic effects of estrogen in attenuating liver injury after trauma-hemorrhage.
02/2007Flutamide attenuates pro-inflammatory cytokine production and hepatic injury following trauma-hemorrhage via estrogen receptor-related pathway.
01/2007Tissue compartment-specific role of estrogen receptor subtypes in immune cell cytokine production following trauma-hemorrhage.
06/2006Are the protective effects of 17beta-estradiol on splenic macrophages and splenocytes after trauma-hemorrhage mediated via estrogen-receptor (ER)-alpha or ER-beta?
01/2006Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1.
12/2005PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage.
05/2002Estrogen pretreatment protects males against hypoxia-induced immune depression.

Articles by Research Topic

Disease

87Wounds and Injuries (Trauma)
10/2008 - 01/2002
78Hemorrhage
10/2008 - 01/2002
13Sepsis (Septicemia)
07/2008 - 01/2002
6Burns
05/2008 - 02/2005
6Hemorrhagic Shock
01/2006 - 06/2003
4Poisoning
05/2008 - 08/2006
2Bone Fractures (Bone Fracture)
01/2007 - 01/2007
2Anoxia (Hypoxia)
09/2006 - 05/2002
2Shock
01/2006 - 01/2004
1Multiple Organ Failure (MODS)
02/2007
1Multiple Trauma (Multiple Injuries)
02/2007
1Edema
05/2005
1Insulin Resistance
11/2004
1Brain Death (Brain Dead)
12/2003

Drug/Important Bio-Agent (IBA)

21Estrogens (Estrogen)FDA Link
10/2008 - 05/2002
10Estradiol (Estrace)FDA LinkGeneric
06/2008 - 01/2002
8Flutamide (Eulexin)FDA LinkGeneric
08/2008 - 07/2005
7AndrostenediolIBA
03/2007 - 08/2004
5p38 Mitogen-Activated Protein KinasesIBA
06/2008 - 07/2003
5Interleukin-6 (Interleukin 6)IBA
03/2007 - 08/2004
5Estrogen Receptor betaIBA
09/2006 - 01/2006
4Estrogen Receptor alphaIBA
01/2008 - 08/2006
4Gonadal Steroid Hormones (Sex Hormones)IBA
09/2007 - 01/2002
4Peroxidase (Myeloperoxidase)IBA
09/2007 - 05/2005
4Estrogen ReceptorsIBA
05/2006 - 03/2003
3SteroidsIBA
07/2008 - 01/2004
3Protein Kinases (Protein Kinase)IBA
04/2008 - 06/2007
3Endothelin-1 (Endothelin 1)IBA
01/2007 - 09/2004
3CorticosteroneIBA
12/2006 - 07/2005
3AdrenomedullinIBA
11/2002 - 04/2002
2Heme Oxygenase-1IBA
05/2008 - 09/2006
2Adenosine Triphosphate (ATP)IBA
05/2007 - 01/2004
2Toll-Like Receptors (Toll-Like Receptor)IBA
03/2007 - 10/2005
2Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
03/2007 - 02/2005
2Interleukin-18 (Interleukin 18)IBA
08/2006 - 05/2005
2Heat-Shock Proteins (Heat-Shock Protein)IBA
03/2006 - 01/2006
2Dehydroepiandrosterone (DHEA)IBA
10/2005 - 08/2003
2Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA
07/2005 - 12/2003
2Interleukin-10 (Interleukin 10)IBA
06/2004 - 05/2004
2Prolactin Receptors (Prolactin Receptor)IBA
12/2003 - 05/2002
2ProgesteroneFDA LinkGeneric
07/2003 - 06/2003
1GlycogenIBA
10/2008
1Chemokine CCL3IBA
08/2008
1Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
08/2008
1Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA
08/2008
1neutrophil cytosol factor 67KIBA
05/2008
1Protein Tyrosine PhosphatasesIBA
05/2008
1HormonesIBA
03/2008
1Mitogen-Activated Protein KinasesIBA
07/2007
1N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime (PUGNAC)IBA
04/2007
1GTP-Binding Proteins (G-Protein)IBA
04/2007
1Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
04/2007
1Caspase 3 (Caspase-3)IBA
03/2007
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
03/2007
1Interleukin-6 Receptors (Interleukin 6 Receptor)IBA
03/2007
1CytokinesIBA
02/2007
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
01/2007
1Keratins (Keratin)IBA
01/2007
1Lidocaine (Xylocaine)FDA LinkGeneric
11/2006
1src-Family KinasesIBA
09/2006
1PPAR gammaIBA
07/2006
1Peroxisome ProliferatorsIBA
08/2005
1ProlactinIBA
05/2005
1OxygenIBA
02/2005
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
11/2004
1Dihydrotestosterone (Androstanolone)IBA
02/2004
1Testosterone (Sustanon)FDA LinkGeneric
07/2003
1NF-kappa B (NF-kB)IBA
10/2002
1adrenomedullin receptorIBA
04/2002
1Arginine (L-Arginine)FDA Link
01/2002

Therapy/Procedure

4Resuscitation
10/2008 - 03/2002
1Transplantation (Transplant Recipients)
12/2003